In Vitro Antitumor and Anti-Inflammatory Activities of <i>Allium</i>-Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS)
Increasing rates of cancer incidence and the side-effects of current chemotherapeutic treatments have led to the research on novel anticancer products based on dietary compounds. The use of <i>Allium</i> metabolites and extracts has been proposed to reduce the proliferation of tumor cell...
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MDPI AG
2023-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/6/1363 |
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| author | Enrique Guillamón Nuria Mut-Salud María Jesús Rodríguez-Sojo Antonio Jesús Ruiz-Malagón Antonio Cuberos-Escobar Antonio Martínez-Férez Alba Rodríguez-Nogales Julio Gálvez Alberto Baños |
| author_facet | Enrique Guillamón Nuria Mut-Salud María Jesús Rodríguez-Sojo Antonio Jesús Ruiz-Malagón Antonio Cuberos-Escobar Antonio Martínez-Férez Alba Rodríguez-Nogales Julio Gálvez Alberto Baños |
| author_sort | Enrique Guillamón |
| collection | DOAJ |
| description | Increasing rates of cancer incidence and the side-effects of current chemotherapeutic treatments have led to the research on novel anticancer products based on dietary compounds. The use of <i>Allium</i> metabolites and extracts has been proposed to reduce the proliferation of tumor cells by several mechanisms. In this study, we have shown the in vitro anti-proliferative and anti-inflammatory effect of two onion-derived metabolites propyl propane thiosulfinate (PTS) and propyl propane thiosulfonate (PTSO) on several human tumor lines (MCF-7, T-84, A-549, HT-29, Panc-1, Jurkat, PC-3, SW-837, and T1-73). We observed that this effect was related to their ability to induce apoptosis regulated by oxidative stress. In addition, both compounds were also able to reduce the levels of some pro-inflammatory cytokines, such as IL-8, IL-6, and IL-17. Therefore, PTS and PTSO may have a promising role in cancer prevention and/or treatment. |
| first_indexed | 2024-03-11T06:04:09Z |
| format | Article |
| id | doaj.art-5ab5d9b1a5a949908c618b5e83154af9 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T06:04:09Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-5ab5d9b1a5a949908c618b5e83154af92023-11-17T13:04:45ZengMDPI AGNutrients2072-66432023-03-01156136310.3390/nu15061363In Vitro Antitumor and Anti-Inflammatory Activities of <i>Allium</i>-Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS)Enrique Guillamón0Nuria Mut-Salud1María Jesús Rodríguez-Sojo2Antonio Jesús Ruiz-Malagón3Antonio Cuberos-Escobar4Antonio Martínez-Férez5Alba Rodríguez-Nogales6Julio Gálvez7Alberto Baños8DMC Research Center, 18620 Granada, SpainDMC Research Center, 18620 Granada, SpainDepartment of Pharmacology, Center for Biomedical Research (CIBM), Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), University of Granada, 18071 Granada, SpainDepartment of Pharmacology, Center for Biomedical Research (CIBM), Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), University of Granada, 18071 Granada, SpainPrimary Care, Andalusian Health Service District Malaga-Guadalhorce, 29004 Malaga, SpainChemical Engineering Department, University of Granada, Avenida Fuentenueva s/n, 18071 Granada, SpainDepartment of Pharmacology, Center for Biomedical Research (CIBM), Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), University of Granada, 18071 Granada, SpainDepartment of Pharmacology, Center for Biomedical Research (CIBM), Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), University of Granada, 18071 Granada, SpainDMC Research Center, 18620 Granada, SpainIncreasing rates of cancer incidence and the side-effects of current chemotherapeutic treatments have led to the research on novel anticancer products based on dietary compounds. The use of <i>Allium</i> metabolites and extracts has been proposed to reduce the proliferation of tumor cells by several mechanisms. In this study, we have shown the in vitro anti-proliferative and anti-inflammatory effect of two onion-derived metabolites propyl propane thiosulfinate (PTS) and propyl propane thiosulfonate (PTSO) on several human tumor lines (MCF-7, T-84, A-549, HT-29, Panc-1, Jurkat, PC-3, SW-837, and T1-73). We observed that this effect was related to their ability to induce apoptosis regulated by oxidative stress. In addition, both compounds were also able to reduce the levels of some pro-inflammatory cytokines, such as IL-8, IL-6, and IL-17. Therefore, PTS and PTSO may have a promising role in cancer prevention and/or treatment.https://www.mdpi.com/2072-6643/15/6/1363antitumoranti-inflammatory<i>Allium</i>organosulfur compounds |
| spellingShingle | Enrique Guillamón Nuria Mut-Salud María Jesús Rodríguez-Sojo Antonio Jesús Ruiz-Malagón Antonio Cuberos-Escobar Antonio Martínez-Férez Alba Rodríguez-Nogales Julio Gálvez Alberto Baños In Vitro Antitumor and Anti-Inflammatory Activities of <i>Allium</i>-Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS) Nutrients antitumor anti-inflammatory <i>Allium</i> organosulfur compounds |
| title | In Vitro Antitumor and Anti-Inflammatory Activities of <i>Allium</i>-Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS) |
| title_full | In Vitro Antitumor and Anti-Inflammatory Activities of <i>Allium</i>-Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS) |
| title_fullStr | In Vitro Antitumor and Anti-Inflammatory Activities of <i>Allium</i>-Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS) |
| title_full_unstemmed | In Vitro Antitumor and Anti-Inflammatory Activities of <i>Allium</i>-Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS) |
| title_short | In Vitro Antitumor and Anti-Inflammatory Activities of <i>Allium</i>-Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS) |
| title_sort | in vitro antitumor and anti inflammatory activities of i allium i derived compounds propyl propane thiosulfonate ptso and propyl propane thiosulfinate pts |
| topic | antitumor anti-inflammatory <i>Allium</i> organosulfur compounds |
| url | https://www.mdpi.com/2072-6643/15/6/1363 |
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