Araguspongine C Induces Autophagic Death in Breast Cancer Cells through Suppression of c-Met and HER2 Receptor Tyrosine Kinase Signaling

Araguspongine C Induces Autophagic Death in Breast Cancer Cells through Suppression of c-Met and HER2 Receptor Tyrosine Kinase Signaling

Receptor tyrosine kinases are key regulators of cellular growth and proliferation. Dysregulations of receptor tyrosine kinases in cancer cells may promote tumorigenesis by multiple mechanisms including enhanced cell survival and inhibition of cell death. Araguspongines represent a group of macrocycl...

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Bibliographic Details
Main Authors: Mohamed R. Akl, Nehad M. Ayoub, Hassan Y. Ebrahim, Mohamed M. Mohyeldin, Khaled Y. Orabi, Ahmed I. Foudah, Khalid A. El Sayed
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Marine Drugs
Subjects:
araguspongine C
autophagy
breast cancer
c-Met
HER2
Online Access:http://www.mdpi.com/1660-3397/13/1/288

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