Ameliorating effect of Berberis lycium root bark extracts against cisplatin-induced nephropathy in rat
The aim of this study was to investigate the sub-acute nephroprotective effect of Berberis lycium root bark extracts against cisplatin-induced nephrotoxicity. Aqueous and methanol extracts (200 and 400 mg/kg) were co-administered with cisplatin (4 mg/kg) for 19 days. Results showed that cisplatin si...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2018-08-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/36705 |
| _version_ | 1818269858850144256 |
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| author | Rukhsana Anwar Rabeea Sultan Fasiha Batool |
| author_facet | Rukhsana Anwar Rabeea Sultan Fasiha Batool |
| author_sort | Rukhsana Anwar |
| collection | DOAJ |
| description | The aim of this study was to investigate the sub-acute nephroprotective effect of Berberis lycium root bark extracts against cisplatin-induced nephrotoxicity. Aqueous and methanol extracts (200 and 400 mg/kg) were co-administered with cisplatin (4 mg/kg) for 19 days. Results showed that cisplatin significantly (ap<0.05) raised the serum creatinine, uric acid, urea level as well as tissue MDA level as compared to control group. It decreased GST activity, tGSH and catalase activity in rats. Both extracts significantly reduced the serum creatinine, urea and uric acid levels. Moreover, GST, CAT activity and tGSH content were significantly (p<0.05) increased and MDA level was decreased. Histopathological examination showed that both extracts efficiently reversed the morphological changes and damage induced by cisplatin. It is concluded that both extracts of B. lycium root bark possess nephroprotective effect against cisplatin-induced nephrotoxicity.
Video Clip of Methodology:
Histological study of rat kidney: 14 min 02 sec Full Screen Alternate |
| first_indexed | 2024-12-12T21:01:04Z |
| format | Article |
| id | doaj.art-5aba632286854d37abd7645c40b49e00 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-12T21:01:04Z |
| publishDate | 2018-08-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-5aba632286854d37abd7645c40b49e002022-12-22T00:12:08ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882018-08-0113310.3329/bjp.v13i3.3670524270Ameliorating effect of Berberis lycium root bark extracts against cisplatin-induced nephropathy in ratRukhsana Anwar0Rabeea Sultan1Fasiha Batool2Department of Pharmacology, University College of Pharmacy, University of the Punjab, Lahore 54000Department of Pharmacology, University College of Pharmacy, University of the Punjab, Lahore 54000Department of Pharmacology, University College of Pharmacy, University of the Punjab, Lahore 54000The aim of this study was to investigate the sub-acute nephroprotective effect of Berberis lycium root bark extracts against cisplatin-induced nephrotoxicity. Aqueous and methanol extracts (200 and 400 mg/kg) were co-administered with cisplatin (4 mg/kg) for 19 days. Results showed that cisplatin significantly (ap<0.05) raised the serum creatinine, uric acid, urea level as well as tissue MDA level as compared to control group. It decreased GST activity, tGSH and catalase activity in rats. Both extracts significantly reduced the serum creatinine, urea and uric acid levels. Moreover, GST, CAT activity and tGSH content were significantly (p<0.05) increased and MDA level was decreased. Histopathological examination showed that both extracts efficiently reversed the morphological changes and damage induced by cisplatin. It is concluded that both extracts of B. lycium root bark possess nephroprotective effect against cisplatin-induced nephrotoxicity. Video Clip of Methodology: Histological study of rat kidney: 14 min 02 sec Full Screen Alternatehttps://www.banglajol.info/index.php/BJP/article/view/36705Berberis lyceumCisplatinNephrotoxicityOxidative stress |
| spellingShingle | Rukhsana Anwar Rabeea Sultan Fasiha Batool Ameliorating effect of Berberis lycium root bark extracts against cisplatin-induced nephropathy in rat Bangladesh Journal of Pharmacology Berberis lyceum Cisplatin Nephrotoxicity Oxidative stress |
| title | Ameliorating effect of Berberis lycium root bark extracts against cisplatin-induced nephropathy in rat |
| title_full | Ameliorating effect of Berberis lycium root bark extracts against cisplatin-induced nephropathy in rat |
| title_fullStr | Ameliorating effect of Berberis lycium root bark extracts against cisplatin-induced nephropathy in rat |
| title_full_unstemmed | Ameliorating effect of Berberis lycium root bark extracts against cisplatin-induced nephropathy in rat |
| title_short | Ameliorating effect of Berberis lycium root bark extracts against cisplatin-induced nephropathy in rat |
| title_sort | ameliorating effect of berberis lycium root bark extracts against cisplatin induced nephropathy in rat |
| topic | Berberis lyceum Cisplatin Nephrotoxicity Oxidative stress |
| url | https://www.banglajol.info/index.php/BJP/article/view/36705 |
| work_keys_str_mv | AT rukhsanaanwar amelioratingeffectofberberislyciumrootbarkextractsagainstcisplatininducednephropathyinrat AT rabeeasultan amelioratingeffectofberberislyciumrootbarkextractsagainstcisplatininducednephropathyinrat AT fasihabatool amelioratingeffectofberberislyciumrootbarkextractsagainstcisplatininducednephropathyinrat |