Relatıonship Between Serum Resistin Levels With Obesity and Insulin Resistance in Type 2 Diabetes Patients
Aim:Type 2 diabetes mellitus (DM) characterized by target-tissue resistance to insülin and it is strongly linked to obesity. The adipocytes derived hormone resistin is involved in tip 2 DM, obesity, insülin resistance and iflammation. The aim of this study is to compare serum resistin levels between...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2017-12-01
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| Series: | Namık Kemal Tıp Dergisi |
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http://namikkemalmedj.com/archives/archive-detail/article-preview/relatonship-between-serum-resistin-levels-with-obe/40414
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| _version_ | 1797912642005762048 |
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| author | Ebru Yorulmaz Ertuğ Mürvet Algemi |
| author_facet | Ebru Yorulmaz Ertuğ Mürvet Algemi |
| author_sort | Ebru Yorulmaz Ertuğ |
| collection | DOAJ |
| description | Aim:Type 2 diabetes mellitus (DM) characterized by target-tissue resistance to insülin and it is strongly linked to obesity. The adipocytes derived hormone resistin is involved in tip 2 DM, obesity, insülin resistance and iflammation. The aim of this study is to compare serum resistin levels between in normal glucose tolerance group (NGT), impaired glucose tolerance group (BGT) and Type 2 DM group and investigate correlations with obesity and insulin resistance.Material and Methods:Firstly, we compared serum concentrations of resistin with glucose,insülin,HbA1C, BMI,HOMA and waist-to-hip ratio in subject with NGT(n=25), BGT(n=23) and type 2 DM(n=24).Later, according to the body mass index(BMI) and homeostasis model assesment of insulin resistance(HOMA-IR) score 72 cases were divided into subgroups; nonobese with BMI<25 kg/²(43 cases), the obese with BMI>25kg/²(29 cases), HOMA-IR(+)(23 cases) and HOMA-IR(-)(49 cases). Fasting serum resistin level was measured by ELISA. Insulin resistance was measured by the(HOMA-IR) formula.Results:There was no statistical difference in resistin levels between NGT, BGT and Type 2 DM groups(p>0,05). Compared with non obese group, obese group showed higher serum resistin levels(p<0,01). HOMA score was found significantly higher in the BGT and Type 2 DM groups than NGT group(p<0,01). Between HOMA-IR(-) group and HOMA-IR(+) group no significant difference was observed between in the levels of resistin(p>0,05). A significant negative correlation observed between resistin and blood glucose waist-to-hip ratio (r=0,45,p<0,05) in NGT group, between resistin and fasting blood glucose, systolic blood pressure, age in BGT group (respectively;r=-0,45,p<05;r=-0,59,p<05;r=-0,53,p<0,01;r=0,46;r=0,45,p<0,05).Conclusion:We concluded that resistin may effect glucose metabolism, linked with obesity but indirectly effect insülin resistance and diabetes. |
| first_indexed | 2024-04-10T11:58:56Z |
| format | Article |
| id | doaj.art-5ad0ba2a2df543abb02ea6b5793eac23 |
| institution | Directory Open Access Journal |
| issn | 2587-0262 |
| language | English |
| last_indexed | 2024-04-10T11:58:56Z |
| publishDate | 2017-12-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Namık Kemal Tıp Dergisi |
| spelling | doaj.art-5ad0ba2a2df543abb02ea6b5793eac232023-02-15T16:16:41ZengGalenos YayincilikNamık Kemal Tıp Dergisi2587-02622017-12-015310911713049054Relatıonship Between Serum Resistin Levels With Obesity and Insulin Resistance in Type 2 Diabetes PatientsEbru Yorulmaz Ertuğ0Mürvet Algemi1 Çerkezköy Devlet Hastanesi Biyokimya Bölümü Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi Biyokimya Bölümü Aim:Type 2 diabetes mellitus (DM) characterized by target-tissue resistance to insülin and it is strongly linked to obesity. The adipocytes derived hormone resistin is involved in tip 2 DM, obesity, insülin resistance and iflammation. The aim of this study is to compare serum resistin levels between in normal glucose tolerance group (NGT), impaired glucose tolerance group (BGT) and Type 2 DM group and investigate correlations with obesity and insulin resistance.Material and Methods:Firstly, we compared serum concentrations of resistin with glucose,insülin,HbA1C, BMI,HOMA and waist-to-hip ratio in subject with NGT(n=25), BGT(n=23) and type 2 DM(n=24).Later, according to the body mass index(BMI) and homeostasis model assesment of insulin resistance(HOMA-IR) score 72 cases were divided into subgroups; nonobese with BMI<25 kg/²(43 cases), the obese with BMI>25kg/²(29 cases), HOMA-IR(+)(23 cases) and HOMA-IR(-)(49 cases). Fasting serum resistin level was measured by ELISA. Insulin resistance was measured by the(HOMA-IR) formula.Results:There was no statistical difference in resistin levels between NGT, BGT and Type 2 DM groups(p>0,05). Compared with non obese group, obese group showed higher serum resistin levels(p<0,01). HOMA score was found significantly higher in the BGT and Type 2 DM groups than NGT group(p<0,01). Between HOMA-IR(-) group and HOMA-IR(+) group no significant difference was observed between in the levels of resistin(p>0,05). A significant negative correlation observed between resistin and blood glucose waist-to-hip ratio (r=0,45,p<0,05) in NGT group, between resistin and fasting blood glucose, systolic blood pressure, age in BGT group (respectively;r=-0,45,p<05;r=-0,59,p<05;r=-0,53,p<0,01;r=0,46;r=0,45,p<0,05).Conclusion:We concluded that resistin may effect glucose metabolism, linked with obesity but indirectly effect insülin resistance and diabetes. http://namikkemalmedj.com/archives/archive-detail/article-preview/relatonship-between-serum-resistin-levels-with-obe/40414 diabetes mellitushomaobesityresistin |
| spellingShingle | Ebru Yorulmaz Ertuğ Mürvet Algemi Relatıonship Between Serum Resistin Levels With Obesity and Insulin Resistance in Type 2 Diabetes Patients Namık Kemal Tıp Dergisi diabetes mellitus homa obesity resistin |
| title | Relatıonship Between Serum Resistin Levels With Obesity and Insulin Resistance in Type 2 Diabetes Patients |
| title_full | Relatıonship Between Serum Resistin Levels With Obesity and Insulin Resistance in Type 2 Diabetes Patients |
| title_fullStr | Relatıonship Between Serum Resistin Levels With Obesity and Insulin Resistance in Type 2 Diabetes Patients |
| title_full_unstemmed | Relatıonship Between Serum Resistin Levels With Obesity and Insulin Resistance in Type 2 Diabetes Patients |
| title_short | Relatıonship Between Serum Resistin Levels With Obesity and Insulin Resistance in Type 2 Diabetes Patients |
| title_sort | relationship between serum resistin levels with obesity and insulin resistance in type 2 diabetes patients |
| topic | diabetes mellitus homa obesity resistin |
| url |
http://namikkemalmedj.com/archives/archive-detail/article-preview/relatonship-between-serum-resistin-levels-with-obe/40414
|
| work_keys_str_mv | AT ebruyorulmazertug relatıonshipbetweenserumresistinlevelswithobesityandinsulinresistanceintype2diabetespatients AT murvetalgemi relatıonshipbetweenserumresistinlevelswithobesityandinsulinresistanceintype2diabetespatients |