Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application?
Optogenetic methods enable selective de- and hyperpolarization of cardiomyocytes expressing light-sensitive proteins within the myocardium. By using light, this technology provides very high spatial and temporal precision, which is in clear contrast to electrical stimulation. In addition, cardiomyoc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.00675/full |
| _version_ | 1818925593263079424 |
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| author | Philipp Sasse Maximilian Funken Maximilian Funken Thomas Beiert Tobias Bruegmann Tobias Bruegmann Tobias Bruegmann Tobias Bruegmann |
| author_facet | Philipp Sasse Maximilian Funken Maximilian Funken Thomas Beiert Tobias Bruegmann Tobias Bruegmann Tobias Bruegmann Tobias Bruegmann |
| author_sort | Philipp Sasse |
| collection | DOAJ |
| description | Optogenetic methods enable selective de- and hyperpolarization of cardiomyocytes expressing light-sensitive proteins within the myocardium. By using light, this technology provides very high spatial and temporal precision, which is in clear contrast to electrical stimulation. In addition, cardiomyocyte-specific expression would allow pain-free stimulation. In light of these intrinsic technical advantages, optogenetic methods provide an intriguing opportunity to understand and improve current strategies to terminate cardiac arrhythmia as well as for possible pain-free arrhythmia termination in patients in the future. In this review, we give a concise introduction to optogenetic stimulation of cardiomyocytes and the whole heart and summarize the recent progress on optogenetic defibrillation and cardioversion to terminate cardiac arrhythmia. Toward this aim, we specifically focus on the different mechanisms of optogenetic arrhythmia termination and how these might influence the prerequisites for success. Furthermore, we critically discuss the clinical perspectives and potential patient populations, which might benefit from optogenetic defibrillation devices. |
| first_indexed | 2024-12-20T02:43:41Z |
| format | Article |
| id | doaj.art-5aca2d1800c145cd9f21ddeaa098136d |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T02:43:41Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-5aca2d1800c145cd9f21ddeaa098136d2022-12-21T19:56:15ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-06-011010.3389/fphys.2019.00675455846Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application?Philipp Sasse0Maximilian Funken1Maximilian Funken2Thomas Beiert3Tobias Bruegmann4Tobias Bruegmann5Tobias Bruegmann6Tobias Bruegmann7Institute of Physiology I, Medical Faculty, University of Bonn, Bonn, GermanyInstitute of Physiology I, Medical Faculty, University of Bonn, Bonn, GermanyDepartment of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, GermanyDepartment of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, GermanyInstitute of Physiology I, Medical Faculty, University of Bonn, Bonn, GermanyResearch Training Group 1873, University of Bonn, Bonn, GermanyInstitute of Cardiovascular Physiology, University Medical Center, Georg August University Göttingen, Göttingen, GermanyGerman Center for Cardiovascular Research (DZHK), Partner site Göttingen, Göttingen, GermanyOptogenetic methods enable selective de- and hyperpolarization of cardiomyocytes expressing light-sensitive proteins within the myocardium. By using light, this technology provides very high spatial and temporal precision, which is in clear contrast to electrical stimulation. In addition, cardiomyocyte-specific expression would allow pain-free stimulation. In light of these intrinsic technical advantages, optogenetic methods provide an intriguing opportunity to understand and improve current strategies to terminate cardiac arrhythmia as well as for possible pain-free arrhythmia termination in patients in the future. In this review, we give a concise introduction to optogenetic stimulation of cardiomyocytes and the whole heart and summarize the recent progress on optogenetic defibrillation and cardioversion to terminate cardiac arrhythmia. Toward this aim, we specifically focus on the different mechanisms of optogenetic arrhythmia termination and how these might influence the prerequisites for success. Furthermore, we critically discuss the clinical perspectives and potential patient populations, which might benefit from optogenetic defibrillation devices.https://www.frontiersin.org/article/10.3389/fphys.2019.00675/fulloptogeneticsdefibrillationcardioversionventricular arrhythmiaventricular tachycardiaventricular fibrillation |
| spellingShingle | Philipp Sasse Maximilian Funken Maximilian Funken Thomas Beiert Tobias Bruegmann Tobias Bruegmann Tobias Bruegmann Tobias Bruegmann Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application? Frontiers in Physiology optogenetics defibrillation cardioversion ventricular arrhythmia ventricular tachycardia ventricular fibrillation |
| title | Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application? |
| title_full | Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application? |
| title_fullStr | Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application? |
| title_full_unstemmed | Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application? |
| title_short | Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application? |
| title_sort | optogenetic termination of cardiac arrhythmia mechanistic enlightenment and therapeutic application |
| topic | optogenetics defibrillation cardioversion ventricular arrhythmia ventricular tachycardia ventricular fibrillation |
| url | https://www.frontiersin.org/article/10.3389/fphys.2019.00675/full |
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