Insights into the Orchestration of Gene Transcription Regulators in <i>Helicobacter pylori</i>
Bacterial pathogens employ a general strategy to overcome host defenses by coordinating the virulence gene expression using dedicated regulatory systems that could raise intricate networks. During the last twenty years, many studies of <i>Helicobacter pylori</i>, a human pathogen respons...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/13688 |
| _version_ | 1797465162960076800 |
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| author | Andrea Vannini Davide Roncarati Federico D’Agostino Federico Antoniciello Vincenzo Scarlato |
| author_facet | Andrea Vannini Davide Roncarati Federico D’Agostino Federico Antoniciello Vincenzo Scarlato |
| author_sort | Andrea Vannini |
| collection | DOAJ |
| description | Bacterial pathogens employ a general strategy to overcome host defenses by coordinating the virulence gene expression using dedicated regulatory systems that could raise intricate networks. During the last twenty years, many studies of <i>Helicobacter pylori</i>, a human pathogen responsible for various stomach diseases, have mainly focused on elucidating the mechanisms and functions of virulence factors. In parallel, numerous studies have focused on the molecular mechanisms that regulate gene transcription to attempt to understand the physiological changes of the bacterium during infection and adaptation to the environmental conditions it encounters. The number of regulatory proteins deduced from the genome sequence analyses responsible for the correct orchestration of gene transcription appears limited to 14 regulators and three sigma factors. Furthermore, evidence is accumulating for new and complex circuits regulating gene transcription and <i>H. pylori</i> virulence. Here, we focus on the molecular mechanisms used by <i>H. pylori</i> to control gene transcription as a function of the principal environmental changes. |
| first_indexed | 2024-03-09T18:18:33Z |
| format | Article |
| id | doaj.art-5aaf5b4d16314f1288cd1fe0f4a15bda |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:18:33Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5aaf5b4d16314f1288cd1fe0f4a15bda2023-11-24T08:31:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221368810.3390/ijms232213688Insights into the Orchestration of Gene Transcription Regulators in <i>Helicobacter pylori</i>Andrea Vannini0Davide Roncarati1Federico D’Agostino2Federico Antoniciello3Vincenzo Scarlato4Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, 40126 Bologna, ItalyDepartment of Pharmacy and Biotechnology (FaBiT), University of Bologna, 40126 Bologna, ItalyDepartment of Pharmacy and Biotechnology (FaBiT), University of Bologna, 40126 Bologna, ItalyDepartment of Pharmacy and Biotechnology (FaBiT), University of Bologna, 40126 Bologna, ItalyDepartment of Pharmacy and Biotechnology (FaBiT), University of Bologna, 40126 Bologna, ItalyBacterial pathogens employ a general strategy to overcome host defenses by coordinating the virulence gene expression using dedicated regulatory systems that could raise intricate networks. During the last twenty years, many studies of <i>Helicobacter pylori</i>, a human pathogen responsible for various stomach diseases, have mainly focused on elucidating the mechanisms and functions of virulence factors. In parallel, numerous studies have focused on the molecular mechanisms that regulate gene transcription to attempt to understand the physiological changes of the bacterium during infection and adaptation to the environmental conditions it encounters. The number of regulatory proteins deduced from the genome sequence analyses responsible for the correct orchestration of gene transcription appears limited to 14 regulators and three sigma factors. Furthermore, evidence is accumulating for new and complex circuits regulating gene transcription and <i>H. pylori</i> virulence. Here, we focus on the molecular mechanisms used by <i>H. pylori</i> to control gene transcription as a function of the principal environmental changes.https://www.mdpi.com/1422-0067/23/22/13688<i>Helicobacter pylori</i>environmental responserepressors of transcriptionactivators of transcriptiontwo-component systems |
| spellingShingle | Andrea Vannini Davide Roncarati Federico D’Agostino Federico Antoniciello Vincenzo Scarlato Insights into the Orchestration of Gene Transcription Regulators in <i>Helicobacter pylori</i> International Journal of Molecular Sciences <i>Helicobacter pylori</i> environmental response repressors of transcription activators of transcription two-component systems |
| title | Insights into the Orchestration of Gene Transcription Regulators in <i>Helicobacter pylori</i> |
| title_full | Insights into the Orchestration of Gene Transcription Regulators in <i>Helicobacter pylori</i> |
| title_fullStr | Insights into the Orchestration of Gene Transcription Regulators in <i>Helicobacter pylori</i> |
| title_full_unstemmed | Insights into the Orchestration of Gene Transcription Regulators in <i>Helicobacter pylori</i> |
| title_short | Insights into the Orchestration of Gene Transcription Regulators in <i>Helicobacter pylori</i> |
| title_sort | insights into the orchestration of gene transcription regulators in i helicobacter pylori i |
| topic | <i>Helicobacter pylori</i> environmental response repressors of transcription activators of transcription two-component systems |
| url | https://www.mdpi.com/1422-0067/23/22/13688 |
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