Early onset age increases the risk of musculoskeletal damage in patients with type 2 diabetes
IntroductionIt’s not clear whether there are differences in musculoskeletal damage and body composition among different age groups of type 2 diabetes. Therefore, the purpose of this study is to analyze the difference between early-onset type 2 diabetes (EOT2D) and non-early-onset type 2 diabetes (NO...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-12-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1270674/full |
| _version_ | 1827592593027891200 |
|---|---|
| author | Biao Zheng Biao Zheng Biao Zheng Biao Zheng Biao Zheng Biao Zheng Yongze Zhang Yongze Zhang Yongze Zhang Yongze Zhang Yongze Zhang Yongze Zhang Lingning Huang Lingning Huang Lingning Huang Lingning Huang Lingning Huang Lingning Huang Ximei Shen Ximei Shen Ximei Shen Ximei Shen Ximei Shen Ximei Shen Fengying Zhao Fengying Zhao Fengying Zhao Fengying Zhao Fengying Zhao Fengying Zhao Sunjie Yan Sunjie Yan Sunjie Yan Sunjie Yan Sunjie Yan Sunjie Yan |
| author_facet | Biao Zheng Biao Zheng Biao Zheng Biao Zheng Biao Zheng Biao Zheng Yongze Zhang Yongze Zhang Yongze Zhang Yongze Zhang Yongze Zhang Yongze Zhang Lingning Huang Lingning Huang Lingning Huang Lingning Huang Lingning Huang Lingning Huang Ximei Shen Ximei Shen Ximei Shen Ximei Shen Ximei Shen Ximei Shen Fengying Zhao Fengying Zhao Fengying Zhao Fengying Zhao Fengying Zhao Fengying Zhao Sunjie Yan Sunjie Yan Sunjie Yan Sunjie Yan Sunjie Yan Sunjie Yan |
| author_sort | Biao Zheng |
| collection | DOAJ |
| description | IntroductionIt’s not clear whether there are differences in musculoskeletal damage and body composition among different age groups of type 2 diabetes. Therefore, the purpose of this study is to analyze the difference between early-onset type 2 diabetes (EOT2D) and non-early-onset type 2 diabetes (NOT2D) in musculoskeletal damage.MethodsA total of 964 patients with type 2 diabetes mellitus were selected by 1:1 propensity score matching, including 534 males and 430 females, with an average age of 52 ± 7 years and an average course of 10 ± 8.5 years. Bone mineral density and body composition were measured, and combined with biochemical tests, linear regression and binary logic regression were used to analyze the relationship between EOT2D, NOT2D and musculoskeletal damage. In addition, 414 patients with T2DM were selected according to whether they were hospitalized twice or not, and the median follow-up period was 44 months. COX survival analysis further elucidates the relationship between EOT2D, NOT2D and musculoskeletal damage.ResultsCompared with patients with non-early-onset type 2 diabetes, A/G was negatively correlated with the age of onset, and had statistical significance. EOT2D has a higher risk of sarcopenia, osteoporosis and even musculoskeletal damage. With the prolongation of the course of the disease, the risk of muscle mass and/or bone mineral density decrease in EOT2D increases.ConclusionEOT2D brings a greater risk of sarcopenia and/or osteoporosis, as well as a higher risk of reduced ASM and BMD. In addition, fat distribution may be more central. |
| first_indexed | 2024-03-09T01:57:41Z |
| format | Article |
| id | doaj.art-5ac1dd294f0949eebeb9ee9a688dedc5 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-09T01:57:41Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-5ac1dd294f0949eebeb9ee9a688dedc52023-12-08T12:34:26ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-12-011410.3389/fendo.2023.12706741270674Early onset age increases the risk of musculoskeletal damage in patients with type 2 diabetesBiao Zheng0Biao Zheng1Biao Zheng2Biao Zheng3Biao Zheng4Biao Zheng5Yongze Zhang6Yongze Zhang7Yongze Zhang8Yongze Zhang9Yongze Zhang10Yongze Zhang11Lingning Huang12Lingning Huang13Lingning Huang14Lingning Huang15Lingning Huang16Lingning Huang17Ximei Shen18Ximei Shen19Ximei Shen20Ximei Shen21Ximei Shen22Ximei Shen23Fengying Zhao24Fengying Zhao25Fengying Zhao26Fengying Zhao27Fengying Zhao28Fengying Zhao29Sunjie Yan30Sunjie Yan31Sunjie Yan32Sunjie Yan33Sunjie Yan34Sunjie Yan35Department of Endocrinology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Endocrinology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaClinical Research Center for Metabolic Diseases of Fujian Province, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Glycolipid and Bone Mineral Metabolism, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDiabetes Research Institute of Fujian Province, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaMetabolic Diseases Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Endocrinology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Endocrinology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaClinical Research Center for Metabolic Diseases of Fujian Province, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Glycolipid and Bone Mineral Metabolism, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDiabetes Research Institute of Fujian Province, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaMetabolic Diseases Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Endocrinology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Endocrinology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaClinical Research Center for Metabolic Diseases of Fujian Province, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Glycolipid and Bone Mineral Metabolism, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDiabetes Research Institute of Fujian Province, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaMetabolic Diseases Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Endocrinology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Endocrinology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaClinical Research Center for Metabolic Diseases of Fujian Province, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Glycolipid and Bone Mineral Metabolism, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDiabetes Research Institute of Fujian Province, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaMetabolic Diseases Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Endocrinology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Endocrinology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaClinical Research Center for Metabolic Diseases of Fujian Province, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Glycolipid and Bone Mineral