Neural stem cell regulation, fibroblast growth factors, and the developmental origins of neuropsychiatric disorders
There is increasing appreciation for the neurodevelopmental underpinnings of many psychiatric disorders. Disorders that begin in childhood such as autism, language disorders or mental retardation as well as adult-onset mental disorders may have origins early in neurodevelopment. Neural stem cells (N...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2010-09-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2010.00059/full |
| _version_ | 1819170667455578112 |
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| author | Hanna E Stevens Karen M Smith Brian Rash Flora M Vaccarino |
| author_facet | Hanna E Stevens Karen M Smith Brian Rash Flora M Vaccarino |
| author_sort | Hanna E Stevens |
| collection | DOAJ |
| description | There is increasing appreciation for the neurodevelopmental underpinnings of many psychiatric disorders. Disorders that begin in childhood such as autism, language disorders or mental retardation as well as adult-onset mental disorders may have origins early in neurodevelopment. Neural stem cells (NSCs) can be defined as self-renewing, multipotent cells that are present in both the embryonic and adult brain. Several recent research findings demonstrate that psychiatric illness may begin with abnormal specification, growth, expansion and differentiation of embryonic NSCs. For example, candidate susceptibility genes for schizophrenia, autism and major depression include the signaling molecule Disrupted In Schizophrenia-1 (DISC-1), the homeodomain gene engrailed-2 (EN-2), and several receptor tyrosine kinases (RTKs), including MET, brain-derived growth factor (BDNF) and fibroblast growth factors (FGF), all of which have been shown to play important roles in NSCs or neuronal precursors. We will discuss here stem cell biology, signaling factors that affect these cells, and the potential contribution of these processes to the etiology of neuropsychiatric disorders. Hypotheses about how some of these factors relate to psychiatric disorders will be reviewed. |
| first_indexed | 2024-12-22T19:39:02Z |
| format | Article |
| id | doaj.art-5adb10c9fc5043849ac160d881777448 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-22T19:39:02Z |
| publishDate | 2010-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-5adb10c9fc5043849ac160d8817774482022-12-21T18:14:55ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2010-09-01410.3389/fnins.2010.000591621Neural stem cell regulation, fibroblast growth factors, and the developmental origins of neuropsychiatric disordersHanna E Stevens0Karen M Smith1Brian Rash2Flora M Vaccarino3Yale University School of MedicineYale University School of MedicineYale University School of MedicineYale University School of MedicineThere is increasing appreciation for the neurodevelopmental underpinnings of many psychiatric disorders. Disorders that begin in childhood such as autism, language disorders or mental retardation as well as adult-onset mental disorders may have origins early in neurodevelopment. Neural stem cells (NSCs) can be defined as self-renewing, multipotent cells that are present in both the embryonic and adult brain. Several recent research findings demonstrate that psychiatric illness may begin with abnormal specification, growth, expansion and differentiation of embryonic NSCs. For example, candidate susceptibility genes for schizophrenia, autism and major depression include the signaling molecule Disrupted In Schizophrenia-1 (DISC-1), the homeodomain gene engrailed-2 (EN-2), and several receptor tyrosine kinases (RTKs), including MET, brain-derived growth factor (BDNF) and fibroblast growth factors (FGF), all of which have been shown to play important roles in NSCs or neuronal precursors. We will discuss here stem cell biology, signaling factors that affect these cells, and the potential contribution of these processes to the etiology of neuropsychiatric disorders. Hypotheses about how some of these factors relate to psychiatric disorders will be reviewed.http://journal.frontiersin.org/Journal/10.3389/fnins.2010.00059/fullDepressionNeural Stem CellsSchizophreniaautismfibroblast growth factorinducible pluriopotent stem cells |
| spellingShingle | Hanna E Stevens Karen M Smith Brian Rash Flora M Vaccarino Neural stem cell regulation, fibroblast growth factors, and the developmental origins of neuropsychiatric disorders Frontiers in Neuroscience Depression Neural Stem Cells Schizophrenia autism fibroblast growth factor inducible pluriopotent stem cells |
| title | Neural stem cell regulation, fibroblast growth factors, and the developmental origins of neuropsychiatric disorders |
| title_full | Neural stem cell regulation, fibroblast growth factors, and the developmental origins of neuropsychiatric disorders |
| title_fullStr | Neural stem cell regulation, fibroblast growth factors, and the developmental origins of neuropsychiatric disorders |
| title_full_unstemmed | Neural stem cell regulation, fibroblast growth factors, and the developmental origins of neuropsychiatric disorders |
| title_short | Neural stem cell regulation, fibroblast growth factors, and the developmental origins of neuropsychiatric disorders |
| title_sort | neural stem cell regulation fibroblast growth factors and the developmental origins of neuropsychiatric disorders |
| topic | Depression Neural Stem Cells Schizophrenia autism fibroblast growth factor inducible pluriopotent stem cells |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2010.00059/full |
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