A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines
Several countries have made unremitting efforts to develop an optimal vaccine in the fight against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the increasing occurrence of SARS-CoV-2 variants, current vaccines show decreased neutra...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/14/2/387 |
| _version_ | 1827652150211117056 |
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| author | Naru Zhang Kangchen Li Zezhong Liu Kutty Selva Nandakumar Shibo Jiang |
| author_facet | Naru Zhang Kangchen Li Zezhong Liu Kutty Selva Nandakumar Shibo Jiang |
| author_sort | Naru Zhang |
| collection | DOAJ |
| description | Several countries have made unremitting efforts to develop an optimal vaccine in the fight against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the increasing occurrence of SARS-CoV-2 variants, current vaccines show decreased neutralizing activities, especially towards the Omicron variant. In this context, adding appropriate adjuvants to COVID-19 vaccines can substantially reduce the number of required doses and improve efficacy or cross-neutralizing protection. We mainly focus on research progress and achievements associated with adjuvanted COVID-19 subunit and inactivated vaccines. We further compare the advantages and disadvantages of different adjuvant formulations in order to provide a scientific reference for designing an effective strategy for future vaccine development. |
| first_indexed | 2024-03-09T20:51:31Z |
| format | Article |
| id | doaj.art-5adce6ef8a444376b03996d4664e8cb3 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T20:51:31Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-5adce6ef8a444376b03996d4664e8cb32023-11-23T22:32:04ZengMDPI AGViruses1999-49152022-02-0114238710.3390/v14020387A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 VaccinesNaru Zhang0Kangchen Li1Zezhong Liu2Kutty Selva Nandakumar3Shibo Jiang4Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, ChinaDepartment of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, SwedenKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, ChinaSeveral countries have made unremitting efforts to develop an optimal vaccine in the fight against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the increasing occurrence of SARS-CoV-2 variants, current vaccines show decreased neutralizing activities, especially towards the Omicron variant. In this context, adding appropriate adjuvants to COVID-19 vaccines can substantially reduce the number of required doses and improve efficacy or cross-neutralizing protection. We mainly focus on research progress and achievements associated with adjuvanted COVID-19 subunit and inactivated vaccines. We further compare the advantages and disadvantages of different adjuvant formulations in order to provide a scientific reference for designing an effective strategy for future vaccine development.https://www.mdpi.com/1999-4915/14/2/387COVID-19SARS-CoV-2variantsvaccineadjuvant |
| spellingShingle | Naru Zhang Kangchen Li Zezhong Liu Kutty Selva Nandakumar Shibo Jiang A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines Viruses COVID-19 SARS-CoV-2 variants vaccine adjuvant |
| title | A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines |
| title_full | A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines |
| title_fullStr | A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines |
| title_full_unstemmed | A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines |
| title_short | A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines |
| title_sort | perspective on the roles of adjuvants in developing highly potent covid 19 vaccines |
| topic | COVID-19 SARS-CoV-2 variants vaccine adjuvant |
| url | https://www.mdpi.com/1999-4915/14/2/387 |
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