Parametric analysis of the ionic concentrations effects in the behavior of the sinoatrial node
A sensibility study on the effect of ionic concentrations in the behavior of the sinoatrial node was carried out. The study was based on the model proposed by H. Zhang, A. V. Holden and M.R. Boyett. It was simplified using concepts of experimental design. The study was developed on a set of eight c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universidad de Antioquia
2013-12-01
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| Series: | Revista Facultad de Ingeniería Universidad de Antioquia |
| Subjects: | |
| Online Access: | https://revistas.udea.edu.co/index.php/ingenieria/article/view/17966 |
| _version_ | 1797861685945434112 |
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| author | Daniel Alfonso Sierra Oscar Leonel Rueda Carlos Rodrigo Correa |
| author_facet | Daniel Alfonso Sierra Oscar Leonel Rueda Carlos Rodrigo Correa |
| author_sort | Daniel Alfonso Sierra |
| collection | DOAJ |
| description |
A sensibility study on the effect of ionic concentrations in the behavior of the sinoatrial node was carried out. The study was based on the model proposed by H. Zhang, A. V. Holden and M.R. Boyett. It was simplified using concepts of experimental design. The study was developed on a set of eight characteristics that describe the action potential generated by the sinoatrial node, for both the central and peripheral cells. The sensibility analysis shows that the sodium and potassium ionic concentrations should be controlled to maintain the normal behavior of the node. On the other hand, the simulated changes in calcium concentrations do not produce significant effects on the node operation. Finally, a response surface model was developed as a simplification of the original model. This response surfaces simplified model may be used in the on-line estimation of the operation characteristics of the in vitro sinoatrial node. From the computational point of view, and using the simplification strategy described above, the processing model time was decreased as a 1 to 50 ratio.
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| first_indexed | 2024-04-09T22:08:14Z |
| format | Article |
| id | doaj.art-5abd6f87371149a49c00572b13527035 |
| institution | Directory Open Access Journal |
| issn | 0120-6230 2422-2844 |
| language | English |
| last_indexed | 2024-04-09T22:08:14Z |
| publishDate | 2013-12-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Revista Facultad de Ingeniería Universidad de Antioquia |
| spelling | doaj.art-5abd6f87371149a49c00572b135270352023-03-23T12:33:41ZengUniversidad de AntioquiaRevista Facultad de Ingeniería Universidad de Antioquia0120-62302422-28442013-12-014510.17533/udea.redin.17966Parametric analysis of the ionic concentrations effects in the behavior of the sinoatrial nodeDaniel Alfonso Sierra0Oscar Leonel Rueda1Carlos Rodrigo Correa 2Universidad Industrial de SantanderUniversidad Industrial de SantanderUniversidad Industrial de Santander A sensibility study on the effect of ionic concentrations in the behavior of the sinoatrial node was carried out. The study was based on the model proposed by H. Zhang, A. V. Holden and M.R. Boyett. It was simplified using concepts of experimental design. The study was developed on a set of eight characteristics that describe the action potential generated by the sinoatrial node, for both the central and peripheral cells. The sensibility analysis shows that the sodium and potassium ionic concentrations should be controlled to maintain the normal behavior of the node. On the other hand, the simulated changes in calcium concentrations do not produce significant effects on the node operation. Finally, a response surface model was developed as a simplification of the original model. This response surfaces simplified model may be used in the on-line estimation of the operation characteristics of the in vitro sinoatrial node. From the computational point of view, and using the simplification strategy described above, the processing model time was decreased as a 1 to 50 ratio. https://revistas.udea.edu.co/index.php/ingenieria/article/view/17966Ionic concentrationsmodelingaction potentialsparametric sensitivityresponse surfaces |
| spellingShingle | Daniel Alfonso Sierra Oscar Leonel Rueda Carlos Rodrigo Correa Parametric analysis of the ionic concentrations effects in the behavior of the sinoatrial node Revista Facultad de Ingeniería Universidad de Antioquia Ionic concentrations modeling action potentials parametric sensitivity response surfaces |
| title | Parametric analysis of the ionic concentrations effects in the behavior of the sinoatrial node |
| title_full | Parametric analysis of the ionic concentrations effects in the behavior of the sinoatrial node |
| title_fullStr | Parametric analysis of the ionic concentrations effects in the behavior of the sinoatrial node |
| title_full_unstemmed | Parametric analysis of the ionic concentrations effects in the behavior of the sinoatrial node |
| title_short | Parametric analysis of the ionic concentrations effects in the behavior of the sinoatrial node |
| title_sort | parametric analysis of the ionic concentrations effects in the behavior of the sinoatrial node |
| topic | Ionic concentrations modeling action potentials parametric sensitivity response surfaces |
| url | https://revistas.udea.edu.co/index.php/ingenieria/article/view/17966 |
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