Functional state of glutathione system in menopausal women of the Buryat ethnic group with insomnia
The aim of the study was to assess the functional state of glutathione system in menopausal women of the Buryat ethnic group with insomnia. Methods. The study involved 94 women aged 45 to 60 years who were divided into perimenopause (n = 44) and postmenopause (n = 50) groups. In each period, a con...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2022-12-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/3841 |
| _version_ | 1797237132083855360 |
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| author | A. S. Lesnaya N. V. Semenova I. M. Madaeva L. I. Kolesnikova |
| author_facet | A. S. Lesnaya N. V. Semenova I. M. Madaeva L. I. Kolesnikova |
| author_sort | A. S. Lesnaya |
| collection | DOAJ |
| description | The aim of the study was to assess the functional state of glutathione system in menopausal women of the Buryat ethnic group with insomnia. Methods. The study involved 94 women aged 45 to 60 years who were divided into perimenopause (n = 44) and postmenopause (n = 50) groups. In each period, a control group and an insomniac group were identified. The reduced (GSH) and oxidized (GSSG) glutathione levels in erythrocyte lysate, the glutathione-S-transferase π concentration and glutathione reductase activity in blood serum were determined. Results. An increase of the GSH level (p < 0.05) and GSH/GSSG ratio (p < 0.05) both in perimenopausal and postmenopausal women with insomnia were found as compared to controls. There were no differences in the glutathione-depends enzymes parameters. Comparative analysis of the main groups showed an increase GSH/GSSG ratio (p < 0.05) in the postmenopausal period compared with perimenopause. Conclusion. The study results demonstrate the glutathione link activation in Buryat menopausal women with insomnia. In this regard, the appointment of glutathione preparations for the correction of free radical homeostasis in these groups of women cannot be recommended. |
| first_indexed | 2024-03-08T12:15:52Z |
| format | Article |
| id | doaj.art-5ace5526712e4e9ebbd5a600bab96660 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:14:53Z |
| publishDate | 2022-12-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-5ace5526712e4e9ebbd5a600bab966602024-03-28T07:49:27ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962022-12-0175-119520210.29413/ABS.2022-7.5-1.212452Functional state of glutathione system in menopausal women of the Buryat ethnic group with insomniaA. S. Lesnaya0N. V. Semenova1I. M. Madaeva2L. I. Kolesnikova3Scientific Сentre for Family Health and Human Reproduction ProblemsScientific Сentre for Family Health and Human Reproduction ProblemsScientific Сentre for Family Health and Human Reproduction ProblemsScientific Сentre for Family Health and Human Reproduction ProblemsThe aim of the study was to assess the functional state of glutathione system in menopausal women of the Buryat ethnic group with insomnia. Methods. The study involved 94 women aged 45 to 60 years who were divided into perimenopause (n = 44) and postmenopause (n = 50) groups. In each period, a control group and an insomniac group were identified. The reduced (GSH) and oxidized (GSSG) glutathione levels in erythrocyte lysate, the glutathione-S-transferase π concentration and glutathione reductase activity in blood serum were determined. Results. An increase of the GSH level (p < 0.05) and GSH/GSSG ratio (p < 0.05) both in perimenopausal and postmenopausal women with insomnia were found as compared to controls. There were no differences in the glutathione-depends enzymes parameters. Comparative analysis of the main groups showed an increase GSH/GSSG ratio (p < 0.05) in the postmenopausal period compared with perimenopause. Conclusion. The study results demonstrate the glutathione link activation in Buryat menopausal women with insomnia. In this regard, the appointment of glutathione preparations for the correction of free radical homeostasis in these groups of women cannot be recommended.https://www.actabiomedica.ru/jour/article/view/3841glutathioneglutathione reductaseglutathione-s-transferaseinsomniamenopauseethnicity |
| spellingShingle | A. S. Lesnaya N. V. Semenova I. M. Madaeva L. I. Kolesnikova Functional state of glutathione system in menopausal women of the Buryat ethnic group with insomnia Acta Biomedica Scientifica glutathione glutathione reductase glutathione-s-transferase insomnia menopause ethnicity |
| title | Functional state of glutathione system in menopausal women of the Buryat ethnic group with insomnia |
| title_full | Functional state of glutathione system in menopausal women of the Buryat ethnic group with insomnia |
| title_fullStr | Functional state of glutathione system in menopausal women of the Buryat ethnic group with insomnia |
| title_full_unstemmed | Functional state of glutathione system in menopausal women of the Buryat ethnic group with insomnia |
| title_short | Functional state of glutathione system in menopausal women of the Buryat ethnic group with insomnia |
| title_sort | functional state of glutathione system in menopausal women of the buryat ethnic group with insomnia |
| topic | glutathione glutathione reductase glutathione-s-transferase insomnia menopause ethnicity |
| url | https://www.actabiomedica.ru/jour/article/view/3841 |
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