Cytotoxic secondary metabolites from mangrove-rhizosphere-associated fungus Emericella sp. strain SWR1718
Chemical exploration of mangrove-rhizosphere-associated fungus Emericella sp. strain SWR1718 (Aspergillaceae) was performed through various chromatographic workup procedures. The achieved results afforded one new natural compound, emericelactone E (1) in addition to known compounds (2–7). The planar...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364720301841 |
| _version_ | 1819051884323799040 |
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| author | Raha Orfali Weaam Ebrahim Shagufta Perveen Najwa Mohammad Majrashi Khulud Alluhayb Sherif S. Ebada |
| author_facet | Raha Orfali Weaam Ebrahim Shagufta Perveen Najwa Mohammad Majrashi Khulud Alluhayb Sherif S. Ebada |
| author_sort | Raha Orfali |
| collection | DOAJ |
| description | Chemical exploration of mangrove-rhizosphere-associated fungus Emericella sp. strain SWR1718 (Aspergillaceae) was performed through various chromatographic workup procedures. The achieved results afforded one new natural compound, emericelactone E (1) in addition to known compounds (2–7). The planar structures of the purified compounds were unambiguously carried out using several spectroscopic methods. Both relative and absolute configurations of compound 1 were carefully determined based on NOESY experiments, coupling constants and comparing its optical rotation with related congeners. Moreover, a plausible biosynthetic pathway of 1 and its related derivatives is reported for the first time in our study. The cytotoxic potential of isolated metabolites was assessed toward three human tumor cell lines where some of them exhibited moderate activities compared to paclitaxel as a standard anticancer. |
| first_indexed | 2024-12-21T12:11:02Z |
| format | Article |
| id | doaj.art-5abfdb705242493bbab01d7d376fef9b |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-12-21T12:11:02Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-5abfdb705242493bbab01d7d376fef9b2022-12-21T19:04:34ZengElsevierJournal of King Saud University: Science1018-36472020-07-0132526562661Cytotoxic secondary metabolites from mangrove-rhizosphere-associated fungus Emericella sp. strain SWR1718Raha Orfali0Weaam Ebrahim1Shagufta Perveen2Najwa Mohammad Majrashi3Khulud Alluhayb4Sherif S. Ebada5Department of Pharmacognosy, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia; Corresponding authors at: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, 61710 Al-Karak, Jordan.Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt; Corresponding authors at: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, 61710 Al-Karak, Jordan.Department of Pharmacognosy, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi ArabiaNational Center for Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11461, Saudi ArabiaNational Center for Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11461, Saudi ArabiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, 61710 Al-Karak, Jordan; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566 Abbassia, Cairo, Egypt; Corresponding authors at: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, 61710 Al-Karak, Jordan.Chemical exploration of mangrove-rhizosphere-associated fungus Emericella sp. strain SWR1718 (Aspergillaceae) was performed through various chromatographic workup procedures. The achieved results afforded one new natural compound, emericelactone E (1) in addition to known compounds (2–7). The planar structures of the purified compounds were unambiguously carried out using several spectroscopic methods. Both relative and absolute configurations of compound 1 were carefully determined based on NOESY experiments, coupling constants and comparing its optical rotation with related congeners. Moreover, a plausible biosynthetic pathway of 1 and its related derivatives is reported for the first time in our study. The cytotoxic potential of isolated metabolites was assessed toward three human tumor cell lines where some of them exhibited moderate activities compared to paclitaxel as a standard anticancer.http://www.sciencedirect.com/science/article/pii/S1018364720301841EmericellaMangroveEmericelactoneCytotoxic activity |
| spellingShingle | Raha Orfali Weaam Ebrahim Shagufta Perveen Najwa Mohammad Majrashi Khulud Alluhayb Sherif S. Ebada Cytotoxic secondary metabolites from mangrove-rhizosphere-associated fungus Emericella sp. strain SWR1718 Journal of King Saud University: Science Emericella Mangrove Emericelactone Cytotoxic activity |
| title | Cytotoxic secondary metabolites from mangrove-rhizosphere-associated fungus Emericella sp. strain SWR1718 |
| title_full | Cytotoxic secondary metabolites from mangrove-rhizosphere-associated fungus Emericella sp. strain SWR1718 |
| title_fullStr | Cytotoxic secondary metabolites from mangrove-rhizosphere-associated fungus Emericella sp. strain SWR1718 |
| title_full_unstemmed | Cytotoxic secondary metabolites from mangrove-rhizosphere-associated fungus Emericella sp. strain SWR1718 |
| title_short | Cytotoxic secondary metabolites from mangrove-rhizosphere-associated fungus Emericella sp. strain SWR1718 |
| title_sort | cytotoxic secondary metabolites from mangrove rhizosphere associated fungus emericella sp strain swr1718 |
| topic | Emericella Mangrove Emericelactone Cytotoxic activity |
| url | http://www.sciencedirect.com/science/article/pii/S1018364720301841 |
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