Spontaneous Vertebral Aspergillosis, the State of Art: A Systematic Literature Review
Objective Vertebral aspergillosis is quite rare conditions, often misdiagnosed, that requires long-term antibiotic therapy, and sometimes, surgical treatments. The present investigations were aimed to investigate the epidemiology, clinical-radiological aspects, treatment protocols, and outcomes of A...
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| Format: | Article |
| Language: | English |
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Korean Spinal Neurosurgery Society
2021-03-01
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| Series: | Neurospine |
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| Online Access: | http://www.e-neurospine.org/upload/pdf/ns-2040338-169.pdf |
| _version_ | 1827361848924569600 |
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| author | Andrea Perna Luca Ricciardi Massimo Fantoni Francesco Taccari Riccardo Torelli Domenico Alessandro Santagada Caterina Fumo Francesco Ciro Tamburrelli Luca Proietti |
| author_facet | Andrea Perna Luca Ricciardi Massimo Fantoni Francesco Taccari Riccardo Torelli Domenico Alessandro Santagada Caterina Fumo Francesco Ciro Tamburrelli Luca Proietti |
| author_sort | Andrea Perna |
| collection | DOAJ |
| description | Objective Vertebral aspergillosis is quite rare conditions, often misdiagnosed, that requires long-term antibiotic therapy, and sometimes, surgical treatments. The present investigations were aimed to investigate the epidemiology, clinical-radiological aspects, treatment protocols, and outcomes of Aspergillus-mediated vertebral osteomyelitis. Methods A systematic review of the pertinent English literature according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was performed. The research was conducted on Cochrane library, MEDLINE, PubMed, and Scopus using as search-terms “Aspergillus,” “vertebral osteomyelitis,” “spondylodiscitis,” “spine infection.” A case of vertebral aspergillosis conservatively managed was also reported. Results Eighty-nine articles were included in our systematic review. Including the reported case, our analysis covered 112 cases of vertebral aspergillosis. Aspergillus fumigatus was isolated in 68 cases (61.2%), Aspergillus flavus in 14 (12.6%), Aspergillus terreus in 4 (3.6%), Aspergillus nidulans in 2 (1.8%). Seventy-three patients (65.7%) completely recovered at the last follow-up evaluation; in 7 patients (6.3%) radiological signs of chronic infection were reported, whereas 32 patients (28.8%) died during the follow-up. Conclusion This systematic review summarized the state of the art on vertebral aspergillosis, retrieving data on clinical features, diagnostic criteria and current limitations, treatment alternatives, and their outcomes. |
| first_indexed | 2024-03-08T07:13:26Z |
| format | Article |
| id | doaj.art-5acb790c2f92478c9b48758b0d87c330 |
| institution | Directory Open Access Journal |
| issn | 2586-6583 2586-6591 |
| language | English |
| last_indexed | 2024-03-08T07:13:26Z |
| publishDate | 2021-03-01 |
| publisher | Korean Spinal Neurosurgery Society |
| record_format | Article |
| series | Neurospine |
| spelling | doaj.art-5acb790c2f92478c9b48758b0d87c3302024-02-03T01:54:52ZengKorean Spinal Neurosurgery SocietyNeurospine2586-65832586-65912021-03-01181233310.14245/ns.2040338.1691078Spontaneous Vertebral Aspergillosis, the State of Art: A Systematic Literature ReviewAndrea Perna0Luca Ricciardi1Massimo Fantoni2Francesco Taccari3Riccardo Torelli4Domenico Alessandro Santagada5Caterina Fumo6Francesco Ciro Tamburrelli7Luca Proietti8 UOC Chirurgia Vertebrale, Fondazione Policlinico Universitario Agostino Gemelli – IRCCS, Rome, Italy UO di Neurochirurgia, Pia fondazione di Culto e Religione Cardinal G. Panico, Tricase, Italy Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy Dipartimento di Sicurezza e Bioetica, Università Cattolica S. Cuore, Rome, Italy Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy UOC Chirurgia Vertebrale, Fondazione Policlinico Universitario Agostino Gemelli – IRCCS, Rome, Italy UOC Chirurgia Vertebrale, Fondazione Policlinico Universitario Agostino Gemelli – IRCCS, Rome, Italy UOC Chirurgia Vertebrale, Fondazione Policlinico Universitario Agostino Gemelli – IRCCS, Rome, Italy UOC Chirurgia Vertebrale, Fondazione Policlinico Universitario Agostino Gemelli – IRCCS, Rome, ItalyObjective Vertebral aspergillosis is quite rare conditions, often misdiagnosed, that requires long-term antibiotic therapy, and sometimes, surgical treatments. The present investigations were aimed to investigate the epidemiology, clinical-radiological aspects, treatment protocols, and outcomes of Aspergillus-mediated vertebral osteomyelitis. Methods A systematic review of the pertinent English literature according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was performed. The research was conducted on Cochrane library, MEDLINE, PubMed, and Scopus using as search-terms “Aspergillus,” “vertebral osteomyelitis,” “spondylodiscitis,” “spine infection.” A case of vertebral aspergillosis conservatively managed was also reported. Results Eighty-nine articles were included in our systematic review. Including the reported case, our analysis covered 112 cases of vertebral aspergillosis. Aspergillus fumigatus was isolated in 68 cases (61.2%), Aspergillus flavus in 14 (12.6%), Aspergillus terreus in 4 (3.6%), Aspergillus nidulans in 2 (1.8%). Seventy-three patients (65.7%) completely recovered at the last follow-up evaluation; in 7 patients (6.3%) radiological signs of chronic infection were reported, whereas 32 patients (28.8%) died during the follow-up. Conclusion This systematic review summarized the state of the art on vertebral aspergillosis, retrieving data on clinical features, diagnostic criteria and current limitations, treatment alternatives, and their outcomes.http://www.e-neurospine.org/upload/pdf/ns-2040338-169.pdfaspergillosisdiscitisosteomyelitisspinal osteomyelitis |
| spellingShingle | Andrea Perna Luca Ricciardi Massimo Fantoni Francesco Taccari Riccardo Torelli Domenico Alessandro Santagada Caterina Fumo Francesco Ciro Tamburrelli Luca Proietti Spontaneous Vertebral Aspergillosis, the State of Art: A Systematic Literature Review Neurospine aspergillosis discitis osteomyelitis spinal osteomyelitis |
| title | Spontaneous Vertebral Aspergillosis, the State of Art: A Systematic Literature Review |
| title_full | Spontaneous Vertebral Aspergillosis, the State of Art: A Systematic Literature Review |
| title_fullStr | Spontaneous Vertebral Aspergillosis, the State of Art: A Systematic Literature Review |
| title_full_unstemmed | Spontaneous Vertebral Aspergillosis, the State of Art: A Systematic Literature Review |
| title_short | Spontaneous Vertebral Aspergillosis, the State of Art: A Systematic Literature Review |
| title_sort | spontaneous vertebral aspergillosis the state of art a systematic literature review |
| topic | aspergillosis discitis osteomyelitis spinal osteomyelitis |
| url | http://www.e-neurospine.org/upload/pdf/ns-2040338-169.pdf |
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