Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art
Biopolymeric nanoparticulate systems hold favorable carrier properties for active delivery. The enhancement in the research interest in alginate formulations in biomedical and pharmaceutical research, owing to its biodegradable, biocompatible, and bioadhesive characteristics, reiterates its future u...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/16/9035 |
| _version_ | 1797409808232480768 |
|---|---|
| author | Mohammad A. S. Abourehab Rahul R. Rajendran Anshul Singh Sheersha Pramanik Prachi Shrivastav Mohammad Javed Ansari Ravi Manne Larissa Souza Amaral A. Deepak |
| author_facet | Mohammad A. S. Abourehab Rahul R. Rajendran Anshul Singh Sheersha Pramanik Prachi Shrivastav Mohammad Javed Ansari Ravi Manne Larissa Souza Amaral A. Deepak |
| author_sort | Mohammad A. S. Abourehab |
| collection | DOAJ |
| description | Biopolymeric nanoparticulate systems hold favorable carrier properties for active delivery. The enhancement in the research interest in alginate formulations in biomedical and pharmaceutical research, owing to its biodegradable, biocompatible, and bioadhesive characteristics, reiterates its future use as an efficient drug delivery matrix. Alginates, obtained from natural sources, are the colloidal polysaccharide group, which are water-soluble, non-toxic, and non-irritant. These are linear copolymeric blocks of α-(1→4)-linked l-guluronic acid (G) and β-(1→4)-linked d-mannuronic acid (M) residues. Owing to the monosaccharide sequencing and the enzymatically governed reactions, alginates are well-known as an essential bio-polymer group for multifarious biomedical implementations. Additionally, alginate’s bio-adhesive property makes it significant in the pharmaceutical industry. Alginate has shown immense potential in wound healing and drug delivery applications to date because its gel-forming ability maintains the structural resemblance to the extracellular matrices in tissues and can be altered to perform numerous crucial functions. The initial section of this review will deliver a perception of the extraction source and alginate’s remarkable properties. Furthermore, we have aspired to discuss the current literature on alginate utilization as a biopolymeric carrier for drug delivery through numerous administration routes. Finally, the latest investigations on alginate composite utilization in wound healing are addressed. |
| first_indexed | 2024-03-09T04:20:53Z |
| format | Article |
| id | doaj.art-5abb119236a14a77ae54144056b332ed |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:20:53Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5abb119236a14a77ae54144056b332ed2023-12-03T13:48:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012316903510.3390/ijms23169035Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-ArtMohammad A. S. Abourehab0Rahul R. Rajendran1Anshul Singh2Sheersha Pramanik3Prachi Shrivastav4Mohammad Javed Ansari5Ravi Manne6Larissa Souza Amaral7A. Deepak8Department of Pharmaceutics, College of Pharmacy, Umm Al Qura University, Makkah 21955, Saudi ArabiaDepartment of Mechanical Engineering and Mechanics, Lehigh University, 19 Memorial Drive West, Bethlehem, PA 18015, USADepartment of Chemistry, Baba Mastnath University, Rohtak 124021, Haryana, IndiaDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, Tamil Nadu, IndiaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Mohali 160062, Punjab, IndiaDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi ArabiaChemtex Environmental Lab, Quality Control and Assurance Department, 3082 25th Street, Port Arthur, TX 77642, USADepartment of Bioengineering, University of São Paulo (USP), Av. Trabalhador São Carlense, 400, São Carlos 13566590, SP, BrazilSaveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai 600128, Tamil Nadu, IndiaBiopolymeric nanoparticulate systems hold favorable carrier properties for active delivery. The enhancement in the research interest in alginate formulations in biomedical and pharmaceutical research, owing to its biodegradable, biocompatible, and bioadhesive characteristics, reiterates its future use as an efficient drug delivery matrix. Alginates, obtained from natural sources, are the colloidal polysaccharide group, which are water-soluble, non-toxic, and non-irritant. These are linear copolymeric blocks of α-(1→4)-linked l-guluronic acid (G) and β-(1→4)-linked d-mannuronic acid (M) residues. Owing to the monosaccharide sequencing and the enzymatically governed reactions, alginates are well-known as an essential bio-polymer group for multifarious biomedical implementations. Additionally, alginate’s bio-adhesive property makes it significant in the pharmaceutical industry. Alginate has shown immense potential in wound healing and drug delivery applications to date because its gel-forming ability maintains the structural resemblance to the extracellular matrices in tissues and can be altered to perform numerous crucial functions. The initial section of this review will deliver a perception of the extraction source and alginate’s remarkable properties. Furthermore, we have aspired to discuss the current literature on alginate utilization as a biopolymeric carrier for drug delivery through numerous administration routes. Finally, the latest investigations on alginate composite utilization in wound healing are addressed.https://www.mdpi.com/1422-0067/23/16/9035alginatedrug delivery systemformulationsadministration routecontrolled releasewound healing |
| spellingShingle | Mohammad A. S. Abourehab Rahul R. Rajendran Anshul Singh Sheersha Pramanik Prachi Shrivastav Mohammad Javed Ansari Ravi Manne Larissa Souza Amaral A. Deepak Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art International Journal of Molecular Sciences alginate drug delivery system formulations administration route controlled release wound healing |
| title | Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art |
| title_full | Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art |
| title_fullStr | Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art |
| title_full_unstemmed | Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art |
| title_short | Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art |
| title_sort | alginate as a promising biopolymer in drug delivery and wound healing a review of the state of the art |
| topic | alginate drug delivery system formulations administration route controlled release wound healing |
| url | https://www.mdpi.com/1422-0067/23/16/9035 |
| work_keys_str_mv | AT mohammadasabourehab alginateasapromisingbiopolymerindrugdeliveryandwoundhealingareviewofthestateoftheart AT rahulrrajendran alginateasapromisingbiopolymerindrugdeliveryandwoundhealingareviewofthestateoftheart AT anshulsingh alginateasapromisingbiopolymerindrugdeliveryandwoundhealingareviewofthestateoftheart AT sheershapramanik alginateasapromisingbiopolymerindrugdeliveryandwoundhealingareviewofthestateoftheart AT prachishrivastav alginateasapromisingbiopolymerindrugdeliveryandwoundhealingareviewofthestateoftheart AT mohammadjavedansari alginateasapromisingbiopolymerindrugdeliveryandwoundhealingareviewofthestateoftheart AT ravimanne alginateasapromisingbiopolymerindrugdeliveryandwoundhealingareviewofthestateoftheart AT larissasouzaamaral alginateasapromisingbiopolymerindrugdeliveryandwoundhealingareviewofthestateoftheart AT adeepak alginateasapromisingbiopolymerindrugdeliveryandwoundhealingareviewofthestateoftheart |