Evaluation of the Effect of (S)-3,4-Dicarboxyphenylglycine as a Metabotropic Glutamate Receptors Subtype 8 Agonist on Thermal Nociception Following Central Neuropathic Pain

Evaluation of the Effect of (S)-3,4-Dicarboxyphenylglycine as a Metabotropic Glutamate Receptors Subtype 8 Agonist on Thermal Nociception Following Central Neuropathic Pain

Study Design In this study, we decided to change the activity of periaqueductal gray (PAG)'s metabotropic glutamate receptors subtype 8 (mGluR8) by means of its specific agonist, (S)-3,4-dicarboxyphenylglycine (DCPG), and by knock downing it with mGluR8 siRNA. We then evaluated the changes in a...

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Bibliographic Details
Main Authors: Marjan Hosseini, Mohsen Parviz, Alireza P. Shabanzadeh, Elham Zamani
Format: Article
Language:English
Published: Korean Spine Society 2021-04-01
Series:Asian Spine Journal
Subjects:
hyperalgesia
metabotropic glutamate receptor 8
spinal cord injuries
3,4-dicarboxyphenylglycine
periaqueductal gray
neuralgia
Online Access:http://www.asianspinejournal.org/upload/pdf/asj-2019-0367.pdf

Internet

http://www.asianspinejournal.org/upload/pdf/asj-2019-0367.pdf

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