Prosthetic heart valve thrombosis: Diagnosis and newer thrombolytic regimes
Prosthetic heart valve thrombosis incidence is high in developing countries and contributes to significant late mortality postvalve surgery. Many guidelines advocate surgery as the first line therapy though thrombolysis is often used in many centers. In this article, we review the newer regimens of...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Journal of the Practice of Cardiovascular Sciences |
| Subjects: | |
| Online Access: | http://www.j-pcs.org/article.asp?issn=2395-5414;year=2016;volume=2;issue=1;spage=7;epage=12;aulast=Krishnan |
| _version_ | 1811213952175046656 |
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| author | Shanmugam Krishnan |
| author_facet | Shanmugam Krishnan |
| author_sort | Shanmugam Krishnan |
| collection | DOAJ |
| description | Prosthetic heart valve thrombosis incidence is high in developing countries and contributes to significant late mortality postvalve surgery. Many guidelines advocate surgery as the first line therapy though thrombolysis is often used in many centers. In this article, we review the newer regimens of fibrin-specific thrombolytics. Newer regimens of very low-dose, slow infusion lead to equal efficacy with lower complication in majority of patients. Patients with the New York Heart Association (NYHA) Class I–II who have low thrombus burden should receive thrombolysis with low-dose slow infusion while those with high thrombus burden should be planned for surgery. Patients presenting with NYHA Class IV should be treated with classical dose thrombolysis. |
| first_indexed | 2024-04-12T05:54:49Z |
| format | Article |
| id | doaj.art-5ac51bc7bd6c4ca8bf697ed61359876d |
| institution | Directory Open Access Journal |
| issn | 2395-5414 2454-2830 |
| language | English |
| last_indexed | 2024-04-12T05:54:49Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Practice of Cardiovascular Sciences |
| spelling | doaj.art-5ac51bc7bd6c4ca8bf697ed61359876d2022-12-22T03:45:10ZengWolters Kluwer Medknow PublicationsJournal of the Practice of Cardiovascular Sciences2395-54142454-28302016-01-012171210.4103/2395-5414.182993Prosthetic heart valve thrombosis: Diagnosis and newer thrombolytic regimesShanmugam KrishnanProsthetic heart valve thrombosis incidence is high in developing countries and contributes to significant late mortality postvalve surgery. Many guidelines advocate surgery as the first line therapy though thrombolysis is often used in many centers. In this article, we review the newer regimens of fibrin-specific thrombolytics. Newer regimens of very low-dose, slow infusion lead to equal efficacy with lower complication in majority of patients. Patients with the New York Heart Association (NYHA) Class I–II who have low thrombus burden should receive thrombolysis with low-dose slow infusion while those with high thrombus burden should be planned for surgery. Patients presenting with NYHA Class IV should be treated with classical dose thrombolysis.http://www.j-pcs.org/article.asp?issn=2395-5414;year=2016;volume=2;issue=1;spage=7;epage=12;aulast=KrishnanProsthetic heart valve thrombosisstreptokinasethrombolysistissue plasminogen activator |
| spellingShingle | Shanmugam Krishnan Prosthetic heart valve thrombosis: Diagnosis and newer thrombolytic regimes Journal of the Practice of Cardiovascular Sciences Prosthetic heart valve thrombosis streptokinase thrombolysis tissue plasminogen activator |
| title | Prosthetic heart valve thrombosis: Diagnosis and newer thrombolytic regimes |
| title_full | Prosthetic heart valve thrombosis: Diagnosis and newer thrombolytic regimes |
| title_fullStr | Prosthetic heart valve thrombosis: Diagnosis and newer thrombolytic regimes |
| title_full_unstemmed | Prosthetic heart valve thrombosis: Diagnosis and newer thrombolytic regimes |
| title_short | Prosthetic heart valve thrombosis: Diagnosis and newer thrombolytic regimes |
| title_sort | prosthetic heart valve thrombosis diagnosis and newer thrombolytic regimes |
| topic | Prosthetic heart valve thrombosis streptokinase thrombolysis tissue plasminogen activator |
| url | http://www.j-pcs.org/article.asp?issn=2395-5414;year=2016;volume=2;issue=1;spage=7;epage=12;aulast=Krishnan |
| work_keys_str_mv | AT shanmugamkrishnan prostheticheartvalvethrombosisdiagnosisandnewerthrombolyticregimes |