Effect of soy isoflavone supplementation on blood pressure: a meta-analysis of randomized controlled trials
Abstract Background Previous experimental studies have suggested that the consumption of soy isoflavones may have a potential impact on lowering blood pressure. Nevertheless, epidemiological studies have presented conflicting outcomes concerning the correlation between soy isoflavone consumption and...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-024-00932-6 |
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| author | Lifu Lei Suocheng Hui Yushi Chen Hongjia Yan Jian Yang Shiwen Tong |
| author_facet | Lifu Lei Suocheng Hui Yushi Chen Hongjia Yan Jian Yang Shiwen Tong |
| author_sort | Lifu Lei |
| collection | DOAJ |
| description | Abstract Background Previous experimental studies have suggested that the consumption of soy isoflavones may have a potential impact on lowering blood pressure. Nevertheless, epidemiological studies have presented conflicting outcomes concerning the correlation between soy isoflavone consumption and blood pressure levels. Consequently, a comprehensive meta-analysis of all eligible randomized controlled trials (RCTs) was conducted to explore the influence of soy isoflavones on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in adults. Methods A thorough search of PubMed, Embase, and the Cochrane Library for relevant literature up to April 30, 2023 was conducted. RCTs involving adults that compared soy isoflavone supplementation with a placebo (the same matrix devoid of soy isoflavone) were included. The combined effect size was presented as the weighted mean difference (WMD) along with 95% confidence interval (CI), employing a fixed-effects model. Results Our meta-analysis included a total of 24 studies involving 1945 participants. The results revealed a significant reduction in both SBP and DBP with soy isoflavone supplementation. Subgroup analyses suggested more pronounced reductions in SBP and DBP for interventions lasting ≥6 months, in individuals receiving mixed-type soy isoflavone, and among patients with metabolic syndrome or prehypertension. However, we did not detect significant nonlinear associations between supplementation dosage and intervention duration concerning both SBP and DBP. The overall quality of evidence was deemed moderate. Conclusions The current meta-analysis revealed that supplementation with soy isoflavones alone effectively reduces blood pressure. Additional high-quality studies are required to investigate the efficacy of blood pressure reduction through supplementation with an optimal quantity and proportion of soy isoflavone. |
| first_indexed | 2024-04-25T01:08:05Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-04-25T01:08:05Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-5aa7e3395d21409692d5fde28b7a7b4a2024-03-10T12:06:27ZengBMCNutrition Journal1475-28912024-03-0123111210.1186/s12937-024-00932-6Effect of soy isoflavone supplementation on blood pressure: a meta-analysis of randomized controlled trialsLifu Lei0Suocheng Hui1Yushi Chen2Hongjia Yan3Jian Yang4Shiwen Tong5Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Clinical Nutrition, The People’s Hospital of Chongqing Liang Jiang New AreaDepartment of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Clinical Nutrition, The People’s Hospital of Chongqing Liang Jiang New AreaDepartment of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical UniversityDepartment of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical UniversityAbstract Background Previous experimental studies have suggested that the consumption of soy isoflavones may have a potential impact on lowering blood pressure. Nevertheless, epidemiological studies have presented conflicting outcomes concerning the correlation between soy isoflavone consumption and blood pressure levels. Consequently, a comprehensive meta-analysis of all eligible randomized controlled trials (RCTs) was conducted to explore the influence of soy isoflavones on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in adults. Methods A thorough search of PubMed, Embase, and the Cochrane Library for relevant literature up to April 30, 2023 was conducted. RCTs involving adults that compared soy isoflavone supplementation with a placebo (the same matrix devoid of soy isoflavone) were included. The combined effect size was presented as the weighted mean difference (WMD) along with 95% confidence interval (CI), employing a fixed-effects model. Results Our meta-analysis included a total of 24 studies involving 1945 participants. The results revealed a significant reduction in both SBP and DBP with soy isoflavone supplementation. Subgroup analyses suggested more pronounced reductions in SBP and DBP for interventions lasting ≥6 months, in individuals receiving mixed-type soy isoflavone, and among patients with metabolic syndrome or prehypertension. However, we did not detect significant nonlinear associations between supplementation dosage and intervention duration concerning both SBP and DBP. The overall quality of evidence was deemed moderate. Conclusions The current meta-analysis revealed that supplementation with soy isoflavones alone effectively reduces blood pressure. Additional high-quality studies are required to investigate the efficacy of blood pressure reduction through supplementation with an optimal quantity and proportion of soy isoflavone.https://doi.org/10.1186/s12937-024-00932-6Soy isoflavoneSystolic blood pressureDiastolic blood pressureHypertensionDose-response |
| spellingShingle | Lifu Lei Suocheng Hui Yushi Chen Hongjia Yan Jian Yang Shiwen Tong Effect of soy isoflavone supplementation on blood pressure: a meta-analysis of randomized controlled trials Nutrition Journal Soy isoflavone Systolic blood pressure Diastolic blood pressure Hypertension Dose-response |
| title | Effect of soy isoflavone supplementation on blood pressure: a meta-analysis of randomized controlled trials |
| title_full | Effect of soy isoflavone supplementation on blood pressure: a meta-analysis of randomized controlled trials |
| title_fullStr | Effect of soy isoflavone supplementation on blood pressure: a meta-analysis of randomized controlled trials |
| title_full_unstemmed | Effect of soy isoflavone supplementation on blood pressure: a meta-analysis of randomized controlled trials |
| title_short | Effect of soy isoflavone supplementation on blood pressure: a meta-analysis of randomized controlled trials |
| title_sort | effect of soy isoflavone supplementation on blood pressure a meta analysis of randomized controlled trials |
| topic | Soy isoflavone Systolic blood pressure Diastolic blood pressure Hypertension Dose-response |
| url | https://doi.org/10.1186/s12937-024-00932-6 |
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