Targeting NAD+ regeneration enhances antibiotic susceptibility of Streptococcus pneumoniae during invasive disease.

Targeting NAD+ regeneration enhances antibiotic susceptibility of Streptococcus pneumoniae during invasive disease.

Anaerobic bacteria are responsible for half of all pulmonary infections. One such pathogen is Streptococcus pneumoniae (Spn), a leading cause of community-acquired pneumonia, bacteremia/sepsis, and meningitis. Using a panel of isogenic mutants deficient in lactate, acetyl-CoA, and ethanol fermentati...

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Bibliographic Details
Main Authors: Hansol Im, Madison L Pearson, Eriel Martinez, Kyle H Cichos, Xiuhong Song, Katherine L Kruckow, Rachel M Andrews, Elie S Ghanem, Carlos J Orihuela
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-03-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002020

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