Metabolism, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDiabetes Research Institute of Fujian Province, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaMetabolic Diseases Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Endocrinology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Endocrinology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaClinical Research Center for Metabolic Diseases of Fujian Province, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Glycolipid and Bone Mineral Metabolism, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDiabetes Research Institute of Fujian Province, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaMetabolic Diseases Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaIntroductionIt’s not clear whether there are differences in musculoskeletal damage and body composition among different age groups of type 2 diabetes. Therefore, the purpose of this study is to analyze the difference between early-onset type 2 diabetes (EOT2D) and non-early-onset type 2 diabetes (NOT2D) in musculoskeletal damage.MethodsA total of 964 patients with type 2 diabetes mellitus were selected by 1:1 propensity score matching, including 534 males and 430 females, with an average age of 52 ± 7 years and an average course of 10 ± 8.5 years. Bone mineral density and body composition were measured, and combined with biochemical tests, linear regression and binary logic regression were used to analyze the relationship between EOT2D, NOT2D and musculoskeletal damage. In addition, 414 patients with T2DM were selected according to whether they were hospitalized twice or not, and the median follow-up period was 44 months. COX survival analysis further elucidates the relationship between EOT2D, NOT2D and musculoskeletal damage.ResultsCompared with patients with non-early-onset type 2 diabetes, A/G was negatively correlated with the age of onset, and had statistical significance. EOT2D has a higher risk of sarcopenia, osteoporosis and even musculoskeletal damage. With the prolongation of the course of the disease, the risk of muscle mass and/or bone mineral density decrease in EOT2D increases.ConclusionEOT2D brings a greater risk of sarcopenia and/or osteoporosis, as well as a higher risk of reduced ASM and BMD. In addition, fat distribution may be more central.https://www.frontiersin.org/articles/10.3389/fendo.2023.1270674/fullonset-agediabetesosteoporosissarcopeniamusculoskeletal damage |
| spellingShingle | Biao Zheng Biao Zheng Biao Zheng Biao Zheng Biao Zheng Biao Zheng Yongze Zhang Yongze Zhang Yongze Zhang Yongze Zhang Yongze Zhang Yongze Zhang Lingning Huang Lingning Huang Lingning Huang Lingning Huang Lingning Huang Lingning Huang Ximei Shen Ximei Shen Ximei Shen Ximei Shen Ximei Shen Ximei Shen Fengying Zhao Fengying Zhao Fengying Zhao Fengying Zhao Fengying Zhao Fengying Zhao Sunjie Yan Sunjie Yan Sunjie Yan Sunjie Yan Sunjie Yan Sunjie Yan Early onset age increases the risk of musculoskeletal damage in patients with type 2 diabetes Frontiers in Endocrinology onset-age diabetes osteoporosis sarcopenia musculoskeletal damage |
| title | Early onset age increases the risk of musculoskeletal damage in patients with type 2 diabetes |
| title_full | Early onset age increases the risk of musculoskeletal damage in patients with type 2 diabetes |
| title_fullStr | Early onset age increases the risk of musculoskeletal damage in patients with type 2 diabetes |
| title_full_unstemmed | Early onset age increases the risk of musculoskeletal damage in patients with type 2 diabetes |
| title_short | Early onset age increases the risk of musculoskeletal damage in patients with type 2 diabetes |
| title_sort | early onset age increases the risk of musculoskeletal damage in patients with type 2 diabetes |
| topic | onset-age diabetes osteoporosis sarcopenia musculoskeletal damage |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1270674/full |
| work_keys_str_mv | AT biaozheng earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT biaozheng earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT biaozheng earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT biaozheng earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT biaozheng earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT biaozheng earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT yongzezhang earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT yongzezhang earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT yongzezhang earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT yongzezhang earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT yongzezhang earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT yongzezhang earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT lingninghuang earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT lingninghuang earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT lingninghuang earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT lingninghuang earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT lingninghuang earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT lingninghuang earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT ximeishen earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT ximeishen earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT ximeishen earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT ximeishen earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT ximeishen earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT ximeishen earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT fengyingzhao earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT fengyingzhao earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT fengyingzhao earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT fengyingzhao earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT fengyingzhao earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT fengyingzhao earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT sunjieyan earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT sunjieyan earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT sunjieyan earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT sunjieyan earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT sunjieyan earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes AT sunjieyan earlyonsetageincreasestheriskofmusculoskeletaldamageinpatientswithtype2diabetes |