| Summary: | Covid-19 has affected many countries globally. Many countries have started vaccinating populations to curb the spread of COVID-19. The Ministries of Health and not-for-profit organizations in African countries have been responsive towards providing their citizens with evidence related to the COVID-19 vaccine. However, vaccine hesitancy continues to threaten the achievement of the required herd immunity to reduce the burden of the disease for many countries. Therefore, interventions to build COVID-19 vaccine trust among populations are critical. Firstly, the engagement of community stakeholders and social influencers is important to address misconceptions about vaccines and debunk social media misinformation. Secondly, information on the COVID-19 vaccine should be simplified for all groups of the population, to ensure that people are not deprived of access to health information and the opportunity to receive the COVID-19 vaccine. This article aimed to describe COVID-19 vaccine acceptance rates, causes, effects, and strategies for improving COVID-19 vaccine uptake in selected countries in Africa.
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