Multiple flow rate modelling of nitric oxide in COPD – methodological concerns
Multiple flow rates FeNO data two-compartment mathematical modelling can estimate NO airway wall concentration (CawNO), airway wall diffusing capacity (DawNO), alveolar concentration (CalvNO) and maximal NO flux (JawNO). To compare modelling based on linear, non linear and mixed linear and non linea...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2006-12-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/cgi/content/full/15/101/213 |
| _version_ | 1811313594015416320 |
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| author | Kay Roy Zoe Borrill Andrew Hazel Jorgen Vestbo Dave Singh |
| author_facet | Kay Roy Zoe Borrill Andrew Hazel Jorgen Vestbo Dave Singh |
| author_sort | Kay Roy |
| collection | DOAJ |
| description | Multiple flow rates FeNO data two-compartment mathematical modelling can estimate NO airway wall concentration (CawNO), airway wall diffusing capacity (DawNO), alveolar concentration (CalvNO) and maximal NO flux (JawNO). To compare modelling based on linear, non linear and mixed linear and non linear analyses in COPD. FeNO was measured using the Niox analyser (Aerocrine) at flow rates: 10, 30, 50, 100 and 200ml/s in 50 COPD patients and the data applied to 4 different methods. All methods showed that current smoking reduced CawNO. JawNO data differed between methods (Table 1). All the methods showed that current smoking did not affect CalvNO or DawNO. Comparison of the methods showed that CalvNO and DawNO data were significantly different between all methods, JawNO was different for most between method comparisons, while there was agreement between all the methods for CawNO. Smoking in COPD reduces CawNO , but not CalvNO and DawNO. JawNO, CalvNO and DawNO data are model dependent parameters. CawNO findings were model independent, and hence the most robust modelled parameter. |
| first_indexed | 2024-04-13T10:57:16Z |
| format | Article |
| id | doaj.art-5ab93eb7c43948cf929a6920cc8e8205 |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-04-13T10:57:16Z |
| publishDate | 2006-12-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-5ab93eb7c43948cf929a6920cc8e82052022-12-22T02:49:30ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172006-12-0115101213214Multiple flow rate modelling of nitric oxide in COPD – methodological concernsKay RoyZoe BorrillAndrew HazelJorgen VestboDave SinghMultiple flow rates FeNO data two-compartment mathematical modelling can estimate NO airway wall concentration (CawNO), airway wall diffusing capacity (DawNO), alveolar concentration (CalvNO) and maximal NO flux (JawNO). To compare modelling based on linear, non linear and mixed linear and non linear analyses in COPD. FeNO was measured using the Niox analyser (Aerocrine) at flow rates: 10, 30, 50, 100 and 200ml/s in 50 COPD patients and the data applied to 4 different methods. All methods showed that current smoking reduced CawNO. JawNO data differed between methods (Table 1). All the methods showed that current smoking did not affect CalvNO or DawNO. Comparison of the methods showed that CalvNO and DawNO data were significantly different between all methods, JawNO was different for most between method comparisons, while there was agreement between all the methods for CawNO. Smoking in COPD reduces CawNO , but not CalvNO and DawNO. JawNO, CalvNO and DawNO data are model dependent parameters. CawNO findings were model independent, and hence the most robust modelled parameter.http://err.ersjournals.com/cgi/content/full/15/101/213 |
| spellingShingle | Kay Roy Zoe Borrill Andrew Hazel Jorgen Vestbo Dave Singh Multiple flow rate modelling of nitric oxide in COPD – methodological concerns European Respiratory Review |
| title | Multiple flow rate modelling of nitric oxide in COPD – methodological concerns |
| title_full | Multiple flow rate modelling of nitric oxide in COPD – methodological concerns |
| title_fullStr | Multiple flow rate modelling of nitric oxide in COPD – methodological concerns |
| title_full_unstemmed | Multiple flow rate modelling of nitric oxide in COPD – methodological concerns |
| title_short | Multiple flow rate modelling of nitric oxide in COPD – methodological concerns |
| title_sort | multiple flow rate modelling of nitric oxide in copd methodological concerns |
| url | http://err.ersjournals.com/cgi/content/full/15/101/213 |
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