Conserved Roles of MonA in Fungal Growth and Development in Aspergillus Species
MonA is a subunit of a guanine nucleotide exchange factor that is important for vacuole passing and autophagy processes in eukaryotes. In this study, we characterized the function of MonA, an orthologue of Saccharomyces cerevisiae Mon1, in the model fungus Aspergillus nidulans and a toxigenic fungus...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-10-01
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| Series: | Mycobiology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/12298093.2019.1677380 |
| _version_ | 1818135312874864640 |
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| author | Ye-Eun Son Hee-Soo Park |
| author_facet | Ye-Eun Son Hee-Soo Park |
| author_sort | Ye-Eun Son |
| collection | DOAJ |
| description | MonA is a subunit of a guanine nucleotide exchange factor that is important for vacuole passing and autophagy processes in eukaryotes. In this study, we characterized the function of MonA, an orthologue of Saccharomyces cerevisiae Mon1, in the model fungus Aspergillus nidulans and a toxigenic fungus A. flavus. In A. nidulans, the absence of AnimonA led to decreased fungal growth, reduced asexual reproduction, and defective cleistothecia production. In addition, AnimonA deletion mutants exhibited decreased spore viability, had reduced trehalose contents in conidia, and were sensitive to thermal stress. In A. flavus, deletion of AflmonA caused decreased fungal growth and defective production of asexual spores and sclerotia structures. Moreover, the absence of monA affected vacuole morphology in both species. Taken together, these results indicate that MonA plays conserved roles in controlling fungal growth, development and vacuole morphology in A. nidulans and A. flavus. |
| first_indexed | 2024-12-11T09:22:31Z |
| format | Article |
| id | doaj.art-5ace462e13174e7d85ded2a51c89f512 |
| institution | Directory Open Access Journal |
| issn | 1229-8093 2092-9323 |
| language | English |
| last_indexed | 2024-12-11T09:22:31Z |
| publishDate | 2019-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Mycobiology |
| spelling | doaj.art-5ace462e13174e7d85ded2a51c89f5122022-12-22T01:13:14ZengTaylor & Francis GroupMycobiology1229-80932092-93232019-10-0147445746510.1080/12298093.2019.16773801677380Conserved Roles of MonA in Fungal Growth and Development in Aspergillus SpeciesYe-Eun Son0Hee-Soo Park1Kyungpook National UniversityKyungpook National UniversityMonA is a subunit of a guanine nucleotide exchange factor that is important for vacuole passing and autophagy processes in eukaryotes. In this study, we characterized the function of MonA, an orthologue of Saccharomyces cerevisiae Mon1, in the model fungus Aspergillus nidulans and a toxigenic fungus A. flavus. In A. nidulans, the absence of AnimonA led to decreased fungal growth, reduced asexual reproduction, and defective cleistothecia production. In addition, AnimonA deletion mutants exhibited decreased spore viability, had reduced trehalose contents in conidia, and were sensitive to thermal stress. In A. flavus, deletion of AflmonA caused decreased fungal growth and defective production of asexual spores and sclerotia structures. Moreover, the absence of monA affected vacuole morphology in both species. Taken together, these results indicate that MonA plays conserved roles in controlling fungal growth, development and vacuole morphology in A. nidulans and A. flavus.http://dx.doi.org/10.1080/12298093.2019.1677380monaasexual developmentaspergillus nidulansaspergillus flavus |
| spellingShingle | Ye-Eun Son Hee-Soo Park Conserved Roles of MonA in Fungal Growth and Development in Aspergillus Species Mycobiology mona asexual development aspergillus nidulans aspergillus flavus |
| title | Conserved Roles of MonA in Fungal Growth and Development in Aspergillus Species |
| title_full | Conserved Roles of MonA in Fungal Growth and Development in Aspergillus Species |
| title_fullStr | Conserved Roles of MonA in Fungal Growth and Development in Aspergillus Species |
| title_full_unstemmed | Conserved Roles of MonA in Fungal Growth and Development in Aspergillus Species |
| title_short | Conserved Roles of MonA in Fungal Growth and Development in Aspergillus Species |
| title_sort | conserved roles of mona in fungal growth and development in aspergillus species |
| topic | mona asexual development aspergillus nidulans aspergillus flavus |
| url | http://dx.doi.org/10.1080/12298093.2019.1677380 |
| work_keys_str_mv | AT yeeunson conservedrolesofmonainfungalgrowthanddevelopmentinaspergillusspecies AT heesoopark conservedrolesofmonainfungalgrowthanddevelopmentinaspergillusspecies |