The association between melasma and iron profile: a case-control study
Background — Melasma is a chronic acquired localized hypermelanosis, causing aesthetic problem for women and impairing their quality of life. Evidence has suggested that hyperpigmentation can occur as a result of iron deficiency anemia and vitamin B12 deficiency. Aim — We aimed to evaluate the seru...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Limited liability company «Science and Innovations» (Saratov)
2020-06-01
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| Series: | Russian Open Medical Journal |
| Subjects: | |
| Online Access: | http://www.romj.org/node/321 |
| _version_ | 1819242796425412608 |
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| author | Azadeh Goodarzi Elham Behrangi Afsaneh Sadeghzadeh-Bazargan Masoumeh Roohaninasab Fatemeh Sadat Hosseini-Baharanchi Mahsa Shemshadi Elham Vafaei |
| author_facet | Azadeh Goodarzi Elham Behrangi Afsaneh Sadeghzadeh-Bazargan Masoumeh Roohaninasab Fatemeh Sadat Hosseini-Baharanchi Mahsa Shemshadi Elham Vafaei |
| author_sort | Azadeh Goodarzi |
| collection | DOAJ |
| description | Background — Melasma is a chronic acquired localized hypermelanosis, causing aesthetic problem for women and impairing their quality of life. Evidence has suggested that hyperpigmentation can occur as a result of iron deficiency anemia and vitamin B12 deficiency.
Aim — We aimed to evaluate the serum parameters of iron profile in melasma patients.
Material and Methods — This case-control study investigated 51 adult non pregnant women with melasma, compared with 51 controls, from patients referred to the Hospital, Tehran, Iran, 2017–2018. Melasma was diagnosed clinically according to the melasma area and severity index (MASI) score was calculated and recorded by the physician. The groups were compared in terms of vitamin B12, folate, serum iron, hemoglobin (Hb), mean corpuscular volume (MCV), total iron binding capacity (TIBC), and ferritin.
Results — The mean and standard deviation of the women’s age was 36.89±8.88 years, significantly higher in the group of patients with melasma. Comparing the serum parameters between the groups indicated no statistically significant difference in terms of mean levels of ferritin, Hb, MCV, iron, vitamin B12, TIBC, and folate. The women in melasma group had a higher frequency in below normal range of ferritin and serum iron compared to the control group. None of the serum parameters were correlated with MASI.
Conclusion — The higher frequency of below normal range of ferritin and serum iron levels in women with melasma compared to the control group showed a possible association between these serum parameters and melasma. |
| first_indexed | 2024-12-23T14:45:30Z |
| format | Article |
| id | doaj.art-5ac9929c34954ef2975f7f1bdfbcf891 |
| institution | Directory Open Access Journal |
| issn | 2304-3415 |
| language | English |
| last_indexed | 2024-12-23T14:45:30Z |
| publishDate | 2020-06-01 |
| publisher | Limited liability company «Science and Innovations» (Saratov) |
| record_format | Article |
| series | Russian Open Medical Journal |
| spelling | doaj.art-5ac9929c34954ef2975f7f1bdfbcf8912022-12-21T17:43:06ZengLimited liability company «Science and Innovations» (Saratov)Russian Open Medical Journal2304-34152020-06-0192e020210.15275/rusomj.2020.0202The association between melasma and iron profile: a case-control studyAzadeh GoodarziElham BehrangiAfsaneh Sadeghzadeh-BazarganMasoumeh RoohaninasabFatemeh Sadat Hosseini-BaharanchiMahsa ShemshadiElham VafaeiBackground — Melasma is a chronic acquired localized hypermelanosis, causing aesthetic problem for women and impairing their quality of life. Evidence has suggested that hyperpigmentation can occur as a result of iron deficiency anemia and vitamin B12 deficiency. Aim — We aimed to evaluate the serum parameters of iron profile in melasma patients. Material and Methods — This case-control study investigated 51 adult non pregnant women with melasma, compared with 51 controls, from patients referred to the Hospital, Tehran, Iran, 2017–2018. Melasma was diagnosed clinically according to the melasma area and severity index (MASI) score was calculated and recorded by the physician. The groups were compared in terms of vitamin B12, folate, serum iron, hemoglobin (Hb), mean corpuscular volume (MCV), total iron binding capacity (TIBC), and ferritin. Results — The mean and standard deviation of the women’s age was 36.89±8.88 years, significantly higher in the group of patients with melasma. Comparing the serum parameters between the groups indicated no statistically significant difference in terms of mean levels of ferritin, Hb, MCV, iron, vitamin B12, TIBC, and folate. The women in melasma group had a higher frequency in below normal range of ferritin and serum iron compared to the control group. None of the serum parameters were correlated with MASI. Conclusion — The higher frequency of below normal range of ferritin and serum iron levels in women with melasma compared to the control group showed a possible association between these serum parameters and melasma.http://www.romj.org/node/321melasmamelanosisferritinsanemiairon-deficiencyfolatevitamin b12 |
| spellingShingle | Azadeh Goodarzi Elham Behrangi Afsaneh Sadeghzadeh-Bazargan Masoumeh Roohaninasab Fatemeh Sadat Hosseini-Baharanchi Mahsa Shemshadi Elham Vafaei The association between melasma and iron profile: a case-control study Russian Open Medical Journal melasma melanosis ferritins anemia iron-deficiency folate vitamin b12 |
| title | The association between melasma and iron profile: a case-control study |
| title_full | The association between melasma and iron profile: a case-control study |
| title_fullStr | The association between melasma and iron profile: a case-control study |
| title_full_unstemmed | The association between melasma and iron profile: a case-control study |
| title_short | The association between melasma and iron profile: a case-control study |
| title_sort | association between melasma and iron profile a case control study |
| topic | melasma melanosis ferritins anemia iron-deficiency folate vitamin b12 |
| url | http://www.romj.org/node/321 |
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