Characteristics Associated with Bone Loss after Spinal Cord Injury: Implications for Hip Region Vulnerability
Background In individuals with spinal cord injury (SCI), bone loss progresses rapidly to the area below the level of injury, leading to an increased risk of fracture. However, there are limited data regarding SCI-relevant characteristics for bone loss and the degree of bone loss in individuals with...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2023-10-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2023-1795.pdf |
| _version_ | 1797650412465029120 |
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| author | Sora Han Sungjae Shin Onyoo Kim Namki Hong |
| author_facet | Sora Han Sungjae Shin Onyoo Kim Namki Hong |
| author_sort | Sora Han |
| collection | DOAJ |
| description | Background In individuals with spinal cord injury (SCI), bone loss progresses rapidly to the area below the level of injury, leading to an increased risk of fracture. However, there are limited data regarding SCI-relevant characteristics for bone loss and the degree of bone loss in individuals with SCI compared with that in non-SCI community-dwelling adults. Methods Data from men with SCI who underwent dual-energy X-ray absorptiometry at the National Rehabilitation Center (2008 to 2020) between 12 and 36 months after injury were collected and analyzed. Community-dwelling men were matched 1:1 for age, height, and weight as the control group, using data from the Korea National Health and Nutrition Examination Survey (KNHANES, 2008 to 2011). Results A comparison of the SCI and the matched control group revealed significantly lower hip region T-scores in the SCI group, whereas the lumbar spine T-score did not differ between groups. Among the 113 men with SCI, the paraplegia group exhibited significantly higher Z-scores of the hip region than the tetraplegia group. Participants with motor-incomplete SCI showed relatively preserved Z-scores of the hip region compared to those of the lumbar region. Moreover, in participants with SCI, the percentage of skeletal muscle displayed a moderate positive correlation with femoral neck Z-scores. Conclusion Men with SCI exhibited significantly lower bone mineral density of the hip region than community-dwelling men. Paraplegia rather than tetraplegia, and motor incompleteness rather than motor completeness were protective factors in the hip region. Caution for loss of skeletal muscle mass or increased adiposity is also required. |
| first_indexed | 2024-03-11T15:59:48Z |
| format | Article |
| id | doaj.art-5ad72b0d11794376b98f711ba42084db |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-03-11T15:59:48Z |
| publishDate | 2023-10-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-5ad72b0d11794376b98f711ba42084db2023-10-25T07:28:35ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782023-10-0138557858710.3803/EnM.2023.17952422Characteristics Associated with Bone Loss after Spinal Cord Injury: Implications for Hip Region VulnerabilitySora Han0Sungjae Shin1Onyoo Kim2Namki Hong3 Department of Rehabilitation Medicine, National Rehabilitation Center, Yonsei University College of Medicine, Seoul, Korea Division of Endocrinology, Department of Internal Medicine, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea Department of Rehabilitation Medicine, National Rehabilitation Center, Yonsei University College of Medicine, Seoul, Korea Division of Endocrinology, Department of Internal Medicine, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, KoreaBackground In individuals with spinal cord injury (SCI), bone loss progresses rapidly to the area below the level of injury, leading to an increased risk of fracture. However, there are limited data regarding SCI-relevant characteristics for bone loss and the degree of bone loss in individuals with SCI compared with that in non-SCI community-dwelling adults. Methods Data from men with SCI who underwent dual-energy X-ray absorptiometry at the National Rehabilitation Center (2008 to 2020) between 12 and 36 months after injury were collected and analyzed. Community-dwelling men were matched 1:1 for age, height, and weight as the control group, using data from the Korea National Health and Nutrition Examination Survey (KNHANES, 2008 to 2011). Results A comparison of the SCI and the matched control group revealed significantly lower hip region T-scores in the SCI group, whereas the lumbar spine T-score did not differ between groups. Among the 113 men with SCI, the paraplegia group exhibited significantly higher Z-scores of the hip region than the tetraplegia group. Participants with motor-incomplete SCI showed relatively preserved Z-scores of the hip region compared to those of the lumbar region. Moreover, in participants with SCI, the percentage of skeletal muscle displayed a moderate positive correlation with femoral neck Z-scores. Conclusion Men with SCI exhibited significantly lower bone mineral density of the hip region than community-dwelling men. Paraplegia rather than tetraplegia, and motor incompleteness rather than motor completeness were protective factors in the hip region. Caution for loss of skeletal muscle mass or increased adiposity is also required.http://www.e-enm.org/upload/pdf/enm-2023-1795.pdfspinal cord injuriesosteoporosisbone densityabsorptiometry, photonfemur neck |
| spellingShingle | Sora Han Sungjae Shin Onyoo Kim Namki Hong Characteristics Associated with Bone Loss after Spinal Cord Injury: Implications for Hip Region Vulnerability Endocrinology and Metabolism spinal cord injuries osteoporosis bone density absorptiometry, photon femur neck |
| title | Characteristics Associated with Bone Loss after Spinal Cord Injury: Implications for Hip Region Vulnerability |
| title_full | Characteristics Associated with Bone Loss after Spinal Cord Injury: Implications for Hip Region Vulnerability |
| title_fullStr | Characteristics Associated with Bone Loss after Spinal Cord Injury: Implications for Hip Region Vulnerability |
| title_full_unstemmed | Characteristics Associated with Bone Loss after Spinal Cord Injury: Implications for Hip Region Vulnerability |
| title_short | Characteristics Associated with Bone Loss after Spinal Cord Injury: Implications for Hip Region Vulnerability |
| title_sort | characteristics associated with bone loss after spinal cord injury implications for hip region vulnerability |
| topic | spinal cord injuries osteoporosis bone density absorptiometry, photon femur neck |
| url | http://www.e-enm.org/upload/pdf/enm-2023-1795.pdf |
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