New Developments in Exosomal lncRNAs in Cardiovascular Diseases
Long non-coding RNAs (lncRNAs) are non-coding RNAs with lengths >200 nt and are involved in the occurrence and development of cardiovascular diseases (CVDs). Exosomes are secreted and produced by various cell types. Exosome contents include various ncRNAs, proteins and lipids. Exosomes are al...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.709169/full |
| _version_ | 1819204231943421952 |
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| author | Zhu Yuan Weiqiang Huang |
| author_facet | Zhu Yuan Weiqiang Huang |
| author_sort | Zhu Yuan |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) are non-coding RNAs with lengths >200 nt and are involved in the occurrence and development of cardiovascular diseases (CVDs). Exosomes are secreted and produced by various cell types. Exosome contents include various ncRNAs, proteins and lipids. Exosomes are also important mediators of intercellular communication. The proportion of lncRNAs in exosomes is low, but increasing evidence suggests that exosomal lncRNAs play important roles in CVDs. We focused on research progress in exosomal lncRNAs in atherosclerosis, myocardial infarction, myocardial ischemia-reperfusion injury, cardiac angiogenesis, cardiac aging, rheumatic heart disease, and chronic kidney disease combined with CVD. The potential diagnostic and therapeutic effects of exosomal lncRNAs in CVDs are summarized based on preclinical studies involving animal and cell models and circulating exosomes in clinical patients. Finally, the challenges and possible prospects of exosomes and exosomal lncRNAs in clinical applications related to CVD are discussed. |
| first_indexed | 2024-12-23T04:32:32Z |
| format | Article |
| id | doaj.art-5aa6d2ff37d345e9951fb81d926e2698 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-23T04:32:32Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-5aa6d2ff37d345e9951fb81d926e26982022-12-21T17:59:58ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-07-01810.3389/fcvm.2021.709169709169New Developments in Exosomal lncRNAs in Cardiovascular DiseasesZhu YuanWeiqiang HuangLong non-coding RNAs (lncRNAs) are non-coding RNAs with lengths >200 nt and are involved in the occurrence and development of cardiovascular diseases (CVDs). Exosomes are secreted and produced by various cell types. Exosome contents include various ncRNAs, proteins and lipids. Exosomes are also important mediators of intercellular communication. The proportion of lncRNAs in exosomes is low, but increasing evidence suggests that exosomal lncRNAs play important roles in CVDs. We focused on research progress in exosomal lncRNAs in atherosclerosis, myocardial infarction, myocardial ischemia-reperfusion injury, cardiac angiogenesis, cardiac aging, rheumatic heart disease, and chronic kidney disease combined with CVD. The potential diagnostic and therapeutic effects of exosomal lncRNAs in CVDs are summarized based on preclinical studies involving animal and cell models and circulating exosomes in clinical patients. Finally, the challenges and possible prospects of exosomes and exosomal lncRNAs in clinical applications related to CVD are discussed.https://www.frontiersin.org/articles/10.3389/fcvm.2021.709169/fullexosomal lncRNAcardiovascular diseaseatherosclerosismyocardial infarctioncardiac angiogenesis |
| spellingShingle | Zhu Yuan Weiqiang Huang New Developments in Exosomal lncRNAs in Cardiovascular Diseases Frontiers in Cardiovascular Medicine exosomal lncRNA cardiovascular disease atherosclerosis myocardial infarction cardiac angiogenesis |
| title | New Developments in Exosomal lncRNAs in Cardiovascular Diseases |
| title_full | New Developments in Exosomal lncRNAs in Cardiovascular Diseases |
| title_fullStr | New Developments in Exosomal lncRNAs in Cardiovascular Diseases |
| title_full_unstemmed | New Developments in Exosomal lncRNAs in Cardiovascular Diseases |
| title_short | New Developments in Exosomal lncRNAs in Cardiovascular Diseases |
| title_sort | new developments in exosomal lncrnas in cardiovascular diseases |
| topic | exosomal lncRNA cardiovascular disease atherosclerosis myocardial infarction cardiac angiogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.709169/full |
| work_keys_str_mv | AT zhuyuan newdevelopmentsinexosomallncrnasincardiovasculardiseases AT weiqianghuang newdevelopmentsinexosomallncrnasincardiovasculardiseases |