Serological Analysis Identifies Consequential B Cell Epitopes on the Flexible Linker and C-Terminus of Decorin Binding Protein A (DbpA) from Borrelia burgdorferi

Serological Analysis Identifies Consequential B Cell Epitopes on the Flexible Linker and C-Terminus of Decorin Binding Protein A (DbpA) from Borrelia burgdorferi

ABSTRACT Decorin binding protein A (DbpA) is a surface adhesin of Borrelia burgdorferi, the causative agent of Lyme disease. While DbpA is one of the most immunogenic of B. burgdorferi’s nearly 100 lipoproteins, the B cell epitopes on DbpA recognized by humans following B. burgdorferi infection have...

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Bibliographic Details
Main Authors: Elaheh Movahed, David J. Vance, Dylan Ehrbar, Greta Van Slyke, Jennifer Yates, Karen Kullas, Michael Rudolph, Nicholas J. Mantis
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mSphere
Subjects:
Lyme disease
antibody
epitope
vaccine
Borrelia burgdorferi
antibody function
Online Access:https://journals.asm.org/doi/10.1128/msphere.00252-22

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