Monitoring the elimination of human African trypanosomiasis: Update to 2016.
<h4>Background</h4>Human African trypanosomiasis (HAT) is a neglected tropical disease targeted for elimination 'as a public health problem' by 2020. The indicators to monitor progress towards the target are based on the number of reported cases, the related areas and populatio...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-12-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0006890 |
| _version_ | 1819281591288987648 |
|---|---|
| author | José R Franco Giuliano Cecchi Gerardo Priotto Massimo Paone Abdoulaye Diarra Lise Grout Pere P Simarro Weining Zhao Daniel Argaw |
| author_facet | José R Franco Giuliano Cecchi Gerardo Priotto Massimo Paone Abdoulaye Diarra Lise Grout Pere P Simarro Weining Zhao Daniel Argaw |
| author_sort | José R Franco |
| collection | DOAJ |
| description | <h4>Background</h4>Human African trypanosomiasis (HAT) is a neglected tropical disease targeted for elimination 'as a public health problem' by 2020. The indicators to monitor progress towards the target are based on the number of reported cases, the related areas and populations exposed at various levels of risk, and the coverage of surveillance activities. Based on data provided by the National Sleeping Sickness Control Programmes (NSSCP), Non-Governmental Organizations (NGOs) and research institutions-and assembled in the Atlas of HAT-the World Health Organization (WHO) provides here an update to 2016 for these indicators, as well as an analysis of the epidemiological situation.<h4>Results</h4>Trends for the two primary indicators of elimination are on track for the 2020 goal: 2,164 cases of HAT were reported in 2016 (as compared to the milestone of 4,000 cases), and for the period 2012-2016 280,000 km2 are estimated to be at moderate risk or higher (i.e. ≥ 1 case/10,000 people/year), as compared to the milestone of 230,000 km2. These figures correspond to reductions of 92% and 61% as compared to the respective baselines (i.e. 26,550 HAT cases in the year 2000, and 709,000 km2 exposed at various levels of risk for the period 2000-2004). Among the secondary indicators, an overall improvement in the coverage of at risk populations by surveillance activities was observed. Regarding passive surveillance, the number of fixed health facilities providing gambiense HAT diagnosis or treatment expanded, with 1,338 enumerated in endemic countries in 2017 (+52% as compared to the survey completed only sixteen months earlier). Concerning rhodesiense HAT, 124 health facilities currently provide diagnosis or treatment. The broadening of passive surveillance is occurring in a context of fairly stable intensity of active case finding, with between 1.8 million and 2.4 million people screened per year over the period 2012-2016.<h4>Discussion</h4>Elimination of HAT as a public health problem by 2020 seems within reach, as the epidemiological trends observed in previous years are confirmed in this latest 2016 monitoring update. However, looking beyond 2020, and in particular to the 2030 goal of elimination of transmission as zero cases for the gambiense form of the disease only, there is no room for complacency. Challenges still abound, including ensuring the effective integration of HAT control activities in the health system, sustaining the commitment of donors and HAT endemic countries, and clarifying the extent of the threat posed by cryptic reservoirs (e.g. human asymptomatic carriers and the possible animal reservoirs in gambiense HAT epidemiology). WHO provides through the network for HAT elimination the essential coordination of the wide range of stakeholders to ensure synergy of efforts. |
| first_indexed | 2024-12-24T01:02:07Z |
| format | Article |
| id | doaj.art-5aa8fb0741374da5b42383b54787fb37 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-24T01:02:07Z |
