Pneumoproteins are associated with pulmonary function in HIV-infected persons.
<h4>Background</h4>COPD is a common HIV comorbidity, and HIV-infected individuals have a higher incidence and earlier onset of COPD compared to HIV-uninfected individuals. While the pathogenesis of HIV-associated COPD is largely unknown, chronic inflammation may contribute. Four pneumopr...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0223263 |
| _version_ | 1811167174781304832 |
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| author | Diane Jeon Emily G Chang Maggie McGing Marlena Hartman-Filson Mathew Sommers Eula Lewis John R Balmes Daniela Moisi Michael M Lederman Kristine A Madsen Prescott G Woodruff Peter W Hunt Laurence Huang Inflammation, Aging, Microbes and Obstructive Lung Disease (I AM OLD) Study |
| author_facet | Diane Jeon Emily G Chang Maggie McGing Marlena Hartman-Filson Mathew Sommers Eula Lewis John R Balmes Daniela Moisi Michael M Lederman Kristine A Madsen Prescott G Woodruff Peter W Hunt Laurence Huang Inflammation, Aging, Microbes and Obstructive Lung Disease (I AM OLD) Study |
| author_sort | Diane Jeon |
| collection | DOAJ |
| description | <h4>Background</h4>COPD is a common HIV comorbidity, and HIV-infected individuals have a higher incidence and earlier onset of COPD compared to HIV-uninfected individuals. While the pathogenesis of HIV-associated COPD is largely unknown, chronic inflammation may contribute. Four pneumoproteins known to be markers of lung injury and inflammation have been associated with COPD in HIV-uninfected individuals: PARC/CCL-18, SP-D, CC-16, and sRAGE.<h4>Objective</h4>To determine whether these pneumoproteins are also associated with pulmonary function and COPD Assessment Test (CAT) scores in HIV-infected individuals.<h4>Methods</h4>Associations between plasma pneumoprotein levels and pulmonary function were determined in a cross-sectional study of otherwise healthy HIV-infected individuals enrolled between September 2016 and June 2017. Covariates included HIV-associated (antiretroviral therapy, CD4 count, and viral load) and COPD-associated (smoking and BMI) covariates.<h4>Results</h4>Among 65 participants, 78.5% were male, 50.8% had undetectable viral load, and 76.9% were ever-smokers. Mean post-bronchodilator FEV1/FVC was 0.71, and mean DLco%predicted was 61%. Higher PARC/CCL-18 was associated with lower DLco%predicted and higher CAT score. Higher CC-16 was associated with lower DLco%predicted and lower FVC%predicted.<h4>Conclusions</h4>This exploratory analysis is the first to characterize associations between these four pneumoproteins and pulmonary function in an HIV-infected cohort. Our findings suggest the pathogenesis of HIV-associated COPD may differ from that of non-HIV-associated COPD due to HIV-specific inflammatory changes affecting DLco. PARC/CCL-18 is associated with structural and functional pulmonary abnormalities and may be an important COPD biomarker candidate in HIV infection. Our study is a preliminary step toward finding clinically relevant COPD biomarkers in high-risk populations. |
| first_indexed | 2024-04-10T16:04:44Z |
| format | Article |
| id | doaj.art-5ad0b4d2febd4c9babbcb4eca266ebfb |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T16:04:44Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5ad0b4d2febd4c9babbcb4eca266ebfb2023-02-10T05:31:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-011410e022326310.1371/journal.pone.0223263Pneumoproteins are associated with pulmonary function in HIV-infected persons.Diane JeonEmily G ChangMaggie McGingMarlena Hartman-FilsonMathew SommersEula LewisJohn R BalmesDaniela MoisiMichael M LedermanKristine A MadsenPrescott G WoodruffPeter W HuntLaurence HuangInflammation, Aging, Microbes and Obstructive Lung Disease (I AM OLD) Study<h4>Background</h4>COPD is a common HIV comorbidity, and HIV-infected individuals have a higher incidence and earlier onset of COPD compared to HIV-uninfected individuals. While the pathogenesis of HIV-associated COPD is largely unknown, chronic inflammation may contribute. Four pneumoproteins known to be markers of lung injury and inflammation have been associated with COPD in HIV-uninfected individuals: PARC/CCL-18, SP-D, CC-16, and sRAGE.<h4>Objective</h4>To determine whether these pneumoproteins are also associated with pulmonary function and COPD Assessment Test (CAT) scores in HIV-infected individuals.<h4>Methods</h4>Associations between plasma pneumoprotein levels and pulmonary function were determined in a cross-sectional study of otherwise healthy HIV-infected individuals enrolled between September 2016 and June 2017. Covariates included HIV-associated (antiretroviral therapy, CD4 count, and viral load) and COPD-associated (smoking and BMI) covariates.<h4>Results</h4>Among 65 participants, 78.5% were male, 50.8% had undetectable viral load, and 76.9% were ever-smokers. Mean post-bronchodilator FEV1/FVC was 0.71, and mean DLco%predicted was 61%. Higher PARC/CCL-18 was associated with lower DLco%predicted and higher CAT score. Higher CC-16 was associated with lower DLco%predicted and lower FVC%predicted.<h4>Conclusions</h4>This exploratory analysis is the first to characterize associations between these four pneumoproteins and pulmonary function in an HIV-infected cohort. Our findings suggest the pathogenesis of HIV-associated COPD may differ from that of non-HIV-associated COPD due to HIV-specific inflammatory changes affecting DLco. PARC/CCL-18 is associated with structural and functional pulmonary abnormalities and may be an important COPD biomarker candidate in HIV infection. Our study is a preliminary step toward finding clinically relevant COPD biomarkers in high-risk populations.https://doi.org/10.1371/journal.pone.0223263 |
| spellingShingle | Diane Jeon Emily G Chang Maggie McGing Marlena Hartman-Filson Mathew Sommers Eula Lewis John R Balmes Daniela Moisi Michael M Lederman Kristine A Madsen Prescott G Woodruff Peter W Hunt Laurence Huang Inflammation, Aging, Microbes and Obstructive Lung Disease (I AM OLD) Study Pneumoproteins are associated with pulmonary function in HIV-infected persons. PLoS ONE |
| title | Pneumoproteins are associated with pulmonary function in HIV-infected persons. |
| title_full | Pneumoproteins are associated with pulmonary function in HIV-infected persons. |
| title_fullStr | Pneumoproteins are associated with pulmonary function in HIV-infected persons. |
| title_full_unstemmed | Pneumoproteins are associated with pulmonary function in HIV-infected persons. |
| title_short | Pneumoproteins are associated with pulmonary function in HIV-infected persons. |
| title_sort | pneumoproteins are associated with pulmonary function in hiv infected persons |
| url | https://doi.org/10.1371/journal.pone.0223263 |
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