Interleukin-35 Attenuates D-Galactosamine/Lipopolysaccharide-Induced Liver Injury via Enhancing Interleukin-10 Production in Kupffer Cells

Interleukin-35 Attenuates D-Galactosamine/Lipopolysaccharide-Induced Liver Injury via Enhancing Interleukin-10 Production in Kupffer Cells

Interleukin (IL) -35 is an anti-inflammatory cytokine which exerts various beneficial effects on autoimmune diseases. However, whether IL-35 plays a role in endotoxin induced hepatitis demands clarification. This study aims to reveal the effect and mechanism of IL-35 on endotoxin induced liver injur...

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Bibliographic Details
Main Authors: Xing-Feng Zheng, Xiao-Yan Hu, Bing Ma, He Fang, Fang Zhang, Yan-Fei Mao, Feng-Yong Yang, Shi-Chu Xiao, Zhao-Fan Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
interleukin-35
hepatitis
lipopolysaccharide
Kupffer cell
interleukin-10
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00959/full

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