A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model
Curcumin has been reported to improve or prevent movement disorders in Parkinson’s disease (PD); however, its low bioavailability is the biggest obstacle to its application. To optimize the limited efficacy of curcumin and to improve its protective effects against PD, we prepared and tested a novel...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.984895/full |
| _version_ | 1811223315643105280 |
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| author | Xiwen Geng Xiwen Geng Xiwen Geng Hao Zhang Hao Zhang Hao Zhang Minghui Hu Minghui Hu Minghui Hu Xiaoyu Liu Min Han Jinlu Xie Zifa Li Zifa Li Zifa Li Feng Zhao Feng Zhao Feng Zhao Wei Liu Sheng Wei Sheng Wei Sheng Wei |
| author_facet | Xiwen Geng Xiwen Geng Xiwen Geng Hao Zhang Hao Zhang Hao Zhang Minghui Hu Minghui Hu Minghui Hu Xiaoyu Liu Min Han Jinlu Xie Zifa Li Zifa Li Zifa Li Feng Zhao Feng Zhao Feng Zhao Wei Liu Sheng Wei Sheng Wei Sheng Wei |
| author_sort | Xiwen Geng |
| collection | DOAJ |
| description | Curcumin has been reported to improve or prevent movement disorders in Parkinson’s disease (PD); however, its low bioavailability is the biggest obstacle to its application. To optimize the limited efficacy of curcumin and to improve its protective effects against PD, we prepared and tested a novel curcumin oil solution. In vivo imaging was used to confirm that the curcumin oil solution has higher bioavailability than curcumin alone. To test its motor effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced movement disorders, behavioral tests, including the open-field test, pole test, rotarod test, and automated gait analysis were used. Finally, pathological evaluation using immunohistochemistry and western blotting analysis was done. Encouragingly, the behavioral test findings exhibited a better protective effect against MPTP-induced movement disorders. In addition, it had a greater protective effect on dopaminergic neurons in the compact part of the substantia nigra along with the PD process according to pathological evaluation. This novel curcumin oil solution may provide a new choice for PD prevention as a dietary supplement or clinically assisted treatment based on its better bioavailability and efficiency. |
| first_indexed | 2024-04-12T08:30:49Z |
| format | Article |
| id | doaj.art-5abe8c91ca654290b663e27269848a0e |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T08:30:49Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-5abe8c91ca654290b663e27269848a0e2022-12-22T03:40:13ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-07-011410.3389/fnagi.2022.984895984895A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse modelXiwen Geng0Xiwen Geng1Xiwen Geng2Hao Zhang3Hao Zhang4Hao Zhang5Minghui Hu6Minghui Hu7Minghui Hu8Xiaoyu Liu9Min Han10Jinlu Xie11Zifa Li12Zifa Li13Zifa Li14Feng Zhao15Feng Zhao16Feng Zhao17Wei Liu18Sheng Wei19Sheng Wei20Sheng Wei21Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, ChinaKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, ChinaShandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Shandong University of Traditional Chinese Medicine, Jinan, ChinaExperimental Center, Shandong University of Traditional Chinese Medicine, Jinan, ChinaKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, ChinaShandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Shandong University of Traditional Chinese Medicine, Jinan, ChinaExperimental Center, Shandong University of Traditional Chinese Medicine, Jinan, ChinaKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, ChinaShandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Shandong University of Traditional Chinese Medicine, Jinan, ChinaInnovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaKey Laboratory of Vector Biology and Pathogen Control of Zhejiang, School of Medicine, Huzhou Central Hospital, Huzhou University, Huzhou, ChinaExperimental Center, Shandong University of Traditional Chinese Medicine, Jinan, ChinaKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, ChinaShandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Shandong University of Traditional Chinese Medicine, Jinan, ChinaExperimental Center, Shandong University of Traditional Chinese Medicine, Jinan, ChinaKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, ChinaShandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Encephalopathy, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaExperimental Center, Shandong University of Traditional Chinese Medicine, Jinan, ChinaKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, ChinaShandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCurcumin has been reported to improve or prevent movement disorders in Parkinson’s disease (PD); however, its low bioavailability is the biggest obstacle to its application. To optimize the limited efficacy of curcumin and to improve its protective effects against PD, we prepared and tested a novel curcumin oil solution. In vivo imaging was used to confirm that the curcumin oil solution has higher bioavailability than curcumin alone. To test its motor effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced movement disorders, behavioral tests, including the open-field test, pole test, rotarod test, and automated gait analysis were used. Finally, pathological evaluation using immunohistochemistry and western blotting analysis was done. Encouragingly, the behavioral test findings exhibited a better protective effect against MPTP-induced movement disorders. In addition, it had a greater protective effect on dopaminergic neurons in the compact part of the substantia nigra along with the PD process according to pathological evaluation. This novel curcumin oil solution may provide a new choice for PD prevention as a dietary supplement or clinically assisted treatment based on its better bioavailability and efficiency.https://www.frontiersin.org/articles/10.3389/fnagi.2022.984895/fullcurcuminParkinson’s diseaseprotective effectbioavailabilitydopaminergic neuron |
| spellingShingle | Xiwen Geng Xiwen Geng Xiwen Geng Hao Zhang Hao Zhang Hao Zhang Minghui Hu Minghui Hu Minghui Hu Xiaoyu Liu Min Han Jinlu Xie Zifa Li Zifa Li Zifa Li Feng Zhao Feng Zhao Feng Zhao Wei Liu Sheng Wei Sheng Wei Sheng Wei A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model Frontiers in Aging Neuroscience curcumin Parkinson’s disease protective effect bioavailability dopaminergic neuron |
| title | A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model |
| title_full | A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model |
| title_fullStr | A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model |
| title_full_unstemmed | A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model |
| title_short | A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model |
| title_sort | novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a parkinson s disease mouse model |
| topic | curcumin Parkinson’s disease protective effect bioavailability dopaminergic neuron |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.984895/full |
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