The clinical outcome of postoperative radiotherapy using hybrid planning technique in left breast cancer after breast‐conserving surgery
Abstract Background The purpose of this study is to observe the preliminary clinical outcome and acute toxicity of hybrid intensity modulated radiotherapy and volumetric modulated arc therapy planning technique with simultaneous integrated boost (SIB). Methods From November 2015 to December 2018, 14...
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.5358 |
| _version_ | 1797866836605272064 |
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| author | Ting‐Na Wei Hui‐Ling Yeh Jia‐Fu Lin Chih‐Chiang Hung |
| author_facet | Ting‐Na Wei Hui‐Ling Yeh Jia‐Fu Lin Chih‐Chiang Hung |
| author_sort | Ting‐Na Wei |
| collection | DOAJ |
| description | Abstract Background The purpose of this study is to observe the preliminary clinical outcome and acute toxicity of hybrid intensity modulated radiotherapy and volumetric modulated arc therapy planning technique with simultaneous integrated boost (SIB). Methods From November 2015 to December 2018, 149 female patients with left‐side breast cancer who underwent adjuvant radiotherapy with hybrid IMRT and VMAT planning technique with SIB were reviewed retrospectively. The primary endpoint was acute toxicities and the secondary endpoints were local recurrence‐free survival (LRFS), distant metastasis‐freesurvival (DMFS), disease‐free survival (DFS), and overall survival (OS). Results The median age was 52 years old and median follow‐up was 43.4 months. Eighty‐six percent of patients had acute grade 0 to grade1 dermatitis and 14% had grade 2 dermatitis. No acute radiation pneumonitis, esophagitis, or cardiovascular events were recorded during follow‐up. The 3‐year LRFS, DMFS, DFS, and OS rates were 95.1%, 95.1%, 90.3%, and 97.9%, respectively. The subgroup analysis revealed that patients with lymphovascular invasion had more local recurrence rate and worse DFS rate. Patients with advanced N stage had the trend of worse DMFS. Conclusion In conclusion, the hybrid IMRT and VMAT technique is feasible, safe and has less acute radiation related toxicities in SIB postoperative radiotherapy for left‐sided breast cancer. |
| first_indexed | 2024-04-09T23:31:43Z |
| format | Article |
| id | doaj.art-5ada8ff2dd574db3a065c9d4564748d8 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-09T23:31:43Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-5ada8ff2dd574db3a065c9d4564748d82023-03-21T05:20:40ZengWileyCancer Medicine2045-76342023-03-011255364537110.1002/cam4.5358The clinical outcome of postoperative radiotherapy using hybrid planning technique in left breast cancer after breast‐conserving surgeryTing‐Na Wei0Hui‐Ling Yeh1Jia‐Fu Lin2Chih‐Chiang Hung3Department of Radiation Oncology Taichung Veterans General Hospital Taichung TaiwanDepartment of Radiation Oncology Taichung Veterans General Hospital Taichung TaiwanDepartment of Radiation Physics Taichung Veterans General Hospital Taichung TaiwanDepartment of Breast Surgery Taichung Veterans General Hospital Taichung TaiwanAbstract Background The purpose of this study is to observe the preliminary clinical outcome and acute toxicity of hybrid intensity modulated radiotherapy and volumetric modulated arc therapy planning technique with simultaneous integrated boost (SIB). Methods From November 2015 to December 2018, 149 female patients with left‐side breast cancer who underwent adjuvant radiotherapy with hybrid IMRT and VMAT planning technique with SIB were reviewed retrospectively. The primary endpoint was acute toxicities and the secondary endpoints were local recurrence‐free survival (LRFS), distant metastasis‐freesurvival (DMFS), disease‐free survival (DFS), and overall survival (OS). Results The median age was 52 years old and median follow‐up was 43.4 months. Eighty‐six percent of patients had acute grade 0 to grade1 dermatitis and 14% had grade 2 dermatitis. No acute radiation pneumonitis, esophagitis, or cardiovascular events were recorded during follow‐up. The 3‐year LRFS, DMFS, DFS, and OS rates were 95.1%, 95.1%, 90.3%, and 97.9%, respectively. The subgroup analysis revealed that patients with lymphovascular invasion had more local recurrence rate and worse DFS rate. Patients with advanced N stage had the trend of worse DMFS. Conclusion In conclusion, the hybrid IMRT and VMAT technique is feasible, safe and has less acute radiation related toxicities in SIB postoperative radiotherapy for left‐sided breast cancer.https://doi.org/10.1002/cam4.5358breast cancerprognosisradiotherapysurvival |
| spellingShingle | Ting‐Na Wei Hui‐Ling Yeh Jia‐Fu Lin Chih‐Chiang Hung The clinical outcome of postoperative radiotherapy using hybrid planning technique in left breast cancer after breast‐conserving surgery Cancer Medicine breast cancer prognosis radiotherapy survival |
| title | The clinical outcome of postoperative radiotherapy using hybrid planning technique in left breast cancer after breast‐conserving surgery |
| title_full | The clinical outcome of postoperative radiotherapy using hybrid planning technique in left breast cancer after breast‐conserving surgery |
| title_fullStr | The clinical outcome of postoperative radiotherapy using hybrid planning technique in left breast cancer after breast‐conserving surgery |
| title_full_unstemmed | The clinical outcome of postoperative radiotherapy using hybrid planning technique in left breast cancer after breast‐conserving surgery |
| title_short | The clinical outcome of postoperative radiotherapy using hybrid planning technique in left breast cancer after breast‐conserving surgery |
| title_sort | clinical outcome of postoperative radiotherapy using hybrid planning technique in left breast cancer after breast conserving surgery |
| topic | breast cancer prognosis radiotherapy survival |
| url | https://doi.org/10.1002/cam4.5358 |
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