Contribution of Epigenetic Modifications to the Decline in Transgene Expression from Plasmid DNA in Mouse Liver

Contribution of Epigenetic Modifications to the Decline in Transgene Expression from Plasmid DNA in Mouse Liver

Short-term expression of transgenes is one of the problems frequently associated with non-viral in vivo gene transfer. To obtain experimental evidence for the design of sustainable transgene expression systems, the contribution of epigenetic modifications to the decline in transgene expression needs...

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Bibliographic Details
Main Authors: Lei Zang, Makiya Nishikawa, Mitsuru Ando, Yuki Takahashi, Yoshinobu Takakura
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Pharmaceutics
Subjects:
transgene expression
CpG
DNA methylation
histone deacetylation
hydrodynamic injection
Online Access:http://www.mdpi.com/1999-4923/7/3/199

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