Interplay between Immune Cell Infiltration and Tumor Histological Subtype: A Case of Adrenocortical Cancer
The analysis of the tumor microenvironment, especially tumor-infiltrated immune cells, is essential for predicting tumor prognosis, clinical outcomes, and therapy strategies. Adrenocortical cancer is a rare nonimmunogenic malignancy in which the importance of the presence of immune cells is not well...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/21/5303 |
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| author | Apollinariya V. Bogolyubova Nano V. Pachuashvili Arina V. Tkachuk Natalia G. Mokrysheva Liliya S. Urusova |
| author_facet | Apollinariya V. Bogolyubova Nano V. Pachuashvili Arina V. Tkachuk Natalia G. Mokrysheva Liliya S. Urusova |
| author_sort | Apollinariya V. Bogolyubova |
| collection | DOAJ |
| description | The analysis of the tumor microenvironment, especially tumor-infiltrated immune cells, is essential for predicting tumor prognosis, clinical outcomes, and therapy strategies. Adrenocortical cancer is a rare nonimmunogenic malignancy in which the importance of the presence of immune cells is not well understood. In our study, we made the first attempt to understand the interplay between the histology of adrenocortical cancer and its immune landscape using cases from The Cancer Genome Atlas database and the Endocrinology Research Centre collection (Moscow, Russia). We showed that the oncocytic variant of adrenocortical cancer is characterized by intensive immune infiltration and better survival, and it is crucial to analyze the effect of immune infiltration independently for each histological variant. |
| first_indexed | 2024-03-09T19:12:13Z |
| format | Article |
| id | doaj.art-5ab3cc6b44fb418b8cedaee550e0056d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T19:12:13Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5ab3cc6b44fb418b8cedaee550e0056d2023-11-24T04:02:18ZengMDPI AGCancers2072-66942022-10-011421530310.3390/cancers14215303Interplay between Immune Cell Infiltration and Tumor Histological Subtype: A Case of Adrenocortical CancerApollinariya V. Bogolyubova0Nano V. Pachuashvili1Arina V. Tkachuk2Natalia G. Mokrysheva3Liliya S. Urusova4National Research Center for Hematology, 125167 Moscow, RussiaInstitute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, RussiaEndocrinology Research Centre, 117036 Moscow, RussiaEndocrinology Research Centre, 117036 Moscow, RussiaEndocrinology Research Centre, 117036 Moscow, RussiaThe analysis of the tumor microenvironment, especially tumor-infiltrated immune cells, is essential for predicting tumor prognosis, clinical outcomes, and therapy strategies. Adrenocortical cancer is a rare nonimmunogenic malignancy in which the importance of the presence of immune cells is not well understood. In our study, we made the first attempt to understand the interplay between the histology of adrenocortical cancer and its immune landscape using cases from The Cancer Genome Atlas database and the Endocrinology Research Centre collection (Moscow, Russia). We showed that the oncocytic variant of adrenocortical cancer is characterized by intensive immune infiltration and better survival, and it is crucial to analyze the effect of immune infiltration independently for each histological variant.https://www.mdpi.com/2072-6694/14/21/5303tumor microenvironmenttumor-infiltrated immune cellshistological variantadrenocortical canceroncocytic adrenocortical cancer |
| spellingShingle | Apollinariya V. Bogolyubova Nano V. Pachuashvili Arina V. Tkachuk Natalia G. Mokrysheva Liliya S. Urusova Interplay between Immune Cell Infiltration and Tumor Histological Subtype: A Case of Adrenocortical Cancer Cancers tumor microenvironment tumor-infiltrated immune cells histological variant adrenocortical cancer oncocytic adrenocortical cancer |
| title | Interplay between Immune Cell Infiltration and Tumor Histological Subtype: A Case of Adrenocortical Cancer |
| title_full | Interplay between Immune Cell Infiltration and Tumor Histological Subtype: A Case of Adrenocortical Cancer |
| title_fullStr | Interplay between Immune Cell Infiltration and Tumor Histological Subtype: A Case of Adrenocortical Cancer |
| title_full_unstemmed | Interplay between Immune Cell Infiltration and Tumor Histological Subtype: A Case of Adrenocortical Cancer |
| title_short | Interplay between Immune Cell Infiltration and Tumor Histological Subtype: A Case of Adrenocortical Cancer |
| title_sort | interplay between immune cell infiltration and tumor histological subtype a case of adrenocortical cancer |
| topic | tumor microenvironment tumor-infiltrated immune cells histological variant adrenocortical cancer oncocytic adrenocortical cancer |
| url | https://www.mdpi.com/2072-6694/14/21/5303 |
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