Research progress on the mechanism of annexin A family members in breast cancer
The annexins(ANX) family is widely present in the cell membrane, cytoplasm or extracellular matrix. As key tumor regulatory molecules, annexins A (ANX A) family can promote or inhibit invasion and metastasis of breast cancer cells by influencing cell membrane and cytoskeleton formation and participa...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2024-03-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-3-393.pdf |
| _version_ | 1797294068980514816 |
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| author | NAN Lu, GUO Menjie, GAO Yanan, JIA Hongyan |
| author_facet | NAN Lu, GUO Menjie, GAO Yanan, JIA Hongyan |
| author_sort | NAN Lu, GUO Menjie, GAO Yanan, JIA Hongyan |
| collection | DOAJ |
| description | The annexins(ANX) family is widely present in the cell membrane, cytoplasm or extracellular matrix. As key tumor regulatory molecules, annexins A (ANX A) family can promote or inhibit invasion and metastasis of breast cancer cells by influencing cell membrane and cytoskeleton formation and participating in signaling pathways. ANX A family also plays a role in the apoptosis of breast cancer cells by regulation of pro-apoptotic proteins and cell cycle independent kinases (CDKs) and related pathways. In addition, ANX A family can also promote therapeutic resistance to a large number of drugs. For instance,ANX A1 enhances triple-negative breast cancer resistance by inducing epithelial-mesenchymal transformation. ANX A4 induces resistance by forming ANX A4-Fhit complexes and secretion of exosomes containing ANX A6 promotes paclitaxel resistance in breast cancer cells in a YAP1-dependent manner. So ANX A family may be a new target for breast cancer treatment. |
| first_indexed | 2024-03-07T21:24:48Z |
| format | Article |
| id | doaj.art-5acc887e5f704c4fa2fdf73545f68ddd |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-07T21:24:48Z |
| publishDate | 2024-03-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-5acc887e5f704c4fa2fdf73545f68ddd2024-02-27T06:29:54ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252024-03-0144339339710.16352/j.issn.1001-6325.2024.03.0393Research progress on the mechanism of annexin A family members in breast cancerNAN Lu, GUO Menjie, GAO Yanan, JIA Hongyan01. The First Clinical College of Medicine, Shanxi Medical University, Taiyuan 030001; ;2. Department of Breast, the First Hospital of Shanxi Medical University, Taiyuan 030001, ChinaThe annexins(ANX) family is widely present in the cell membrane, cytoplasm or extracellular matrix. As key tumor regulatory molecules, annexins A (ANX A) family can promote or inhibit invasion and metastasis of breast cancer cells by influencing cell membrane and cytoskeleton formation and participating in signaling pathways. ANX A family also plays a role in the apoptosis of breast cancer cells by regulation of pro-apoptotic proteins and cell cycle independent kinases (CDKs) and related pathways. In addition, ANX A family can also promote therapeutic resistance to a large number of drugs. For instance,ANX A1 enhances triple-negative breast cancer resistance by inducing epithelial-mesenchymal transformation. ANX A4 induces resistance by forming ANX A4-Fhit complexes and secretion of exosomes containing ANX A6 promotes paclitaxel resistance in breast cancer cells in a YAP1-dependent manner. So ANX A family may be a new target for breast cancer treatment.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-3-393.pdfannexins a family|breast cancer|tumorigenesis |
| spellingShingle | NAN Lu, GUO Menjie, GAO Yanan, JIA Hongyan Research progress on the mechanism of annexin A family members in breast cancer Jichu yixue yu linchuang annexins a family|breast cancer|tumorigenesis |
| title | Research progress on the mechanism of annexin A family members in breast cancer |
| title_full | Research progress on the mechanism of annexin A family members in breast cancer |
| title_fullStr | Research progress on the mechanism of annexin A family members in breast cancer |
| title_full_unstemmed | Research progress on the mechanism of annexin A family members in breast cancer |
| title_short | Research progress on the mechanism of annexin A family members in breast cancer |
| title_sort | research progress on the mechanism of annexin a family members in breast cancer |
| topic | annexins a family|breast cancer|tumorigenesis |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-3-393.pdf |
| work_keys_str_mv | AT nanluguomenjiegaoyananjiahongyan researchprogressonthemechanismofannexinafamilymembersinbreastcancer |