Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization
In this work we describe the relationship between surface modification of hexagonally ordered mesoporous silica SBA-15 and loading/release characteristics of nonsteroidal anti-inflammatory drug (NSAID) naproxen. Mesoporous silica (MPS) was modified with 3-aminopropyl, phenyl and cyclohexyl groups by...
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MDPI AG
2020-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/20/4722 |
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| author | Lukáš Žid Vladimír Zeleňák Miroslav Almáši Adriana Zeleňáková Jaroslava Szücsová Jozef Bednarčík Monika Šuleková Alexander Hudák Lucia Váhovská |
| author_facet | Lukáš Žid Vladimír Zeleňák Miroslav Almáši Adriana Zeleňáková Jaroslava Szücsová Jozef Bednarčík Monika Šuleková Alexander Hudák Lucia Váhovská |
| author_sort | Lukáš Žid |
| collection | DOAJ |
| description | In this work we describe the relationship between surface modification of hexagonally ordered mesoporous silica SBA-15 and loading/release characteristics of nonsteroidal anti-inflammatory drug (NSAID) naproxen. Mesoporous silica (MPS) was modified with 3-aminopropyl, phenyl and cyclohexyl groups by grafting method. Naproxen was adsorbed into pores of the prepared MPS from ethanol solution using a solvent evaporation method. The release of the drug was performed in buffer medium at pH 2 and physiological solution at pH 7.4. Parent MPSs as well as naproxen loaded MPSs were characterized using physicochemical techniques such as nitrogen adsorption/desorption, thermogravimetric analysis (TG), Zeta potential analysis, Fourier transform infrared spectroscopy (FT-IR), and elemental analysis. The amount of naproxen released from the MPSs into the medium was determined by high-performance liquid chromatography (HPLC). It was shown that the adsorption and desorption characteristics of naproxen are dependent on the pH of the solution and the surface functionalization of the host. |
| first_indexed | 2024-03-10T15:36:25Z |
| format | Article |
| id | doaj.art-5abee7fd7c8140aa84e5d5480d15cef1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:36:25Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5abee7fd7c8140aa84e5d5480d15cef12023-11-20T17:09:37ZengMDPI AGMolecules1420-30492020-10-012520472210.3390/molecules25204722Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface FunctionalizationLukáš Žid0Vladimír Zeleňák1Miroslav Almáši2Adriana Zeleňáková3Jaroslava Szücsová4Jozef Bednarčík5Monika Šuleková6Alexander Hudák7Lucia Váhovská8Department of Inorganic Chemistry Faculty of Science, P.J. Šafárik University, Moyzesova 11, SK-041 54 Košice, SlovakiaDepartment of Inorganic Chemistry Faculty of Science, P.J. Šafárik University, Moyzesova 11, SK-041 54 Košice, SlovakiaDepartment of Inorganic Chemistry Faculty of Science, P.J. Šafárik University, Moyzesova 11, SK-041 54 Košice, SlovakiaInstitute of Physics, P. J. Šafárik University, Park Angelinum 9, 04001 Košice, SlovakiaInstitute of Physics, P. J. Šafárik University, Park Angelinum 9, 04001 Košice, SlovakiaInstitute of Physics, P. J. Šafárik University, Park Angelinum 9, 04001 Košice, SlovakiaDepartment of Chemistry, Biochemistry and Biophysics, Institute of Pharmaceutical Chemistry, The University of Veterinary Medicine and Pharmacy, 04181 Košice, SlovakiaDepartment of Chemistry, Biochemistry and Biophysics, Institute of Pharmaceutical Chemistry, The University of Veterinary Medicine and Pharmacy, 04181 Košice, SlovakiaDepartment of Chemistry, Biochemistry and Biophysics, Institute of Pharmaceutical Chemistry, The University of Veterinary Medicine and Pharmacy, 04181 Košice, SlovakiaIn this work we describe the relationship between surface modification of hexagonally ordered mesoporous silica SBA-15 and loading/release characteristics of nonsteroidal anti-inflammatory drug (NSAID) naproxen. Mesoporous silica (MPS) was modified with 3-aminopropyl, phenyl and cyclohexyl groups by grafting method. Naproxen was adsorbed into pores of the prepared MPS from ethanol solution using a solvent evaporation method. The release of the drug was performed in buffer medium at pH 2 and physiological solution at pH 7.4. Parent MPSs as well as naproxen loaded MPSs were characterized using physicochemical techniques such as nitrogen adsorption/desorption, thermogravimetric analysis (TG), Zeta potential analysis, Fourier transform infrared spectroscopy (FT-IR), and elemental analysis. The amount of naproxen released from the MPSs into the medium was determined by high-performance liquid chromatography (HPLC). It was shown that the adsorption and desorption characteristics of naproxen are dependent on the pH of the solution and the surface functionalization of the host.https://www.mdpi.com/1420-3049/25/20/4722drug delivery systemnanomaterialsmesoporous silicanaproxenprolonged release |
| spellingShingle | Lukáš Žid Vladimír Zeleňák Miroslav Almáši Adriana Zeleňáková Jaroslava Szücsová Jozef Bednarčík Monika Šuleková Alexander Hudák Lucia Váhovská Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization Molecules drug delivery system nanomaterials mesoporous silica naproxen prolonged release |
| title | Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization |
| title_full | Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization |
| title_fullStr | Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization |
| title_full_unstemmed | Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization |
| title_short | Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization |
| title_sort | mesoporous silica as a drug delivery system for naproxen influence of surface functionalization |
| topic | drug delivery system nanomaterials mesoporous silica naproxen prolonged release |
| url | https://www.mdpi.com/1420-3049/25/20/4722 |
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