Allelic polymorphisms of the BoLA-DRB3 gene and resistance to brucellosis in Kazakh cattle
The Authors investigated polymorphism of the bovine BoLA‑DRB3 gene in connection with resistance or susceptibility to brucellosis of two Kazakh meat breeds, Auliekol and Kazakh Whiteheaded breeds, using PCR‑RFLP. In Auliekol cattle (n = 158), 22 alleles were detected in the brucellosis group, and 2...
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| Format: | Article |
| Language: | English |
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Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale
2022-12-01
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| Series: | Veterinaria Italiana |
| Subjects: | |
| Online Access: | https://www.veterinariaitaliana.izs.it/index.php/VetIt/article/view/2528 |
| _version_ | 1827904820996997120 |
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| author | Akmaral Adambayeva Akhmetzhan A. Sultanov Irina Ya. Nam Vladimir V. Zayakin |
| author_facet | Akmaral Adambayeva Akhmetzhan A. Sultanov Irina Ya. Nam Vladimir V. Zayakin |
| author_sort | Akmaral Adambayeva |
| collection | DOAJ |
| description |
The Authors investigated polymorphism of the bovine BoLA‑DRB3 gene in connection with resistance or susceptibility to brucellosis of two Kazakh meat breeds, Auliekol and Kazakh Whiteheaded breeds, using PCR‑RFLP. In Auliekol cattle (n = 158), 22 alleles were detected in the brucellosis group, and 24 alleles were shown in the healthy group. BoLA-DRB3 alleles *3, *4, *19, *21 were more common in healthy animals, while Brucella‑positive cattle were more frequently carriers of alleles *7, *10, *18. In Kazakh Whiteheaded cattle (n = 146), 21 alleles were detected in infected and 23 alleles in healthy cattle. Alleles *3, *8, *21 significantly predominate in healthy cattle, while alleles *7, *11, *16 are typical for animals with brucellosis. This study identified BoLA-DRB3 alleles associated with genetic resistance (*3 and *21) and susceptibility (*7) to brucellosis; remarkably, resistance alleles are shared by two important meat breeds of Kazakhstan.
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| first_indexed | 2024-03-13T00:33:47Z |
| format | Article |
| id | doaj.art-5aaac2ffe9394df3ba57f2106940bdab |
| institution | Directory Open Access Journal |
| issn | 0505-401X 1828-1427 |
| language | English |
| last_indexed | 2024-03-13T00:33:47Z |
| publishDate | 2022-12-01 |
| publisher | Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale |
| record_format | Article |
| series | Veterinaria Italiana |
| spelling | doaj.art-5aaac2ffe9394df3ba57f2106940bdab2023-07-10T07:53:42ZengIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. CaporaleVeterinaria Italiana0505-401X1828-14272022-12-0158210.12834/VetIt.2528.15313.1Allelic polymorphisms of the BoLA-DRB3 gene and resistance to brucellosis in Kazakh cattleAkmaral Adambayeva0Akhmetzhan A. Sultanov1Irina Ya. Nam2Vladimir V. Zayakin3Kazakh Research Veterinary InstituteKazakh Research Veterinary InstituteNorth-West Institute of Management of RANEPA Bryansk State University named after acad. I.G. Petrovsky The Authors investigated polymorphism of the bovine BoLA‑DRB3 gene in connection with resistance or susceptibility to brucellosis of two Kazakh meat breeds, Auliekol and Kazakh Whiteheaded breeds, using PCR‑RFLP. In Auliekol cattle (n = 158), 22 alleles were detected in the brucellosis group, and 24 alleles were shown in the healthy group. BoLA-DRB3 alleles *3, *4, *19, *21 were more common in healthy animals, while Brucella‑positive cattle were more frequently carriers of alleles *7, *10, *18. In Kazakh Whiteheaded cattle (n = 146), 21 alleles were detected in infected and 23 alleles in healthy cattle. Alleles *3, *8, *21 significantly predominate in healthy cattle, while alleles *7, *11, *16 are typical for animals with brucellosis. This study identified BoLA-DRB3 alleles associated with genetic resistance (*3 and *21) and susceptibility (*7) to brucellosis; remarkably, resistance alleles are shared by two important meat breeds of Kazakhstan. https://www.veterinariaitaliana.izs.it/index.php/VetIt/article/view/2528BrucellosisBoLA-DRB3 geneallelic polymorphismgenetic resistance/susceptibilityPCR-RFLP |
| spellingShingle | Akmaral Adambayeva Akhmetzhan A. Sultanov Irina Ya. Nam Vladimir V. Zayakin Allelic polymorphisms of the BoLA-DRB3 gene and resistance to brucellosis in Kazakh cattle Veterinaria Italiana Brucellosis BoLA-DRB3 gene allelic polymorphism genetic resistance/susceptibility PCR-RFLP |
| title | Allelic polymorphisms of the BoLA-DRB3 gene and resistance to brucellosis in Kazakh cattle |
| title_full | Allelic polymorphisms of the BoLA-DRB3 gene and resistance to brucellosis in Kazakh cattle |
| title_fullStr | Allelic polymorphisms of the BoLA-DRB3 gene and resistance to brucellosis in Kazakh cattle |
| title_full_unstemmed | Allelic polymorphisms of the BoLA-DRB3 gene and resistance to brucellosis in Kazakh cattle |
| title_short | Allelic polymorphisms of the BoLA-DRB3 gene and resistance to brucellosis in Kazakh cattle |
| title_sort | allelic polymorphisms of the bola drb3 gene and resistance to brucellosis in kazakh cattle |
| topic | Brucellosis BoLA-DRB3 gene allelic polymorphism genetic resistance/susceptibility PCR-RFLP |
| url | https://www.veterinariaitaliana.izs.it/index.php/VetIt/article/view/2528 |
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