Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway
Abstract There is lack of knowledge about the safety of treatment with methadone and buprenorphine as part of opioid maintenance treatment (OMT) during pregnancy. The purpose of this study was to examine neonatal outcomes concerning the use of OMT during pregnancy. We used nationwide registry linkag...
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| Format: | Article |
| Language: | English |
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Wiley
2019-10-01
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| Series: | Pharmacology Research & Perspectives |
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| Online Access: | https://doi.org/10.1002/prp2.501 |
| _version_ | 1818865927551188992 |
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| author | Marte Handal Blanka Nechanská Svetlana Skurtveit Ingunn Olea Lund Roman Gabrhelík Anders Engeland Viktor Mravčík |
| author_facet | Marte Handal Blanka Nechanská Svetlana Skurtveit Ingunn Olea Lund Roman Gabrhelík Anders Engeland Viktor Mravčík |
| author_sort | Marte Handal |
| collection | DOAJ |
| description | Abstract There is lack of knowledge about the safety of treatment with methadone and buprenorphine as part of opioid maintenance treatment (OMT) during pregnancy. The purpose of this study was to examine neonatal outcomes concerning the use of OMT during pregnancy. We used nationwide registry linkages from the Czech Republic (2000‐2014) and Norway (2004‐2013). We compared prenatally OMT–exposed newborns with (a) newborns of women hospitalized with opioid use disorder during pregnancy in the Czech sample and (b) newborns with neonatal abstinence syndrome (NAS) in Norway. We performed multivariate linear and binary logistic regression exploring the associations between OMT and neonatal outcomes (growth parameters, gestational age, fetal death, small for gestational age, Apgar score, and NAS). Regression coefficients (b) and odds ratios (ORs) were estimated. The cohorts consisted of 333 Czech, and 235 Norwegian OMT–exposed newborns, and 106 and 294 newborns in the comparison groups, respectively. In both countries, the neonatal growth parameters were similar in the OMT and the comparison groups. In Norway, OMT exposure prolonged gestational age (adjusted b = 0.96 weeks, 95% confidence interval [CI] =0.39‐1.53) while the odds of preterm birth and Apgar score at 5 minutes were lower than in the comparison group (adjusted OR = 0.35, 0.16‐0.75 and aOR = 0.21, 0.06‐0.78, respectively). Newborns of women in OMT had similar growth parameters as newborns of women with opioid use disorders who were not in OMT during pregnancy. Overall, our findings do not suggest that OMT results in worse neonatal outcomes. |
| first_indexed | 2024-12-19T10:55:20Z |
| format | Article |
| id | doaj.art-5aaae5f5ce114785af061ffe6db292ca |
| institution | Directory Open Access Journal |
| issn | 2052-1707 |
| language | English |
| last_indexed | 2024-12-19T10:55:20Z |
| publishDate | 2019-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pharmacology Research & Perspectives |
| spelling | doaj.art-5aaae5f5ce114785af061ffe6db292ca2022-12-21T20:24:49ZengWileyPharmacology Research & Perspectives2052-17072019-10-0175n/an/a10.1002/prp2.501Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and NorwayMarte Handal0Blanka Nechanská1Svetlana Skurtveit2Ingunn Olea Lund3Roman Gabrhelík4Anders Engeland5Viktor Mravčík6Department of Mental Disorders Norwegian Institute of Public Health Oslo NorwayDepartment of Addictology, First Faculty of Medicine Charles University Prague Czech RepublicDepartment of Mental Disorders Norwegian Institute of Public Health Oslo NorwayDepartment of Mental Disorders Norwegian Institute of Public Health Oslo NorwayDepartment of Addictology, First Faculty of Medicine Charles University Prague Czech RepublicDepartment of Chronic Diseases and Ageing Norwegian Institute of Public Health Oslo NorwayDepartment of Addictology, First Faculty of Medicine Charles University Prague Czech RepublicAbstract There is lack of knowledge about the safety of treatment with methadone and buprenorphine as part of opioid maintenance treatment (OMT) during pregnancy. The purpose of this study was to examine neonatal outcomes concerning the use of OMT during pregnancy. We used nationwide registry linkages from the Czech Republic (2000‐2014) and Norway (2004‐2013). We compared prenatally OMT–exposed newborns with (a) newborns of women hospitalized with opioid use disorder during pregnancy in the Czech sample and (b) newborns with neonatal abstinence syndrome (NAS) in Norway. We performed multivariate linear and binary logistic regression exploring the associations between OMT and neonatal outcomes (growth parameters, gestational age, fetal death, small for gestational age, Apgar score, and NAS). Regression coefficients (b) and odds ratios (ORs) were estimated. The cohorts consisted of 333 Czech, and 235 Norwegian OMT–exposed newborns, and 106 and 294 newborns in the comparison groups, respectively. In both countries, the neonatal growth parameters were similar in the OMT and the comparison groups. In Norway, OMT exposure prolonged gestational age (adjusted b = 0.96 weeks, 95% confidence interval [CI] =0.39‐1.53) while the odds of preterm birth and Apgar score at 5 minutes were lower than in the comparison group (adjusted OR = 0.35, 0.16‐0.75 and aOR = 0.21, 0.06‐0.78, respectively). Newborns of women in OMT had similar growth parameters as newborns of women with opioid use disorders who were not in OMT during pregnancy. Overall, our findings do not suggest that OMT results in worse neonatal outcomes.https://doi.org/10.1002/prp2.501buprenorphinemethadoneneonateopioid maintenance treatmentprenatal exposure |
| spellingShingle | Marte Handal Blanka Nechanská Svetlana Skurtveit Ingunn Olea Lund Roman Gabrhelík Anders Engeland Viktor Mravčík Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway Pharmacology Research & Perspectives buprenorphine methadone neonate opioid maintenance treatment prenatal exposure |
| title | Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway |
| title_full | Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway |
| title_fullStr | Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway |
| title_full_unstemmed | Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway |
| title_short | Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway |
| title_sort | prenatal exposure to opioid maintenance treatment and neonatal outcomes nationwide registry studies from the czech republic and norway |
| topic | buprenorphine methadone neonate opioid maintenance treatment prenatal exposure |
| url | https://doi.org/10.1002/prp2.501 |
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