Role of NF-κB Signaling in the Interplay between Multiple Myeloma and Mesenchymal Stromal Cells
Nuclear factor-κB (NF-κB) transcription factors play a key role in the pathogenesis of multiple myeloma (MM). The survival, proliferation and chemoresistance of malignant plasma cells largely rely on the activation of canonical and noncanonical NF-κB pathways. They are triggered by cancer-associated...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/1823 |
| _version_ | 1797624540755394560 |
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| author | Marco Cippitelli Helena Stabile Andrea Kosta Sara Petillo Lorenzo Lucantonio Angela Gismondi Angela Santoni Cinzia Fionda |
| author_facet | Marco Cippitelli Helena Stabile Andrea Kosta Sara Petillo Lorenzo Lucantonio Angela Gismondi Angela Santoni Cinzia Fionda |
| author_sort | Marco Cippitelli |
| collection | DOAJ |
| description | Nuclear factor-κB (NF-κB) transcription factors play a key role in the pathogenesis of multiple myeloma (MM). The survival, proliferation and chemoresistance of malignant plasma cells largely rely on the activation of canonical and noncanonical NF-κB pathways. They are triggered by cancer-associated mutations or by the autocrine and paracrine production of cytokines and growth factors as well as direct interaction with cellular and noncellular components of bone marrow microenvironment (BM). In this context, NF-κB also significantly affects the activity of noncancerous cells, including mesenchymal stromal cells (MSCs), which have a critical role in disease progression. Indeed, NF-κB transcription factors are involved in inflammatory signaling that alters the functional properties of these cells to support cancer evolution. Moreover, they act as regulators and/or effectors of pathways involved in the interplay between MSCs and MM cells. The aim of this review is to analyze the role of NF-κB in this hematologic cancer, focusing on NF-κB-dependent mechanisms in tumor cells, MSCs and myeloma–mesenchymal stromal cell crosstalk. |
| first_indexed | 2024-03-11T09:43:51Z |
| format | Article |
| id | doaj.art-5ac8a522e7c54e13a15b4821b0f30f6d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:43:51Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5ac8a522e7c54e13a15b4821b0f30f6d2023-11-16T16:48:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243182310.3390/ijms24031823Role of NF-κB Signaling in the Interplay between Multiple Myeloma and Mesenchymal Stromal CellsMarco Cippitelli0Helena Stabile1Andrea Kosta2Sara Petillo3Lorenzo Lucantonio4Angela Gismondi5Angela Santoni6Cinzia Fionda7Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, ItalyNuclear factor-κB (NF-κB) transcription factors play a key role in the pathogenesis of multiple myeloma (MM). The survival, proliferation and chemoresistance of malignant plasma cells largely rely on the activation of canonical and noncanonical NF-κB pathways. They are triggered by cancer-associated mutations or by the autocrine and paracrine production of cytokines and growth factors as well as direct interaction with cellular and noncellular components of bone marrow microenvironment (BM). In this context, NF-κB also significantly affects the activity of noncancerous cells, including mesenchymal stromal cells (MSCs), which have a critical role in disease progression. Indeed, NF-κB transcription factors are involved in inflammatory signaling that alters the functional properties of these cells to support cancer evolution. Moreover, they act as regulators and/or effectors of pathways involved in the interplay between MSCs and MM cells. The aim of this review is to analyze the role of NF-κB in this hematologic cancer, focusing on NF-κB-dependent mechanisms in tumor cells, MSCs and myeloma–mesenchymal stromal cell crosstalk.https://www.mdpi.com/1422-0067/24/3/1823NF-kappa Bmultiple myelomamesenchymal stromal cells |
| spellingShingle | Marco Cippitelli Helena Stabile Andrea Kosta Sara Petillo Lorenzo Lucantonio Angela Gismondi Angela Santoni Cinzia Fionda Role of NF-κB Signaling in the Interplay between Multiple Myeloma and Mesenchymal Stromal Cells International Journal of Molecular Sciences NF-kappa B multiple myeloma mesenchymal stromal cells |
| title | Role of NF-κB Signaling in the Interplay between Multiple Myeloma and Mesenchymal Stromal Cells |
| title_full | Role of NF-κB Signaling in the Interplay between Multiple Myeloma and Mesenchymal Stromal Cells |
| title_fullStr | Role of NF-κB Signaling in the Interplay between Multiple Myeloma and Mesenchymal Stromal Cells |
| title_full_unstemmed | Role of NF-κB Signaling in the Interplay between Multiple Myeloma and Mesenchymal Stromal Cells |
| title_short | Role of NF-κB Signaling in the Interplay between Multiple Myeloma and Mesenchymal Stromal Cells |
| title_sort | role of nf κb signaling in the interplay between multiple myeloma and mesenchymal stromal cells |
| topic | NF-kappa B multiple myeloma mesenchymal stromal cells |
| url | https://www.mdpi.com/1422-0067/24/3/1823 |
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