| publishDate | 2018-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-5aa8fb0741374da5b42383b54787fb372022-12-21T17:23:20ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352018-12-011212e000689010.1371/journal.pntd.0006890Monitoring the elimination of human African trypanosomiasis: Update to 2016.José R FrancoGiuliano CecchiGerardo PriottoMassimo PaoneAbdoulaye DiarraLise GroutPere P SimarroWeining ZhaoDaniel Argaw<h4>Background</h4>Human African trypanosomiasis (HAT) is a neglected tropical disease targeted for elimination 'as a public health problem' by 2020. The indicators to monitor progress towards the target are based on the number of reported cases, the related areas and populations exposed at various levels of risk, and the coverage of surveillance activities. Based on data provided by the National Sleeping Sickness Control Programmes (NSSCP), Non-Governmental Organizations (NGOs) and research institutions-and assembled in the Atlas of HAT-the World Health Organization (WHO) provides here an update to 2016 for these indicators, as well as an analysis of the epidemiological situation.<h4>Results</h4>Trends for the two primary indicators of elimination are on track for the 2020 goal: 2,164 cases of HAT were reported in 2016 (as compared to the milestone of 4,000 cases), and for the period 2012-2016 280,000 km2 are estimated to be at moderate risk or higher (i.e. ≥ 1 case/10,000 people/year), as compared to the milestone of 230,000 km2. These figures correspond to reductions of 92% and 61% as compared to the respective baselines (i.e. 26,550 HAT cases in the year 2000, and 709,000 km2 exposed at various levels of risk for the period 2000-2004). Among the secondary indicators, an overall improvement in the coverage of at risk populations by surveillance activities was observed. Regarding passive surveillance, the number of fixed health facilities providing gambiense HAT diagnosis or treatment expanded, with 1,338 enumerated in endemic countries in 2017 (+52% as compared to the survey completed only sixteen months earlier). Concerning rhodesiense HAT, 124 health facilities currently provide diagnosis or treatment. The broadening of passive surveillance is occurring in a context of fairly stable intensity of active case finding, with between 1.8 million and 2.4 million people screened per year over the period 2012-2016.<h4>Discussion</h4>Elimination of HAT as a public health problem by 2020 seems within reach, as the epidemiological trends observed in previous years are confirmed in this latest 2016 monitoring update. However, looking beyond 2020, and in particular to the 2030 goal of elimination of transmission as zero cases for the gambiense form of the disease only, there is no room for complacency. Challenges still abound, including ensuring the effective integration of HAT control activities in the health system, sustaining the commitment of donors and HAT endemic countries, and clarifying the extent of the threat posed by cryptic reservoirs (e.g. human asymptomatic carriers and the possible animal reservoirs in gambiense HAT epidemiology). WHO provides through the network for HAT elimination the essential coordination of the wide range of stakeholders to ensure synergy of efforts.https://doi.org/10.1371/journal.pntd.0006890 |
| spellingShingle | José R Franco Giuliano Cecchi Gerardo Priotto Massimo Paone Abdoulaye Diarra Lise Grout Pere P Simarro Weining Zhao Daniel Argaw Monitoring the elimination of human African trypanosomiasis: Update to 2016. PLoS Neglected Tropical Diseases |
| title | Monitoring the elimination of human African trypanosomiasis: Update to 2016. |
| title_full | Monitoring the elimination of human African trypanosomiasis: Update to 2016. |
| title_fullStr | Monitoring the elimination of human African trypanosomiasis: Update to 2016. |
| title_full_unstemmed | Monitoring the elimination of human African trypanosomiasis: Update to 2016. |
| title_short | Monitoring the elimination of human African trypanosomiasis: Update to 2016. |
| title_sort | monitoring the elimination of human african trypanosomiasis update to 2016 |
| url | https://doi.org/10.1371/journal.pntd.0006890 |
| work_keys_str_mv | AT joserfranco monitoringtheeliminationofhumanafricantrypanosomiasisupdateto2016 AT giulianocecchi monitoringtheeliminationofhumanafricantrypanosomiasisupdateto2016 AT gerardopriotto monitoringtheeliminationofhumanafricantrypanosomiasisupdateto2016 AT massimopaone monitoringtheeliminationofhumanafricantrypanosomiasisupdateto2016 AT abdoulayediarra monitoringtheeliminationofhumanafricantrypanosomiasisupdateto2016 AT lisegrout monitoringtheeliminationofhumanafricantrypanosomiasisupdateto2016 AT perepsimarro monitoringtheeliminationofhumanafricantrypanosomiasisupdateto2016 AT weiningzhao monitoringtheeliminationofhumanafricantrypanosomiasisupdateto2016 AT danielargaw monitoringtheeliminationofhumanafricantrypanosomiasisupdateto2016 |