Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers
Abstract The role of differential cytology patterns in peripheral blood and bronchoalveolar lavage samples is increasingly investigated as a potential adjunct to diagnose acute and chronic allograft dysfunction after lung transplantation. While these profiles might facilitate the diagnosis of acute...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12931-017-0634-6 |
| _version_ | 1818243271162331136 |
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| author | Nicole E. Speck Macé M. Schuurmans Christian Benden Cécile A. Robinson Lars C. Huber |
| author_facet | Nicole E. Speck Macé M. Schuurmans Christian Benden Cécile A. Robinson Lars C. Huber |
| author_sort | Nicole E. Speck |
| collection | DOAJ |
| description | Abstract The role of differential cytology patterns in peripheral blood and bronchoalveolar lavage samples is increasingly investigated as a potential adjunct to diagnose acute and chronic allograft dysfunction after lung transplantation. While these profiles might facilitate the diagnosis of acute cellular rejection, low sensitivity and specificity of these patterns limit direct translation in a clinical setting. In this context, the identification of other biomarkers is needed. This review article gives an overview of cytokine profiles of plasma and bronchoalveolar lavage samples during acute cellular rejection. The value of these cytokines in supporting the diagnosis of acute cellular rejection is discussed. Current findings on the topic are highlighted and experimental settings for future research projects are identified. |
| first_indexed | 2024-12-12T13:58:28Z |
| format | Article |
| id | doaj.art-5abe0719a33e4faa8a32372c5f4ae78f |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-12T13:58:28Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-5abe0719a33e4faa8a32372c5f4ae78f2022-12-22T00:22:24ZengBMCRespiratory Research1465-993X2017-08-0118111310.1186/s12931-017-0634-6Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markersNicole E. Speck0Macé M. Schuurmans1Christian Benden2Cécile A. Robinson3Lars C. Huber4Division of Pulmonology, University Hospital ZurichDivision of Pulmonology, University Hospital ZurichDivision of Pulmonology, University Hospital ZurichDivision of Pulmonology, University Hospital ZurichClinic for Internal Medicine, City Hospital TriemliAbstract The role of differential cytology patterns in peripheral blood and bronchoalveolar lavage samples is increasingly investigated as a potential adjunct to diagnose acute and chronic allograft dysfunction after lung transplantation. While these profiles might facilitate the diagnosis of acute cellular rejection, low sensitivity and specificity of these patterns limit direct translation in a clinical setting. In this context, the identification of other biomarkers is needed. This review article gives an overview of cytokine profiles of plasma and bronchoalveolar lavage samples during acute cellular rejection. The value of these cytokines in supporting the diagnosis of acute cellular rejection is discussed. Current findings on the topic are highlighted and experimental settings for future research projects are identified.http://link.springer.com/article/10.1186/s12931-017-0634-6BloodBronchoalveolar lavageCytokineDiagnosisGraft rejectionLung transplantation |
| spellingShingle | Nicole E. Speck Macé M. Schuurmans Christian Benden Cécile A. Robinson Lars C. Huber Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers Respiratory Research Blood Bronchoalveolar lavage Cytokine Diagnosis Graft rejection Lung transplantation |
| title | Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers |
| title_full | Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers |
| title_fullStr | Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers |
| title_full_unstemmed | Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers |
| title_short | Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers |
| title_sort | plasma and bronchoalveolar lavage samples in acute lung allograft rejection the potential role of cytokines as diagnostic markers |
| topic | Blood Bronchoalveolar lavage Cytokine Diagnosis Graft rejection Lung transplantation |
| url | http://link.springer.com/article/10.1186/s12931-017-0634-6 |
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