Hypocretin (Orexin) Replacement Therapies
Twenty-two years after their discovery, the hypocretins (Hcrts), also known as orexins, are two of the most studied peptidergic systems, involved in myriad physiological systems that range from sleep, arousal, motivation, homeostatic regulation, fear, anxiety and learning. A causal relationship betw...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Medicine in Drug Discovery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590098620300579 |
| _version_ | 1818871044230873088 |
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| author | Erica Seigneur Luis de Lecea |
| author_facet | Erica Seigneur Luis de Lecea |
| author_sort | Erica Seigneur |
| collection | DOAJ |
| description | Twenty-two years after their discovery, the hypocretins (Hcrts), also known as orexins, are two of the most studied peptidergic systems, involved in myriad physiological systems that range from sleep, arousal, motivation, homeostatic regulation, fear, anxiety and learning. A causal relationship between activity of Hcrt and arousal stability was established shortly after their discovery and have led to the development of a new class of drugs to treat insomnia. In this review we discuss the many faces of the Hcrt system and examine recent findings that implicate decreased Hcrt function in the pathogenesis of a number of neuropsychiatric conditions. We also discuss future therapeutic strategies to replace or enhance Hcrt function as a treatment option for these neuropsychiatric conditions. |
| first_indexed | 2024-12-19T12:16:39Z |
| format | Article |
| id | doaj.art-5add1d9b5d4543a09b44c9dc68c9fd5a |
| institution | Directory Open Access Journal |
| issn | 2590-0986 |
| language | English |
| last_indexed | 2024-12-19T12:16:39Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Drug Discovery |
| spelling | doaj.art-5add1d9b5d4543a09b44c9dc68c9fd5a2022-12-21T20:21:57ZengElsevierMedicine in Drug Discovery2590-09862020-12-018100070Hypocretin (Orexin) Replacement TherapiesErica Seigneur0Luis de Lecea1Corresponding author at: 1201 Welch Rd, Stanford, CA 94305.; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CACorresponding author at: 1201 Welch Rd, Stanford, CA 94305.; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CATwenty-two years after their discovery, the hypocretins (Hcrts), also known as orexins, are two of the most studied peptidergic systems, involved in myriad physiological systems that range from sleep, arousal, motivation, homeostatic regulation, fear, anxiety and learning. A causal relationship between activity of Hcrt and arousal stability was established shortly after their discovery and have led to the development of a new class of drugs to treat insomnia. In this review we discuss the many faces of the Hcrt system and examine recent findings that implicate decreased Hcrt function in the pathogenesis of a number of neuropsychiatric conditions. We also discuss future therapeutic strategies to replace or enhance Hcrt function as a treatment option for these neuropsychiatric conditions.http://www.sciencedirect.com/science/article/pii/S2590098620300579SleepArousalOrexinNarcolepsyInsomniaHomeostasis |
| spellingShingle | Erica Seigneur Luis de Lecea Hypocretin (Orexin) Replacement Therapies Medicine in Drug Discovery Sleep Arousal Orexin Narcolepsy Insomnia Homeostasis |
| title | Hypocretin (Orexin) Replacement Therapies |
| title_full | Hypocretin (Orexin) Replacement Therapies |
| title_fullStr | Hypocretin (Orexin) Replacement Therapies |
| title_full_unstemmed | Hypocretin (Orexin) Replacement Therapies |
| title_short | Hypocretin (Orexin) Replacement Therapies |
| title_sort | hypocretin orexin replacement therapies |
| topic | Sleep Arousal Orexin Narcolepsy Insomnia Homeostasis |
| url | http://www.sciencedirect.com/science/article/pii/S2590098620300579 |
| work_keys_str_mv | AT ericaseigneur hypocretinorexinreplacementtherapies AT luisdelecea hypocretinorexinreplacementtherapies |