Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein
The S1/S2 junction of the SARS-CoV-2 Spike protein is emerging as a key factor in virulence and pathogenesis. Here, the authors characterise an attenuated strain of SARS-CoV-2 with deletions in the critical S1/S2 junction and observe enhanced replication, generation of potent adaptive immunity but r...
Full description
Bibliographic Details
| Main Authors: |
Pui Wang,
Siu-Ying Lau,
Shaofeng Deng,
Pin Chen,
Bobo Wing-Yee Mok,
Anna Jinxia Zhang,
Andrew Chak-Yiu Lee,
Kwok-Hung Chan,
Rachel Chun-Yee Tam,
Haoran Xu,
Runhong Zhou,
Wenjun Song,
Li Liu,
Kelvin Kai-Wang To,
Jasper Fuk-Woo Chan,
Zhiwei Chen,
Kwok-Yung Yuen,
Honglin Chen |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2021-05-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-021-23166-0
|
|---|