Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways

Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways

The intracellular signaling molecule Dishevelled (Dvl) mediates canonical and non-canonical Wnt signaling via its PDZ domain. Different pathways diverge at this point by a mechanism that remains unclear. Here we show that the peptide-binding pocket of the Dvl PDZ domain can be occupied by Dvl's...

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Bibliographic Details
Main Authors: Ho-Jin Lee, De-Li Shi, Jie J Zheng
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Series:eLife
Subjects:
NMR
Dishevelled
Wnt
PDZ
auto-inhibition
Online Access:https://elifesciences.org/articles/08142

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