The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment

The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment

Lactate is an end product of glycolysis. Owing to the lactate shuttle concept introduced in the early 1980s, increasing researchers indicate lactate as a critical energy source for mitochondrial respiration and as a precursor of gluconeogenesis. Lactate also acts as a multifunctional signaling molec...

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Bibliographic Details
Main Authors: Yan Zhang, Qiu Peng, Jinhua Zheng, Yuzhong Yang, Xuemei Zhang, Aiyu Ma, Yuxia Qin, Zailong Qin, Xiang Zheng
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-09-01
Series:Genes and Diseases
Subjects:
Epigenetic regulation
Lactate
Lactylation
Microenvironment
Tumorigenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304222002690

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