| Summary: | The research includes 84 patients with leptospirosis treated in Clinic at Infectious Diseases – Pleven. Mild course in 52,38%, moderate in 19,05%, and severe in 28,57% are established. Serum amylase level has been investigated in 37 cases. Increased rates are measured in 41,67% of mild cases (av. 279 U/L), in 25% of moderate cases (av. 290 U/L), and in 88,24% of severe cases(av. 937 U/L). Significant difference between serum amylase levels of mild and severe cases is established (p < 0,02). Presumably immunological mechanisms of damage by participation of interleukins (IL1, IL6, IL8) and tumor necrosis factor (TNF-β) are in the base of increased serum amylase level in leptospirosis. The functional changes of pancreas in leptospirosis are not fully clear and further research is needed.
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