The Synthesis and Absolute Configuration of Enantiomeric Pure (R)- and (S)-3-(piperidin-3-yl)-1H-Indole Derivatives

The Synthesis and Absolute Configuration of Enantiomeric Pure (R)- and (S)-3-(piperidin-3-yl)-1H-Indole Derivatives

This article describes the synthesis of new chiral 3-(piperidin-3-yl)-1H-indole derivatives <b>(R)-10a-c</b> and <b>(S)-11a-c</b> from the corresponding diastereomers: (3R, 2R) and (3S, 2R)-2-[3-(1H-indol-3-yl)-1-piperidyl]-2-phenyl-acetamides <b>(3R, 2R)-4a, (3R, 2R)-6...

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Bibliographic Details
Main Authors: Marek Król, Grzegorz Ślifirski, Jerzy Kleps, Piotr Podsadni, Ilona Materek, Anna E. Kozioł, Franciszek Herold
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
serotonin analogs
piperidin-3-yl-1H-indoles
enantiomers
chiral auxiliaries
HPLC separation
X-ray crystallography
Online Access:https://www.mdpi.com/1422-0067/24/1/517

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