A review of therapeutic agents for the management of pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is an uncommon, progressive and life threatening disease characterized by a proliferative vasculopathy of the small muscular pulmonary arterioles resulting in elevated pulmonary vascular resistance and eventually right ventricular failure. An increasing understa...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-01-01
|
| Series: | Therapeutic Advances in Respiratory Disease |
| Online Access: | https://doi.org/10.1177/1753465816665289 |
| _version_ | 1818414211332571136 |
|---|---|
| author | Stella S Hahn Mina Makaryus Arunabh Talwar Mangala Narasimhan Gulrukh Zaidi |
| author_facet | Stella S Hahn Mina Makaryus Arunabh Talwar Mangala Narasimhan Gulrukh Zaidi |
| author_sort | Stella S Hahn |
| collection | DOAJ |
| description | Pulmonary arterial hypertension (PAH) is an uncommon, progressive and life threatening disease characterized by a proliferative vasculopathy of the small muscular pulmonary arterioles resulting in elevated pulmonary vascular resistance and eventually right ventricular failure. An increasing understanding of the pathobiology of PAH and its natural history has led to the development of numerous targeted therapies. Despite these advances there is significant progression of disease and the survival rate remains low. This article reviews the agents currently available for the medical management of PAH. |
| first_indexed | 2024-12-14T11:15:29Z |
| format | Article |
| id | doaj.art-5ad90c45a81048ce86e08ae76a3541fa |
| institution | Directory Open Access Journal |
| issn | 1753-4658 1753-4666 |
| language | English |
| last_indexed | 2024-12-14T11:15:29Z |
| publishDate | 2017-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Respiratory Disease |
| spelling | doaj.art-5ad90c45a81048ce86e08ae76a3541fa2022-12-21T23:04:02ZengSAGE PublishingTherapeutic Advances in Respiratory Disease1753-46581753-46662017-01-011110.1177/1753465816665289A review of therapeutic agents for the management of pulmonary arterial hypertensionStella S HahnMina MakaryusArunabh TalwarMangala NarasimhanGulrukh ZaidiPulmonary arterial hypertension (PAH) is an uncommon, progressive and life threatening disease characterized by a proliferative vasculopathy of the small muscular pulmonary arterioles resulting in elevated pulmonary vascular resistance and eventually right ventricular failure. An increasing understanding of the pathobiology of PAH and its natural history has led to the development of numerous targeted therapies. Despite these advances there is significant progression of disease and the survival rate remains low. This article reviews the agents currently available for the medical management of PAH.https://doi.org/10.1177/1753465816665289 |
| spellingShingle | Stella S Hahn Mina Makaryus Arunabh Talwar Mangala Narasimhan Gulrukh Zaidi A review of therapeutic agents for the management of pulmonary arterial hypertension Therapeutic Advances in Respiratory Disease |
| title | A review of therapeutic agents for the management of pulmonary arterial hypertension |
| title_full | A review of therapeutic agents for the management of pulmonary arterial hypertension |
| title_fullStr | A review of therapeutic agents for the management of pulmonary arterial hypertension |
| title_full_unstemmed | A review of therapeutic agents for the management of pulmonary arterial hypertension |
| title_short | A review of therapeutic agents for the management of pulmonary arterial hypertension |
| title_sort | review of therapeutic agents for the management of pulmonary arterial hypertension |
| url | https://doi.org/10.1177/1753465816665289 |
| work_keys_str_mv | AT stellashahn areviewoftherapeuticagentsforthemanagementofpulmonaryarterialhypertension AT minamakaryus areviewoftherapeuticagentsforthemanagementofpulmonaryarterialhypertension AT arunabhtalwar areviewoftherapeuticagentsforthemanagementofpulmonaryarterialhypertension AT mangalanarasimhan areviewoftherapeuticagentsforthemanagementofpulmonaryarterialhypertension AT gulrukhzaidi areviewoftherapeuticagentsforthemanagementofpulmonaryarterialhypertension AT stellashahn reviewoftherapeuticagentsforthemanagementofpulmonaryarterialhypertension AT minamakaryus reviewoftherapeuticagentsforthemanagementofpulmonaryarterialhypertension AT arunabhtalwar reviewoftherapeuticagentsforthemanagementofpulmonaryarterialhypertension AT mangalanarasimhan reviewoftherapeuticagentsforthemanagementofpulmonaryarterialhypertension AT gulrukhzaidi reviewoftherapeuticagentsforthemanagementofpulmonaryarterialhypertension |