Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes
In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-<i>N</i>-phenyl-1H-pyrazole-3-carboxamide (<b>L<sub>1</sub></b>) and 1,5-dimethyl-<i>N</i>-propyl-1H-pyrazole-3-carboxamide (<b>L<sub...
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| Format: | Article |
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MDPI AG
2024-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/5/1186 |
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| author | Amal El Mahdaoui Smaail Radi Youssef Draoui Mohamed El Massaoudi Sabir Ouahhoud Abdeslam Asehraou Nour Eddine Bentouhami Ennouamane Saalaoui Redouane Benabbes Koen Robeyns Yann Garcia |
| author_facet | Amal El Mahdaoui Smaail Radi Youssef Draoui Mohamed El Massaoudi Sabir Ouahhoud Abdeslam Asehraou Nour Eddine Bentouhami Ennouamane Saalaoui Redouane Benabbes Koen Robeyns Yann Garcia |
| author_sort | Amal El Mahdaoui |
| collection | DOAJ |
| description | In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-<i>N</i>-phenyl-1H-pyrazole-3-carboxamide (<b>L<sub>1</sub></b>) and 1,5-dimethyl-<i>N</i>-propyl-1H-pyrazole-3-carboxamide (<b>L<sub>2</sub></b>), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni(<b>L<sub>1</sub></b>)<sub>2</sub>](ClO<sub>4</sub>)<sub>2</sub> (<b>C<sub>1</sub></b>) and a dinuclear complex [Cd<sub>2</sub>(<b>L<sub>2</sub></b>)<sub>2</sub>]Cl<sub>4</sub> (<b>C<sub>2</sub></b>). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, <b>L<sub>1</sub></b> and <b>L<sub>2</sub></b> present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes <b>C<sub>1</sub></b> and <b>C<sub>2</sub></b>. |
| first_indexed | 2024-04-25T00:23:15Z |
| format | Article |
| id | doaj.art-5acc4d58867f42779cce830f7623d91e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-25T00:23:15Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5acc4d58867f42779cce830f7623d91e2024-03-12T16:51:25ZengMDPI AGMolecules1420-30492024-03-01295118610.3390/molecules29051186Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination ComplexesAmal El Mahdaoui0Smaail Radi1Youssef Draoui2Mohamed El Massaoudi3Sabir Ouahhoud4Abdeslam Asehraou5Nour Eddine Bentouhami6Ennouamane Saalaoui7Redouane Benabbes8Koen Robeyns9Yann Garcia10LCAE, Department of Chemistry, Faculty of Sciences, University Mohammed I, Oujda 60000, MoroccoLCAE, Department of Chemistry, Faculty of Sciences, University Mohammed I, Oujda 60000, MoroccoLCAE, Department of Chemistry, Faculty of Sciences, University Mohammed I, Oujda 60000, MoroccoLCAE, Department of Chemistry, Faculty of Sciences, University Mohammed I, Oujda 60000, MoroccoLaboratory of Bioresource Biotechnology Ethnopharmacology and Health, Faculty of Sciences, University Mohammed I, Oujda 60000, MoroccoLaboratory of Bioresource Biotechnology Ethnopharmacology and Health, Faculty of Sciences, University Mohammed I, Oujda 60000, MoroccoLaboratory of Bioresource Biotechnology Ethnopharmacology and Health, Faculty of Sciences, University Mohammed I, Oujda 60000, MoroccoLaboratory of Bioresource Biotechnology Ethnopharmacology and Health, Faculty of Sciences, University Mohammed I, Oujda 60000, MoroccoLaboratory of Bioresource Biotechnology Ethnopharmacology and Health, Faculty of Sciences, University Mohammed I, Oujda 60000, MoroccoInstitute of Condensed Matter and Nanosciences, Molecular Chemistry, Materials and Catalysis (IMCN/MOST), Université Catholique de Louvain, Place Louis Pasteur 1, 1348 Louvain-la-Neuve, BelgiumInstitute of Condensed Matter and Nanosciences, Molecular Chemistry, Materials and Catalysis (IMCN/MOST), Université Catholique de Louvain, Place Louis Pasteur 1, 1348 Louvain-la-Neuve, BelgiumIn this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-<i>N</i>-phenyl-1H-pyrazole-3-carboxamide (<b>L<sub>1</sub></b>) and 1,5-dimethyl-<i>N</i>-propyl-1H-pyrazole-3-carboxamide (<b>L<sub>2</sub></b>), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni(<b>L<sub>1</sub></b>)<sub>2</sub>](ClO<sub>4</sub>)<sub>2</sub> (<b>C<sub>1</sub></b>) and a dinuclear complex [Cd<sub>2</sub>(<b>L<sub>2</sub></b>)<sub>2</sub>]Cl<sub>4</sub> (<b>C<sub>2</sub></b>). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, <b>L<sub>1</sub></b> and <b>L<sub>2</sub></b> present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes <b>C<sub>1</sub></b> and <b>C<sub>2</sub></b>.https://www.mdpi.com/1420-3049/29/5/1186pyrazoleamidecoordination complexesantibacterial and antifungal activitygenotoxicity |
| spellingShingle | Amal El Mahdaoui Smaail Radi Youssef Draoui Mohamed El Massaoudi Sabir Ouahhoud Abdeslam Asehraou Nour Eddine Bentouhami Ennouamane Saalaoui Redouane Benabbes Koen Robeyns Yann Garcia Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes Molecules pyrazole amide coordination complexes antibacterial and antifungal activity genotoxicity |
| title | Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes |
| title_full | Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes |
| title_fullStr | Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes |
| title_full_unstemmed | Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes |
| title_short | Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes |
| title_sort | synthesis crystal structures genotoxicity and antifungal and antibacterial studies of ni ii and cd ii pyrazole amide coordination complexes |
| topic | pyrazole amide coordination complexes antibacterial and antifungal activity genotoxicity |
| url | https://www.mdpi.com/1420-3049/29/5/1186 |
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