Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia

Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia

Emerging evidence links changes in the gut microbiome and intestinal barrier function to alterations in CNS function. We examined the role of endotoxin-responsive, cAMP-specific, Pde4 subfamily b (Pde4b) enzyme in gut dysbiosis induced neuro-inflammation and white matter loss following spinal cord i...

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Bibliographic Details
Main Authors: Scott A. Myers, Leila Gobejishvili, Sujata Saraswat Ohri, C. Garrett Wilson, Kariena R. Andres, Amberly S. Riegler, Hridgandh Donde, Swati Joshi-Barve, Shirish Barve, Scott R. Whittemore
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Neurobiology of Disease
Subjects:
Gut dysbiosis
Inflammation
ER stress response
Spinal cord injury
Endotoxemia
Phosphodiesterase 4B2
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118306314

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