Cumulative trauma load and timing of trauma prior to military deployment differentially influences inhibitory control processing across deployment
Abstract Military personnel experience high trauma load that can change brain circuitry leading to impaired inhibitory control and posttraumatic stress disorder (PTSD). Inhibitory control processing may be particularly vulnerable to developmental and interpersonal trauma. This study examines the dif...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-48505-7 |
| _version_ | 1797398009680494592 |
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| author | Lisa N. Miller David Forbes Alexander C. McFarlane Ellie Lawrence-Wood Julian G. Simmons Kim Felmingham |
| author_facet | Lisa N. Miller David Forbes Alexander C. McFarlane Ellie Lawrence-Wood Julian G. Simmons Kim Felmingham |
| author_sort | Lisa N. Miller |
| collection | DOAJ |
| description | Abstract Military personnel experience high trauma load that can change brain circuitry leading to impaired inhibitory control and posttraumatic stress disorder (PTSD). Inhibitory control processing may be particularly vulnerable to developmental and interpersonal trauma. This study examines the differential role of cumulative pre-deployment trauma and timing of trauma on inhibitory control using the Go/NoGo paradigm in a military population. The Go/NoGo paradigm was administered to 166 predominately male army combat personnel at pre- and post-deployment. Linear mixed models analyze cumulative trauma, trauma onset, and post-deployment PTSD symptoms on NoGo-N2 and NoGo-P3 amplitude and latency across deployment. Here we report, NoGo-N2 amplitude increases and NoGo-P3 amplitude and latency decreases in those with high prior interpersonal trauma across deployment. Increases in NoGo-P3 amplitude following adolescent-onset trauma and NoGo-P3 latency following childhood-onset and adolescent-onset trauma are seen across deployment. Arousal symptoms positively correlated with conflict monitoring. Our findings support the cumulative trauma load and sensitive period of trauma exposure models for inhibitory control processing in a military population. High cumulative interpersonal trauma impacts conflict monitoring and response suppression and increases PTSD symptoms whereas developmental trauma differentially impacts response suppression. This research highlights the need for tailored strategies for strengthening inhibitory control, and that consider timing and type of trauma in military personnel. |
| first_indexed | 2024-03-09T01:19:28Z |
| format | Article |
| id | doaj.art-5ad319b1017947848e261bd939bdecaa |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T01:19:28Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-5ad319b1017947848e261bd939bdecaa2023-12-10T12:15:32ZengNature PortfolioScientific Reports2045-23222023-12-0113111410.1038/s41598-023-48505-7Cumulative trauma load and timing of trauma prior to military deployment differentially influences inhibitory control processing across deploymentLisa N. Miller0David Forbes1Alexander C. McFarlane2Ellie Lawrence-Wood3Julian G. Simmons4Kim Felmingham5Melbourne School of Psychological Science, Trauma Anxiety and Stress Lab, The University of MelbourneDepartment of Psychiatry, The University of MelbourneDiscipline of Psychiatry, Adelaide Medical School, University of AdelaideDepartment of Psychiatry, The University of MelbourneMelbourne School of Psychological Science, Trauma Anxiety and Stress Lab, The University of MelbourneMelbourne School of Psychological Science, Trauma Anxiety and Stress Lab, The University of MelbourneAbstract Military personnel experience high trauma load that can change brain circuitry leading to impaired inhibitory control and posttraumatic stress disorder (PTSD). Inhibitory control processing may be particularly vulnerable to developmental and interpersonal trauma. This study examines the differential role of cumulative pre-deployment trauma and timing of trauma on inhibitory control using the Go/NoGo paradigm in a military population. The Go/NoGo paradigm was administered to 166 predominately male army combat personnel at pre- and post-deployment. Linear mixed models analyze cumulative trauma, trauma onset, and post-deployment PTSD symptoms on NoGo-N2 and NoGo-P3 amplitude and latency across deployment. Here we report, NoGo-N2 amplitude increases and NoGo-P3 amplitude and latency decreases in those with high prior interpersonal trauma across deployment. Increases in NoGo-P3 amplitude following adolescent-onset trauma and NoGo-P3 latency following childhood-onset and adolescent-onset trauma are seen across deployment. Arousal symptoms positively correlated with conflict monitoring. Our findings support the cumulative trauma load and sensitive period of trauma exposure models for inhibitory control processing in a military population. High cumulative interpersonal trauma impacts conflict monitoring and response suppression and increases PTSD symptoms whereas developmental trauma differentially impacts response suppression. This research highlights the need for tailored strategies for strengthening inhibitory control, and that consider timing and type of trauma in military personnel.https://doi.org/10.1038/s41598-023-48505-7 |
| spellingShingle | Lisa N. Miller David Forbes Alexander C. McFarlane Ellie Lawrence-Wood Julian G. Simmons Kim Felmingham Cumulative trauma load and timing of trauma prior to military deployment differentially influences inhibitory control processing across deployment Scientific Reports |
| title | Cumulative trauma load and timing of trauma prior to military deployment differentially influences inhibitory control processing across deployment |
| title_full | Cumulative trauma load and timing of trauma prior to military deployment differentially influences inhibitory control processing across deployment |
| title_fullStr | Cumulative trauma load and timing of trauma prior to military deployment differentially influences inhibitory control processing across deployment |
| title_full_unstemmed | Cumulative trauma load and timing of trauma prior to military deployment differentially influences inhibitory control processing across deployment |
| title_short | Cumulative trauma load and timing of trauma prior to military deployment differentially influences inhibitory control processing across deployment |
| title_sort | cumulative trauma load and timing of trauma prior to military deployment differentially influences inhibitory control processing across deployment |
| url | https://doi.org/10.1038/s41598-023-48505-7 |
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