Normative reference values for the dorsal sural nerve derived from a large multicenter cohort
Objectives: Dorsal sural nerve conduction studies (NCS) may increase the sensitivity for the diagnosis of polyneuropathy, but clinical use is limited by a lack of reliable normative reference values in all age-groups. The aim of our study was to develop reference values for the dorsal sural nerve, b...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Clinical Neurophysiology Practice |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2467981X21000391 |
| _version_ | 1819101955833724928 |
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| author | Thomas Krøigård Sandra S. Gylfadottir Mustapha Itani Karolina S. Khan Henning Andersen Søren H. Sindrup Troels S. Jensen Kjeld V. Andersen Hatice Tankisi Sándor Beniczky Alexander Gramm Kristensen |
| author_facet | Thomas Krøigård Sandra S. Gylfadottir Mustapha Itani Karolina S. Khan Henning Andersen Søren H. Sindrup Troels S. Jensen Kjeld V. Andersen Hatice Tankisi Sándor Beniczky Alexander Gramm Kristensen |
| author_sort | Thomas Krøigård |
| collection | DOAJ |
| description | Objectives: Dorsal sural nerve conduction studies (NCS) may increase the sensitivity for the diagnosis of polyneuropathy, but clinical use is limited by a lack of reliable normative reference values in all age-groups. The aim of our study was to develop reference values for the dorsal sural nerve, based on a large multicenter cohort of healthy subjects. Methods: Bilateral antidromic NCS were performed using standard surface electrodes in 229 healthy subjects (aged 21–80 years; median: 54 years). We assessed the normality of data distribution for amplitudes and conduction velocity (CV) and for their logarithmic (ln) transformation. The effects of age and height were determined using linear regression analysis. Results: Sensory potentials were present in all subjects. Logarithmically transformed data were normally distributed. Age2 and height were most significantly associated with amplitude, and age and height with CV, respectively. There was no significant side-difference. Mean amplitudes (right and left) were 4.8 and 4.9 μV and mean CV 46.7 and 46.9 m/s. Reference limits were e (3.712515 – 0.0000956 * age2 – 0.0115883 * height ± 1.96 * 0.51137) for amplitude and e (4.354374 – 0.0021081 * age – 0.0023354 * height ± 1.96 * 0.11161) for CV. Conclusions: Dorsal sural nerve NCS are robust and have well defined normative limits. Significance: The findings provide a basis for more sensitive NCS in clinical practice and future studies of the diagnostic accuracy of NCS in polyneuropathy. |
| first_indexed | 2024-12-22T01:26:54Z |
| format | Article |
| id | doaj.art-5ab7382a54034d67a63f02c2e3275500 |
| institution | Directory Open Access Journal |
| issn | 2467-981X |
| language | English |
| last_indexed | 2024-12-22T01:26:54Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Neurophysiology Practice |
| spelling | doaj.art-5ab7382a54034d67a63f02c2e32755002022-12-21T18:43:36ZengElsevierClinical Neurophysiology Practice2467-981X2021-01-016239243Normative reference values for the dorsal sural nerve derived from a large multicenter cohortThomas Krøigård0Sandra S. Gylfadottir1Mustapha Itani2Karolina S. Khan3Henning Andersen4Søren H. Sindrup5Troels S. Jensen6Kjeld V. Andersen7Hatice Tankisi8Sándor Beniczky9Alexander Gramm Kristensen10Research Unit for Neurology, Odense University Hospital, Odense, Denmark; University of Southern Denmark, Odense, Denmark; Corresponding author at: Research Unit for Neurology, Odense University Hospital, J. B. Winsløws Vej 4, 5000 Odense C, Denmark.Department of Neurology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkResearch Unit for Neurology, Odense University Hospital, Odense, Denmark; University of Southern Denmark, Odense, DenmarkDepartment of Neurology, Aarhus University Hospital, Aarhus University, Aarhus, DenmarkDepartment of Neurology, Aarhus University Hospital, Aarhus University, Aarhus, DenmarkResearch Unit for Neurology, Odense University Hospital, Odense, Denmark; University of Southern Denmark, Odense, DenmarkDepartment of Neurology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkAleris-Hamlet Hospital, Søborg, DenmarkDepartment of Clinical Neurophysiology, Aarhus University Hospital, Aarhus University, Aarhus, DenmarkDepartment of Clinical Neurophysiology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark; Department of Clinical Neurophysiology, Danish Epilepsy Centre (Member of the ERN EpiCARE), Dianalund, DenmarkDepartment of Clinical Neurophysiology, Aarhus University Hospital, Aarhus University, Aarhus, DenmarkObjectives: Dorsal sural nerve conduction studies (NCS) may increase the sensitivity for the diagnosis of polyneuropathy, but clinical use is limited by a lack of reliable normative reference values in all age-groups. The aim of our study was to develop reference values for the dorsal sural nerve, based on a large multicenter cohort of healthy subjects. Methods: Bilateral antidromic NCS were performed using standard surface electrodes in 229 healthy subjects (aged 21–80 years; median: 54 years). We assessed the normality of data distribution for amplitudes and conduction velocity (CV) and for their logarithmic (ln) transformation. The effects of age and height were determined using linear regression analysis. Results: Sensory potentials were present in all subjects. Logarithmically transformed data were normally distributed. Age2 and height were most significantly associated with amplitude, and age and height with CV, respectively. There was no significant side-difference. Mean amplitudes (right and left) were 4.8 and 4.9 μV and mean CV 46.7 and 46.9 m/s. Reference limits were e (3.712515 – 0.0000956 * age2 – 0.0115883 * height ± 1.96 * 0.51137) for amplitude and e (4.354374 – 0.0021081 * age – 0.0023354 * height ± 1.96 * 0.11161) for CV. Conclusions: Dorsal sural nerve NCS are robust and have well defined normative limits. Significance: The findings provide a basis for more sensitive NCS in clinical practice and future studies of the diagnostic accuracy of NCS in polyneuropathy.http://www.sciencedirect.com/science/article/pii/S2467981X21000391DiagnosisDorsal sural nerveNerve conduction studiesPolyneuropathyReference values |
| spellingShingle | Thomas Krøigård Sandra S. Gylfadottir Mustapha Itani Karolina S. Khan Henning Andersen Søren H. Sindrup Troels S. Jensen Kjeld V. Andersen Hatice Tankisi Sándor Beniczky Alexander Gramm Kristensen Normative reference values for the dorsal sural nerve derived from a large multicenter cohort Clinical Neurophysiology Practice Diagnosis Dorsal sural nerve Nerve conduction studies Polyneuropathy Reference values |
| title | Normative reference values for the dorsal sural nerve derived from a large multicenter cohort |
| title_full | Normative reference values for the dorsal sural nerve derived from a large multicenter cohort |
| title_fullStr | Normative reference values for the dorsal sural nerve derived from a large multicenter cohort |
| title_full_unstemmed | Normative reference values for the dorsal sural nerve derived from a large multicenter cohort |
| title_short | Normative reference values for the dorsal sural nerve derived from a large multicenter cohort |
| title_sort | normative reference values for the dorsal sural nerve derived from a large multicenter cohort |
| topic | Diagnosis Dorsal sural nerve Nerve conduction studies Polyneuropathy Reference values |
| url | http://www.sciencedirect.com/science/article/pii/S2467981X21000391 |
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