Association of acute‐to‐chronic glycemic ratio and outcomes in patients with COVID‐19 and undiagnosed diabetes mellitus: A retrospective nationwide cohort study
Abstract Aims/Introduction To assess the association of undiagnosed diabetes mellitus and its acute‐to‐chronic glycemic ratio with clinical outcome in patients hospitalized with coronavirus disease 2019 (COVID‐19) using a large‐scale nationwide registry in Japan. Materials and Methods Overall, 4,747...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.13979 |
| _version_ | 1827981603546071040 |
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| author | Masaki Uchihara Takehiro Sugiyama Ryotaro Bouchi Nobuaki Matsunaga Yusuke Asai Hiroyuki Gatanaga Mitsuru Ohsugi Norio Ohmagari Hiroshi Kajio Kohjiro Ueki |
| author_facet | Masaki Uchihara Takehiro Sugiyama Ryotaro Bouchi Nobuaki Matsunaga Yusuke Asai Hiroyuki Gatanaga Mitsuru Ohsugi Norio Ohmagari Hiroshi Kajio Kohjiro Ueki |
| author_sort | Masaki Uchihara |
| collection | DOAJ |
| description | Abstract Aims/Introduction To assess the association of undiagnosed diabetes mellitus and its acute‐to‐chronic glycemic ratio with clinical outcome in patients hospitalized with coronavirus disease 2019 (COVID‐19) using a large‐scale nationwide registry in Japan. Materials and Methods Overall, 4,747 patients were included between July 2021 and January 2022. We evaluated blood glucose and glycated hemoglobin levels at admission, and calculated the acute‐to‐chronic glycemic ratio for each non‐diabetes mellitus, undiagnosed diabetes mellitus and pre‐existing diabetes mellitus group. The primary composite outcome comprised in‐hospital mortality, invasive mechanical ventilation, extracorporeal membrane oxygenation support, intensive care unit admission and transfer to a more advanced medical facility. Results Compared with the non‐diabetes mellitus group, the undiagnosed diabetes mellitus group was significantly associated with a worse COVID‐19 outcome (odds ratio 2.18, 95% confidence interval 1.50–3.18). In patients with undiagnosed diabetes mellitus, the 3rd tertile of the acute‐to‐chronic glycemic ratio was linked with a worse COVID‐19 outcome compared with the 1st tertile (odds ratio 3.33, 95% confidence interval 1.43–7.77), whereas glycated hemoglobin levels were not; among patients with pre‐existing diabetes mellitus, glycated hemoglobin levels were linked with a worse outcome. Conclusions Among patients with undiagnosed diabetes mellitus with COVID‐19, the magnitude of elevation of blood glucose from chronic to acute levels is associated with worse outcomes. |
| first_indexed | 2024-04-09T22:11:42Z |
| format | Article |
| id | doaj.art-5acfbeecc0e54cb796fe47d2b7f4d442 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-04-09T22:11:42Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-5acfbeecc0e54cb796fe47d2b7f4d4422023-03-23T10:50:45ZengWileyJournal of Diabetes Investigation2040-11162040-11242023-04-0114462362910.1111/jdi.13979Association of acute‐to‐chronic glycemic ratio and outcomes in patients with COVID‐19 and undiagnosed diabetes mellitus: A retrospective nationwide cohort studyMasaki Uchihara0Takehiro Sugiyama1Ryotaro Bouchi2Nobuaki Matsunaga3Yusuke Asai4Hiroyuki Gatanaga5Mitsuru Ohsugi6Norio Ohmagari7Hiroshi Kajio8Kohjiro Ueki9Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine Toyama, Tokyo JapanDiabetes and Metabolism Information Center Research Institute, National Center for Global Health and Medicine Toyama, Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine Toyama, Tokyo JapanAMR Clinical Reference Center National Center for Global Health and Medicine Tokyo JapanAMR Clinical Reference Center National Center for Global Health and Medicine Tokyo JapanAIDS Clinical Center National Center for Global Health and Medicine Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine Toyama, Tokyo JapanAIDS Clinical Center National Center for Global Health and Medicine Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine Toyama, Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine Toyama, Tokyo JapanAbstract Aims/Introduction To assess the association of undiagnosed diabetes mellitus and its acute‐to‐chronic glycemic ratio with clinical outcome in patients hospitalized with coronavirus disease 2019 (COVID‐19) using a large‐scale nationwide registry in Japan. Materials and Methods Overall, 4,747 patients were included between July 2021 and January 2022. We evaluated blood glucose and glycated hemoglobin levels at admission, and calculated the acute‐to‐chronic glycemic ratio for each non‐diabetes mellitus, undiagnosed diabetes mellitus and pre‐existing diabetes mellitus group. The primary composite outcome comprised in‐hospital mortality, invasive mechanical ventilation, extracorporeal membrane oxygenation support, intensive care unit admission and transfer to a more advanced medical facility. Results Compared with the non‐diabetes mellitus group, the undiagnosed diabetes mellitus group was significantly associated with a worse COVID‐19 outcome (odds ratio 2.18, 95% confidence interval 1.50–3.18). In patients with undiagnosed diabetes mellitus, the 3rd tertile of the acute‐to‐chronic glycemic ratio was linked with a worse COVID‐19 outcome compared with the 1st tertile (odds ratio 3.33, 95% confidence interval 1.43–7.77), whereas glycated hemoglobin levels were not; among patients with pre‐existing diabetes mellitus, glycated hemoglobin levels were linked with a worse outcome. Conclusions Among patients with undiagnosed diabetes mellitus with COVID‐19, the magnitude of elevation of blood glucose from chronic to acute levels is associated with worse outcomes.https://doi.org/10.1111/jdi.13979Acute‐to‐chronic glycemic ratioCOVID‐19Undiagnosed diabetes mellitus |
| spellingShingle | Masaki Uchihara Takehiro Sugiyama Ryotaro Bouchi Nobuaki Matsunaga Yusuke Asai Hiroyuki Gatanaga Mitsuru Ohsugi Norio Ohmagari Hiroshi Kajio Kohjiro Ueki Association of acute‐to‐chronic glycemic ratio and outcomes in patients with COVID‐19 and undiagnosed diabetes mellitus: A retrospective nationwide cohort study Journal of Diabetes Investigation Acute‐to‐chronic glycemic ratio COVID‐19 Undiagnosed diabetes mellitus |
| title | Association of acute‐to‐chronic glycemic ratio and outcomes in patients with COVID‐19 and undiagnosed diabetes mellitus: A retrospective nationwide cohort study |
| title_full | Association of acute‐to‐chronic glycemic ratio and outcomes in patients with COVID‐19 and undiagnosed diabetes mellitus: A retrospective nationwide cohort study |
| title_fullStr | Association of acute‐to‐chronic glycemic ratio and outcomes in patients with COVID‐19 and undiagnosed diabetes mellitus: A retrospective nationwide cohort study |
| title_full_unstemmed | Association of acute‐to‐chronic glycemic ratio and outcomes in patients with COVID‐19 and undiagnosed diabetes mellitus: A retrospective nationwide cohort study |
| title_short | Association of acute‐to‐chronic glycemic ratio and outcomes in patients with COVID‐19 and undiagnosed diabetes mellitus: A retrospective nationwide cohort study |
| title_sort | association of acute to chronic glycemic ratio and outcomes in patients with covid 19 and undiagnosed diabetes mellitus a retrospective nationwide cohort study |
| topic | Acute‐to‐chronic glycemic ratio COVID‐19 Undiagnosed diabetes mellitus |
| url | https://doi.org/10.1111/jdi.13979 |
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